Tumorigenesis is the process involved in the production of a new tumor or tumors.
An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at.
In hospitals, doctors often advise patients to take calcium supplements. But does the calcium get into the cells that need it? Until recently, it's been hard to tell.
The European Commission has officially established Euro-BioImaging - which provides life scientists with open access to a broad range of technologies and resources in biological and biomedical imaging - as a European Research Infrastructure Consortium.
Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system.
Cancer metastasis, which is the propagation of tumor cells into distant organs, is the leading cause of cancer patient mortality.
A new study has shown that glial cells of the gut (part of the enteric nervous system) when exposed to secretions from colon cancer cells are convert into tumours themselves. These altered glial cells then convert into promoters of tumours said the study researchers.
Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have just described for the first time the crucial involvement of a cell membrane protein in the development and progression of liver cancer, according to an article published in the Journal of Hepatology.
Sarcomas - cancers that arise from transformed mesenchymal cells (a type of connective tissue) - are quite deadly. Gastrointestinal stromal tumors are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.
New results from researchers at MedUni Vienna's Center for Pathobiochemistry and Genetics show that a protein called mTORC2, which is the target of newly developed cancer drugs, is not even active in colorectal cancer. mTORC2 activity was only found in certain immune cells, which actually need this protein to fight cancer cells.
Among the most deadly killers in the area of cancer, breast cancer is also extremely difficult to treat, once it has spread to the bones. Not only does it metastasize rapidly, but it comprises a variety of cell types and also depends on the input from many other non-breast cells during the initiation, growth and spread of the cancer. This complexity makes it more difficult to develop targeted therapies in this condition.
The identification of oncogenic mutations has provided further insights into the tumorigenesis of meningioma and the possibility of targeted therapy.
AMSBIO have introduced a new range of proprietary reagents designed for researchers investigating targeted cancer therapy.
In a new study published in American Journal of Human Genetics, a team of researchers led by Charis Eng, M.D., Ph.D., Chair of Cleveland Clinic's Genomic Medicine Institute, identified a metabolite that may predict whether individuals with PTEN mutations will develop cancer or autism spectrum disorder.
Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3.
Small-cell clones in proliferating epithelia – tissues that line all body surfaces – organize very differently than their normal-sized counterparts, according to a recent study from the Stowers Institute for Medical Research.
New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase.
A study performed at the Institute for Research in Biomedicine and published in the journal Nature Communications demonstrates that inhibition of the p38 protein boosts the formation of blood vessels in human and mice colon cancers.
Smoking has long been the biggest cause of cancer in the United States, but obesity, now the second leading cause, has been gaining ground.
Activins are proteins involved in a number of important biological functions, including the regulation of the menstrual cycle, cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function.
In 1982, researchers reported a link between chronic gastritis and stomach bacterium Helicobacter pylori, triggering a flurry of research into this newly-identified pathogen.