Whole Genome Sequencing News and Research

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Gut bacteria can influence how cancer responds to immunotherapy

Bacteria that live in the human digestive tract can influence how cancer responds to immunotherapy, opening a new avenue for research to improve treatment, a team led by researchers at The University of Texas MD Anderson Cancer Center reports in the journal Science.

2 Nov 2017

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope, and the Keck School of Medicine of the University of Southern California.

27 Oct 2017

Better post-weaning diet can reverse potential consequences of early-life high-fat exposure

Research has shown that a mother's diet during pregnancy, particularly one that is high-fat, may program her baby for future risk of certain diseases such as diabetes. A new study from nutrition researchers at the University of Illinois shows that switching the offspring to a new diet--a low-fat diet, in this case--can reverse that programming.

20 Oct 2017

Whole genome sequencing could help better understand genetic abnormalities underlying autism

An analysis of the complete genomes of 2,064 people reveals that multiple genetic variations could contribute to autism. The work suggests that scanning whole genomes may one day be useful for clinical diagnostics.Autism has genetic roots, but most cases can't be explained by current genetic tests.

12 Oct 2017

Existing drugs could help patients with rare form of bone cancer

Patients with a rare bone cancer of the skull and spine - chordoma - could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust.

12 Oct 2017

New serotypes of Zika virus could appear in near future, researcher cautions

Zika virus is mutating so fast in Brazilian patients that different serotypes of the pathogen could appear in the near future, as is already the case with dengue virus. This would hinder the production of a vaccine and impair the effectiveness of the diagnostic tests already developed.

10 Oct 2017

Five new ways individualized medicine has moved from research lab into clinical care

Advancements in individualized medicine are offering health care providers new tools to quickly and accurately diagnose, treat, predict and, eventually, prevent disease. Keith Stewart, M.B., Ch.B., Carlson and Nelson Endowed Director, Mayo Clinic Center for Individualized Medicine, today outlined five new ways individualized medicine has moved from the research lab into clinical care. Dr. Stewart made his statements during the opening of the 2017 "Individualizing Medicine Conference: Advancing Care Through Genomics" in Rochester.

9 Oct 2017

Study sheds new light on underlying genetic causes of congenital heart disease

Approximately one in every 100 babies is born with congenital heart disease (CHD), and CHD remains the leading cause of mortality from birth defects.

9 Oct 2017

Immunotherapy could help some breast cancer patients based on genetic changes in their tumors

Immunotherapy drugs could help some breast cancer patients based on the genetic changes in their tumors, researchers at the Wellcome Trust Sanger Institute and their collaborators find.

13 Sep 2017

Genome sequence cannot predict radiation resistance, say researchers

For the last two decades, researchers worldwide have been using whole genome sequencing to understand what makes cells radiation-resistant, hoping to solve an old biological mystery: why is it that one of the most radiation-resistant organisms, Deinococcus radiodurans, aka "Conan the bacterium," can survive hundreds of times more DNA damage caused by gamma rays than most other organisms? According to a study published recently in Standards of Genomic Sciences by researchers at the Uniformed Services University (USU), the amount of radiation a Deinococcus cell can survive in fact has little to do with the number and types of its DNA repair proteins.

11 Sep 2017

Generation Genome: the UK’s genetics revolution?

The report set out the NHS’ intentions of routinizing whole genome sequencing. It is particularly focused towards rare diseases and cancers, although conditions such as obesity, bacterial and other infections are also included.

11 Sep 2017

Machine learning and whole-genomic sequence data could predict physical traits including the face for identification study reveals

A study conducted by a team of researchers from Human Longevity, Inc. (HLI) found that whole-genome sequencing data and machine learning can be used in the prediction of individual faces and other physical traits.

8 Sep 2017

Study shows how breast cancer cells spread late in disease development

Breast cancer cells that spread to other parts of the body break off and leave the primary tumor at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

14 Aug 2017

PerkinElmer introduces affordable clinical genomics services

PerkinElmer, Inc. , a global leader committed to innovating for a healthier world, today announced the launch of PerkinElmer Genetics' clinical genomics services.

3 Aug 2017

Expert outlines pros and cons of ordering various genetic tests

The amount of information gathered via next-generation sequencing has made the diagnosis of genetic disorders quicker and more accessible to clinicians than ever before, but with expanded testing options come questions about ordering the correct type of testing.

2 Aug 2017

Multistate Salmonella outbreak linked to Maradol Papaya: CDC reports

A total of 47 people have been infected with Salmonella Kiambu infections from 12 different states as of 21st July 2017, reports the CDC. Of these, 12 have had to be hospitalized and one person from New York City succumbed to the infection. Maradol papayas have been found to be the likely source of this infection and the CDC has recommended people not to consume these until its clear.

24 Jul 2017

Methicillin use not to blame for MRSA, say researchers

The introduction of methicillin into clinical practice is not what caused the emergence of methicillin resistant Staphylococcus aureus (MRSA), report researchers. According to a collaborative study by the University of St Andrews, University of Dundee and the Wellcome Trust Sanger Institute, MRSA existed long before clinicians started using the antibiotic.

20 Jul 2017

Large-scale genetic study of E. coli illustrates complexity of drug resistant 'superbugs'

The first large-scale genetic study of Escherichia coli (E. coli) cultured from patients with bloodstream infections in England showed that drug resistant 'superbugs' are not always out-competing other strains.

18 Jul 2017

DNA links deadly germs, tainted heart surgery devices to German factory

Contamination at a German factory that makes crucial machines used during open-heart surgery is the likely source of a global outbreak of deadly infections tied to the devices, the largest analysis to date shows.

12 Jul 2017

Study shows potential of whole genome sequencing and AI to help clinicians scale precision oncology

In a study published today in the July 11, 2017 issue of Neurology Genetics, an official journal of the American Academy of Neurology, researchers at the New York Genome Center, The Rockefeller University and other NYGC member institutions, and IBM have illustrated the potential of IBM Watson for Genomics to analyze complex genomic data from state-of-the-art DNA sequencing of whole genomes.

11 Jul 2017