Tumor Necrosis Factor News and Research

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Discovery sheds light on TNFα protein's role in impairing memory in Alzheimer's disease

Otago scientists have made an important discovery in understanding the role a particular protein plays to impair memory in Alzheimer's disease, which could lead to more effective treatment in future.

23 Oct 2019

Study identifies genetic marker which could personalize treatment for Crohn's disease

The largest study ever to look at why an expensive and commonly used group of drugs fails some patients with Crohn's disease has identified a genetic marker which could individualize drug treatment.

7 Oct 2019

Common genetic variant explains why immunotherapy often fails in Crohn's disease

The reason why a commonly used range of immunotherapy drugs is not effective in some patients with Crohn’s disease has so far not been identified, until now.

7 Oct 2019

Acne may be a natural, transient inflammatory state when facial skin is exposed to microbes

Adolescent acne does not always result in a pathological condition; rather, it may be a natural, transient inflammatory state occurring when the maturing facial skin is exposed to new microbes and enhanced production of an oily substance called sebum, according to a Forum article published on September 26 in the journal Trends in Immunology.

25 Sep 2019

New therapeutic target for rheumatoid arthritis and type 2 diabetes

There is a growing body of knowledge that points that type 2 diabetes, a chronic disease where the blood sugar increases, is an inflammatory disease. The levels of certain inflammatory chemicals, dubbed as cytokines, are often higher in people with type 2 diabetes, than healthy people.

16 Sep 2019

New biomarkers help predict response to treatment in common brain tumor

Many scientists have noted that there is a link between inflammation or the immune response, and patient survival. One such possible relationship is the association of blood markers and the prognosis in the brain tumor called medulloblastoma.

16 Sep 2019

Common IBD drugs not linked to increased risk of serious infections in children

In a new register-based study, Swedish and Danish researchers show that common drugs for Inflammatory Bowel Disease, so-called TNF-α inhibitors, are not linked to increased risk of serious infections in children. Previous studies have shown an increased risk in corresponding adult patients.

5 Sep 2019

Combination therapy for rheumatoid arthritis may lead to higher remission rates

Researchers at the University of North Carolina Chapel Hill and RTI International, a nonprofit research institute, recently found that patients with early rheumatoid arthritis (RA) may see less disease activity and higher remission rates after biologic therapy plus methotrexate (MTX) rather than either treatment alone.

22 Aug 2019

Study uncovers potential new treatment approach for lung cancer

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway.

19 Aug 2019

Researchers identify genes linked to death from sepsis in mice

Sepsis is a life-threatening condition that occurs when the body's immune response to infection spirals out of control.

23 Jul 2019

Using popular anticonvulsant drug to thwart inflammation

Serious conditions, including sepsis, stem from inflammation in the body, and there is a lack of effective medication for sepsis.

2 Jul 2019

Women's pre-pregnancy obesity changes breast milk contents which can affect infant growth

In the first study of its kind, LSU Health New Orleans researchers report that women's pre-pregnancy overweight or obesity produces changes in breast milk, which can affect infant growth.

14 Jun 2019

Research suggests new way to improve the efficacy of arthritis drug

Attaching a removable lock to an arthritis drug can make it safer and more effective, according to a new study publishing June 13 in the open-access journal PLOS Biology led by Wen-Wei Lin of Kaohsiung Medical University, Taiwan.

From PLOS ONE 14 Jun 2019

Researchers uncover new mechanism by which cells communicate in inflammatory processes

A research group from MedUni Vienna and CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences has discovered a new mechanism by which cells communicate in inflammatory processes.

14 Jun 2019

Pre-pregnancy maternal obesity may affect growth of breastfeeding infants

A pioneering new study suggests that babies born to obese or overweight women fail to grow properly during breastfeeding.

14 Jun 2019

Sofrito cooking technique releases healthy nutrients

Researchers have come up with a new study that reveals that cooking vegetables in the sofrito (sauté) with extra virgin olive oil could release certain bioactive compounds from the garlic, onion and tomatoes that could be beneficial for the body.

13 Jun 2019

New computational framework reveals impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice.

10 May 2019

HSS researchers provide better understanding of the cellular mechanisms driving rheumatoid arthritis

Newly identified subsets of cell types present in joint tissue in people with rheumatoid arthritis and how they interact may explain why only some people respond to existing medications, according to two studies by co-senior author Laura Donlin, PhD, Co-Director of the Derfner Foundation Precision Medicine Laboratory at Hospital for Special Surgery and collaborating colleagues.

10 May 2019

Researchers identify circulating proteins associated with progression of diabetic kidney disease

In a breakthrough study published today in Nature Medicine, researchers at Joslin Diabetes Center have identified a group of 17 circulating inflammatory proteins that are consistently associated with the development and progression of diabetic kidney disease.

23 Apr 2019

Japanese researchers explain how inflammation causes gastric tumors

In 1982, researchers reported a link between chronic gastritis and stomach bacterium Helicobacter pylori, triggering a flurry of research into this newly-identified pathogen.

16 Apr 2019

Tumor Necrosis Factor News and Research

Discovery sheds light on TNFα protein's role in impairing memory in Alzheimer's disease

Study identifies genetic marker which could personalize treatment for Crohn's disease

Common genetic variant explains why immunotherapy often fails in Crohn's disease

Acne may be a natural, transient inflammatory state when facial skin is exposed to microbes

New therapeutic target for rheumatoid arthritis and type 2 diabetes

New biomarkers help predict response to treatment in common brain tumor

Common IBD drugs not linked to increased risk of serious infections in children

Combination therapy for rheumatoid arthritis may lead to higher remission rates

Study uncovers potential new treatment approach for lung cancer

Researchers identify genes linked to death from sepsis in mice

Using popular anticonvulsant drug to thwart inflammation

Women's pre-pregnancy obesity changes breast milk contents which can affect infant growth

Research suggests new way to improve the efficacy of arthritis drug

Researchers uncover new mechanism by which cells communicate in inflammatory processes

Pre-pregnancy maternal obesity may affect growth of breastfeeding infants

Sofrito cooking technique releases healthy nutrients

New computational framework reveals impact of arthritis drugs on gene expression

HSS researchers provide better understanding of the cellular mechanisms driving rheumatoid arthritis

Researchers identify circulating proteins associated with progression of diabetic kidney disease

Japanese researchers explain how inflammation causes gastric tumors

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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