Tumorigenesis is the process involved in the production of a new tumor or tumors.
Canadian scientists have achieved a first in the study of telomerase, an essential enzyme implicated in aging and cancer.
Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.
Understanding the genetic mutations and protein changes that take place in the progression of cancer is key to its treatment. Mutations in the gene TP53 and concomitant mutant p53 proteins in cancer cells have become notorious over the course of multiple studies of several different types of cancers.
Multiple sclerosis is known as "the disease with a thousand faces" because symptoms and progression can vary dramatically from patient to patient.
In every MS patient cells of their body's own immune system migrate to the brain, where they destroy the myelin sheath.
Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem.
The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.
What goes on inside and between individual cells during the very earliest stages of tumor development? Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells.
A protein that helps colorectal cancer cells spread to other parts of the body could be an effective treatment target.
Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does, and how the two may be involved in cancer.
Scientists from Far Eastern Federal University, University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression.
A team of investigators has recently discovered that the collagen receptor DDR1 functionally interacts with the insulin-like growth factor system in regulating bladder cancer.
A study led by The University of Texas MD Anderson Cancer Center furthered understanding about mitochondria, the cell components known as the "powerhouse of the cell." Knowing more about the genome is crucial given that mitochondria play important roles in tumorigenesis.
Can staph microbes lead to cancer? Microbes are known to affect digestion, mood and overall health, and now Princeton researchers have shown that a shift in the microbiome is linked to cancer -- at least in a threatened subspecies of foxes found only on one island off the California coast.
Adding a medication used to treat epilepsy, bipolar disorder and migraines to a blood pressure medicine reversed some aspects of breast cancer in the offspring of mice at high risk of the disease because of the high fat diet fed to their mothers during pregnancy.
Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.
Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system.
An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at.
In hospitals, doctors often advise patients to take calcium supplements. But does the calcium get into the cells that need it? Until recently, it's been hard to tell.
The European Commission has officially established Euro-BioImaging - which provides life scientists with open access to a broad range of technologies and resources in biological and biomedical imaging - as a European Research Infrastructure Consortium.