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Scientists discover how resistance to the chemotherapy drug 5-fluorouracil arises

Australian researchers have unlocked the mystery as to why the chemotherapy drug 5-Fluorouracil is not effective at treating certain cancers.

17 Jul 2019

Study reports significant link between exposure to inorganic dust and gout in women

The results of a study presented today at the Annual European Congress of Rheumatology demonstrate that occupational exposure to inorganic dust is a previously unknown risk factor for gout and also confirm known risk factors, such as alcoholism and obesity.

12 Jun 2019

Removing damaged mitochondria may relieve chronic inflammatory conditions

Researchers have discovered a potential new way to treat chronic inflammatory diseases, by eliminating damaged mitochondria before they trigger excessive inflammation.

12 Apr 2019

Researchers discover unique approach to treat some chronic inflammatory diseases

Inflammation is a balanced physiological response -- the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and chronic diseases.

12 Apr 2019

Success for new cholesterol-lowering drug

A new, oral drug that effectively lowers LDL or "bad" cholesterol, looks set for clinical approval.

14 Mar 2019

Phase III CLL14 study evaluating Venclexta plus Gazyva to treat CLL meets its primary endpoint

Genentech, a member of the Roche Group , announced today that the randomized Phase III CLL14 study, which evaluated fixed-duration Venclexta® in combination with Gazyva® in people with previously untreated chronic lymphocytic leukemia and co-existing medical conditions, met its primary endpoint and showed a statistically significant reduction in the risk of disease worsening or death compared to standard-of-care Gazyva plus chlorambucil.

1 Nov 2018

Scientists find ways to block nitration of amino acids to improve cancer immunotherapy

Immunotherapy -- harnessing T-cells to attack cancer cells in the body -- has given hope to patients who endure round after round of treatment, including chemotherapy, to little effect. For all of its promise, however, immunotherapy still benefits only a minority of patients -- a reality driving research in the field for ways to improve the relatively new approach.

30 Oct 2018

Study: Nurse-led care can be more successful in managing gout

Providing nurse-led care for people suffering with the painful, long-term condition gout could lead to an increase in the number of patients sticking to a beneficial treatment plan, a clinical trial has revealed.

19 Oct 2018

Nutritional quality of breakfast linked to cardiovascular and metabolic risk factors in children

Researchers at the Institute for Innovation and Sustainable Development in the Food Chain of the Public University of Navarre have published a piece of research in which they show that the nutritional quality of breakfast is associated with significant cardiovascular and metabolic risk factors in overweight children (even in those who are fit and who do exercise every day).

16 Oct 2018

Genes cause gout not diet

It has been believed for centuries that a diet rich in red meat and wine is associated with gout. This painful joint disease leads to extremely painful swelling of the joints (mainly of the great toes). This is caused due to elevation of uric acid in blood that gets deposited around the joints causing pain and inflammation.

11 Oct 2018

OSA patients have higher risk of developing gout, research reveals

New research reveals that people with obstructive sleep apnea (OSA) have a higher risk of developing gout, even beyond the first years after being diagnosed with the sleep disorder. The findings are published in Arthritis & Rheumatology, an official journal of the American College of Rheumatology.

30 Aug 2018

CHLA researchers highlight need to include overweight subjects in metabolic research

Children's Hospital Los Angeles investigators have demonstrated the need to include a growing constituency of obese and overweight children and adults in clinical research, with their study of a key marker for metabolism and body temperature control.

23 Aug 2018

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Inflammation is part of the body's natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer's disease and other conditions.

26 Jul 2018

AbbVie submits supplemental NDA to FDA for venetoclax to treat acute myeloid leukemia

AbbVie, a research-based global biopharmaceutical company, today announced it submitted a supplemental New Drug Application to the U.S. Food and Drug Administration for venetoclax in combination with a hypomethylating agent or in combination with low-dose cytarabine for the treatment of newly diagnosed patients with acute myeloid leukemia who are ineligible for intensive chemotherapy.

20 Jul 2018

Canakinumab reduces gout rate by more than half in atherosclerosis patients, study shows

The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate that canakinumab significantly reduced the rate of gout by more than half compared to placebo, regardless of baseline serum urate level.

18 Jun 2018

Study shows improvements in adherence, outcomes of gout patients receiving text message reminders

The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate significant improvements in adherence and clinical outcomes in gout patients who received a daily text message to remind them to take allopurinol.

14 Jun 2018

Kidney stones on the rise among Americans, finds study

According to a new study, there is an increasing incidence of kidney stones among men and women living in the United States. The study is published this week in the latest issue of the journal Mayo Clinic Proceedings.

14 Feb 2018

Self-powered, paper-based electrochemical devices detect biomarkers and identify diseases

A new medical-diagnostic device made out of paper detects biomarkers and identifies diseases by performing electrochemical analyses - powered only by the user's touch - and reads out the color-coded test results, making it easy for non-experts to understand.

22 Aug 2017

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Titanium dioxide, one of the most-produced nanoparticles worldwide, is being used increasingly in foodstuffs.

19 Jul 2017

Combination treatment found to effective in patients with tophaceous gout

The drug lesinurad in combination with febuxostat was better at lowering blood levels of urate than febuxostat alone in a phase III clinical trial of 324 patients with tophaceous gout.

9 Jun 2017