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University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

Researchers at the University of Louisville have received $5.8 million in two grants from the National Institutes of Health to expand their work to better understand and prevent immune system dysregulation responsible for acute respiratory distress, the condition responsible for serious illness and death in some COVID-19 patients.

2 Jun 2023

Stimulating a bile acid receptor can help protect the vision of premature newborns

It sounds like bile acid in the eye would hurt, but scientists think stimulating one of its receptors can actually help protect the vision of premature newborns.

30 May 2023

Unlocking the brain-lung dialogue key to future treatments for critical care patients

Researchers review evidence on the crosstalk between the lung and brain and identified potential areas for further research.

29 May 2023

Study examines the role of hydrocortisone in the management of adult patients with septic shock

Sepsis is a global health priority affecting 55 million patients worldwide and causing 11 million deaths annually. Treatment for sepsis may include prompt recognition, source control, antibiotics, fluids, vasopressors, and adjunctive therapies.

22 May 2023

New guidance recommends the discontinuation of antibiotics after closure of incisions

Antibiotics administered before and during surgery should be discontinued immediately after a patient's incision is closed, according to updated recommendations for preventing surgical site infections.

5 May 2023

Is it possible for the human brain to be activated by the dying process?

Researchers examined the neuronal activity of the dying human brain.

3 May 2023

An overview of mothers’ lived pregnancy experiences during the COVID-19 pandemic

Researchers aimed to understand mothers' experiences of pregnancy during the COVID-19 pandemic.

24 Apr 2023

Hospitals need to establish antimicrobial stewardship programs to prevent C. difficile infections

Five medical organizations say it is essential that hospitals establish antimicrobial stewardship programs to prevent Clostridioides difficile (C. difficile) infections.

12 Apr 2023

Specific proteins in the blood may help predict which COVID-19 patients may become critically ill

Researchers at Washington University School of Medicine in St. Louis have identified specific proteins that may help predict which COVID-19 patients may need to be placed on ventilators to breathe and which are most likely to die of the virus.

6 Apr 2023

Poor inflammatory immune response in obese patients increases susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

20 Mar 2023

Study finds community-onset bacterial coinfection in children with critical COVID-19 is infrequent but empiric antibiotics are commonly prescribed

Researchers evaluated the use of empiric antibiotics to determine the prevalence rates of community-acquired bacterial coinfections among hospitalized pediatric critical COVID-19 patients.

8 Mar 2023

The safety of short-course compared to long-course antibiotic therapy for ventilator-associated pneumonia

Researchers performed a meta-analysis of randomized controlled trials to evaluate the safety of short-course antibiotic treatment versus long-course antibiotic treatment for ventilator-associated pneumonia.

7 Mar 2023

25% of COVID-19 patients have lasting reduction in lung function

In a recent study posted to the Preprints with The Lancet SSRN* server, researchers evaluated the impairment of pulmonary function in individuals suffering from post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) or long coronavirus disease (long COVID) symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

28 Feb 2023

California requires hospitals to turn to a patient’s next of kin, closing a longtime loophole

About four years ago, Dr. Gene Dorio sat on the ethics committee of a Southern California hospital whose administrators insisted they could decide whether to disconnect a ventilator from an unconscious patient — even though the man's wife and adult children wanted to continue life support.

17 Feb 2023

As opioids mixed with animal tranquilizers arrive in Kensington, so do alarming health challenges

Many people living on the streets in Philadelphia's Kensington neighborhood — the largest open-air drug market on the East Coast — are in full-blown addiction, openly snorting, smoking, or injecting illicit drugs, hunched over crates or on stoops. Syringes litter sidewalks, and the stench of urine fouls the air.

15 Feb 2023

Rockefeller scientists describe the genetics of severe SARS-CoV-2 infection in children

One of the most terrifying aspects of the COVID pandemic has been its unpredictably severe impact on some children.

10 Feb 2023

Comparison of pre- and post-Omicron disease severity among unvaccinated people without risk factors

In a recent study posted to the medRxiv* preprint server, researchers in Sweden investigated coronavirus disease 2019 (COVID-19) severity among unvaccinated adults during the periods of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) dominance compared to the severity of pre-Omicron VOC infections.

8 Feb 2023