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NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

More than 60 percent of investigational drugs fail in human clinical trials due to a lack of effectiveness, despite promising pre-clinical studies using cell and animal research models.

13 Sep 2017

VUMC and Bayer agree on strategic research alliance to develop new therapies for kidney diseases

Vanderbilt University Medical Center and Bayer have agreed on a five-year strategic research alliance to evaluate new drug candidates for the treatment of kidney diseases, with the goal of accelerating the translation of innovative approaches from the laboratory to pre-clinical development.

12 Sep 2017

TSRI scientists confirm that quality control steps exist to protect production of proteins

The devil, as always, is in the details. The production of proteins is a complex process, made up of a series of smaller intricate biochemical steps that succeeds because of an equally complex number of quality controls. Without them, the process would irreparably break down and diseases like cancer would run rampant.

11 Sep 2017

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Firstly, it is necessary to make a distinction between systemic inflammation and Systemic Inflammatory Response Syndrome (SIRS). SIRS consists of changes in clinical signs including an abnormal body temperature, increased heart rate, increased respiratory rate, an abnormal white cell count (either decreased or elevated), or an increase in band neutrophils.

7 Sep 2017

Natural compound produced by honeybees could become basis for new antibiotics

An antimicrobial compound made by honeybees could become the basis for new antibiotics, according to new research at the University of Illinois at Chicago.

7 Sep 2017

New DNA sequencing technology measures effects of thousands of sequences on gene activity

When a gene is switched on, various stretches of DNA nearby act as 'control dials', influencing the level of activity and the amount of gene product that is made.

7 Sep 2017

Study finds underutilization of lifesaving implantable cardioverter defibrillators in eligible patients

Fewer than 10% of people who experience sudden cardiac arrest (SCA) outside of a hospital survive. Reoccurrence rates after an initial event are high, which is why current Canadian Cardiovascular Society, as well as other international guidelines, strongly recommend the use of implantable cardioverter defibrillators (ICDs) in selected patients who survive cardiac arrest.

7 Sep 2017

Protein that regulates expression of many genes increases lifespan of baker's yeast

To understand and control aging is the aspiration of many scientists. Researchers at the Biozentrum of the University of Basel have now discovered that the protein Gcn4 decreases protein synthesis and extends the life of yeast cells.

6 Sep 2017

Scientists win new funding to speed up translation of MS research into practice

An innovative multiple sclerosis Research Fellowship designed to fast-track scientific knowledge into clinical practice has been awarded to two researchers at the University of Tasmania’s Menzies Institute for Medical Research.

6 Sep 2017

Study explores periodontal status of patients with Chédiak-Higashi syndrome

The International and American Associations for Dental Research have published an article titled "Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response" in the JDR Clinical & Translational Research.

31 Aug 2017

Aridhia signs pioneering research and innovation platform deal with Great Ormond Street Hospital

Aridhia, the cloud-based data analysis platform provider, has agreed a new ten-year deal with Great Ormond Street Hospital NHS Foundation Trust which will see it deliver the research and innovation component of the Trust’s multi-year digital transformation program.

31 Aug 2017

SBP scientist receives DoD award to identify new and efficacious treatments for pancreatic cancer

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that the Department of Defense (DoD) has awarded Cosimo Commisso, Ph.D., a Career Development Award to identify new and efficacious treatments for pancreatic cancer.

29 Aug 2017

Medical care in California's NICUs influenced by infants' racial and ethnic identities

Infants' racial and ethnic identities influence the quality of medical care they receive in California's neonatal intensive care units, a study from the Stanford University School of Medicine has found.

28 Aug 2017

LSU Health New Orleans receives $10 million grant to support research on virus-induced cancers

The National Institute of General Medical Sciences has awarded LSU Health New Orleans a $10 million grant over five years to support new basic research studies advancing the development new diagnostic and therapeutic approaches for virus-induced cancers.

26 Aug 2017

Enhanced levels of NPs in adipose tissue protect against obesity and insulin resistance

Researchers at Sanford Burnham Prebys Medical Discovery Institute in Lake Nona, Florida have shown that enhanced natriuretic peptide (NP) signaling in adipose tissue protects against obesity and insulin resistance.

26 Aug 2017

Researchers develop proof-of-concept nanosystem to enhance visualization of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute have developed a proof-of-concept nanosystem that dramatically improves the visualization of tumors.

24 Aug 2017

New blood test can predict drug resistance in patients with advanced prostate cancer

When bacteria develop antibiotic resistance, treatment with these medications becomes ineffective. Similarly, tumor cells can also change in such a way that renders them resistant to particular medications.

22 Aug 2017

Id genes found to play crucial role in heart development

Researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a crucial role in heart development, telling undifferentiated stem cells to form heart tubes and eventually muscle.

22 Aug 2017

Study provides evidence that oral immunotherapy may be possible cure for peanut allergy

Allergy immunotherapy company Prota Therapeutics Pty Ltd is pleased to announce results from a follow up study of the probiotic and peanut immunotherapy (PPOIT) treatment which it has licensed from the Murdoch Childrens Research Institute, demonstrating long-lasting tolerance effects of treatment more than four years after the original study ended.

18 Aug 2017

Kids First Data Resource Center aims to identify links between birth defects and childhood cancers

Children with structural birth defects are at a much higher risk of developing certain types of childhood cancers but scientists currently lack vital information about why this occurs.

17 Aug 2017

Translation News and Research

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

VUMC and Bayer agree on strategic research alliance to develop new therapies for kidney diseases

TSRI scientists confirm that quality control steps exist to protect production of proteins

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Natural compound produced by honeybees could become basis for new antibiotics

New DNA sequencing technology measures effects of thousands of sequences on gene activity

Study finds underutilization of lifesaving implantable cardioverter defibrillators in eligible patients

Protein that regulates expression of many genes increases lifespan of baker's yeast

Scientists win new funding to speed up translation of MS research into practice

Study explores periodontal status of patients with Chédiak-Higashi syndrome

Aridhia signs pioneering research and innovation platform deal with Great Ormond Street Hospital

SBP scientist receives DoD award to identify new and efficacious treatments for pancreatic cancer

Medical care in California's NICUs influenced by infants' racial and ethnic identities

LSU Health New Orleans receives $10 million grant to support research on virus-induced cancers

Enhanced levels of NPs in adipose tissue protect against obesity and insulin resistance

Researchers develop proof-of-concept nanosystem to enhance visualization of tumors

New blood test can predict drug resistance in patients with advanced prostate cancer

Id genes found to play crucial role in heart development

Study provides evidence that oral immunotherapy may be possible cure for peanut allergy

Kids First Data Resource Center aims to identify links between birth defects and childhood cancers

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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