Yellow Fever News and Research

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Yellow fever virus, a flavivirus, is transmitted to humans through the bite of infected mosquitoes. Illness ranges in severity from a self-limited febrile illness to severe hepatitis and hemorrhagic fever. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever include use of insect repellent, protective clothing, and vaccination. Yellow fever occurs in tropical regions of Africa and in parts of South America. Yellow fever is a very rare cause of illness in U.S. travelers. The last epidemic of yellow fever in North America occurred in New Orleans in 1905.

Coronavirus deranges the immune system in complex and deadly ways

There's a reason soldiers go through basic training before heading into combat: Without careful instruction, green recruits armed with powerful weapons could be as dangerous to one another as to the enemy.

4 Mar 2021

Research shows how antibodies attach to and block Zika virus

The Zika outbreak of 2015 and 2016 are having lasting impacts on children whose mothers became infected with the virus while they were pregnant.

25 Feb 2021

A machine-learning approach to track how yellow fever mosquito moves through the environment

The yellow fever mosquito (Aedes aegypti) is a main vector of deadly diseases like dengue fever, chikungunya, and the Zika virus, which result in hundreds of thousands of deaths worldwide each year.

24 Feb 2021

Researchers develop models to predict epidemics of yellow fever, other mosquito-borne diseases

Yellow fever was the first human disease to have a licensed vaccine and has long been considered important to an understanding of how epidemics happen and should be combated.

23 Feb 2021

International health organizations establish global Ebola vaccine stockpile

The four leading international health and humanitarian organizations announced today the establishment of a global Ebola vaccine stockpile to ensure outbreak response.

18 Jan 2021

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers from Boston University School of Medicine provide a new genomics resource that details the small RNA transcriptomes (gene expression) of four bio-medically important mosquito species.

13 Jan 2021

Is one-dose COVID-19 vaccination better than two?

A recent study published on the preprint server medRxiv in December 2020 reflects on the possibility of using a single-dose vaccine regimen to accomplish large-scale vaccination as early as possible.

6 Jan 2021

Asian tiger mosquito does not pose a major risk for Zika virus epidemics

The Asian tiger mosquito does not pose a major risk for Zika virus epidemics, according to a study published December 31 in the open-access journal PLOS Pathogens by Albin Fontaine of the Institut de Recherche Biomédicale des Armées, and colleagues.

4 Jan 2021

$3.7 million NIH grant supports development of biosensor technology for diagnosing viral diseases

For over ten years, Ali Yanik has been working to develop novel biosensor technology to provide rapid, low-cost testing for disease diagnostics and precision medicine.

16 Dec 2020

Study: TMEM41B transmembrane protein is a critical factor for SARS-CoV-2 replication

A single protein that appears necessary for the COVID-19 virus to reproduce and spread to other cells is a potential weakness that could be targeted by future therapies.

10 Dec 2020

Virginia Tech researchers awarded NIH grant to develop Zika virus vaccine

Flaviviruses -- a group of viruses transmitted by ticks or mosquitoes -- infect an estimated 400 million people annually with diseases like yellow fever, Dengue fever, West Nile virus, and, most recently, Zika virus.

9 Dec 2020

A new potential COVID-19 vaccine candidate: YF-S0

A recent study published in the journal Nature describes the safety and efficacy of a live-attenuated yellow fever 17D (YF17D) vector-based vaccine candidate expressing a non-cleavable form of the spike protein of severe acute respiratory coronavirus 2 (SARS-CoV2).

2 Dec 2020

KU Leuven vaccine candidate works against yellow fever and SARS-CoV-2 infection

Virologists at the Rega Institute at KU Leuven (Belgium) have developed a vaccine candidate against Covid-19 based on the yellow fever vaccine, which as a result also works against yellow fever. Results published today in Nature show that the vaccine protects hamsters from infection with the SARS-CoV-2 coronavirus after a single dose.

1 Dec 2020

Dopamine-release mechanisms in the brain may play a major role in SARS-CoV-2 infection

The study, which appeared in the Journal of Taibah University Medical Sciences, shows that the SARS-CoV-2 may behave akin to the CNS pathogenic mechanism of JEV and HIV during the early stages of infection.

15 Nov 2020

High prevalence of cross-reactive anti-SARS-CoV-2 antibodies in sub-Saharan Africa

A recent study published in the International Journal of Infectious Diseases has explained the lower prevalence of coronavirus disease 2019 (COVID-19) in sub-Saharan Africa compared to that in the US, Europe, and Asia.

15 Nov 2020

VA joins Pentagon in recruiting volunteers for COVID vaccine trials

The Department of Veterans Affairs is recruiting 8,000 volunteers for the Phase 3 clinical trials of at least four COVID-19 vaccine candidates at 20 federal medical facilities across the U.S., according to officials with the VA and Operation Warp Speed, the Trump administration's initiative to fast-track a coronavirus vaccine.

6 Nov 2020

Genomic surveillance of yellow fever outbreak in São Paulo

Yellow fever virus is normally confined to the Amazon region, but the virus circulated in the Southeast of Brazil between 2016 and 2018, causing the worst epidemic and epizootic outbreaks there for decades.

5 Nov 2020

Study shows T cells can prevent Zika infection in mice

Where Aedes mosquitoes fly, Zika virus may not be far behind. Although the explosive 2015–2016 Zika epidemics in the Americas are behind us, Zika may re-emerge, and "in many countries, Zika may be spreading in silence," says Sujan Shresta, Ph.D., a professor at La Jolla Institute for Immunology (LJI).

5 Nov 2020

Nigeria safely relaunches accelerated yellow fever vaccination campaigns

While combatting multiple public health challenges, including the COVID-19 pandemic, the Government of Nigeria, with support of the World Health Organization (WHO) and Gavi, the Vaccine Alliance will safely relaunch an accelerated series of mass preventive vaccination campaigns to protect Nigerians against yellow fever (YF).

23 Oct 2020

Increasing levels of light pollution could impact transmission of diseases through mosquitoes

Artificial light abnormally increases mosquito biting behavior at night in a species that typically prefers to bite people during the day, according to research from the University of Notre Dame that was published in The American Journal of Tropical Medicine and Hygiene.

21 Oct 2020