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AAPS recognizes top scientists in pharmaceutical sciences

During the Opening Session of the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, AAPS President David Y. Mitchell, Ph.D., presented the following ground-breaking researchers with awards commemorating their contributions to the pharmaceutical sciences:

15 Oct 2012

Downregulated protein could be revascularization target in critical limb ischemia

Levels of calcium-sensor protein, S100A1, are downregulated in patients with critical limb ischemia, say researchers who believe the protein could be a potential therapeutic target to promote revascularization.

12 Oct 2012

Two CUMC studies provide new insights into spinal muscular atrophy

A study by scientists from the Motor Neuron Center at Columbia University Medical Center (CUMC) suggests that spinal muscular atrophy (SMA), a genetic neuromuscular disease in infants and children, results primarily from motor circuit dysfunction, not motor neuron or muscle cell dysfunction, as is commonly thought.

12 Oct 2012

Inscopix to introduce nVista HD at Neuroscience 2012

Inscopix, Inc. will announce the launch of nVista HD, an end-to-end solution for in vivo brain imaging in freely behaving mice, this weekend at Neuroscience 2012 (SfN).

11 Oct 2012

Researchers develop interference therapies to knock down gene that drives MCL

Three thousand new cases of Mantle Cell Lymphoma (MCL), a form of blood cancer, appear in the United States each year. With a median survival span of only five to seven years, according to the Leukemia and Lymphoma Society, this disease is devastating, and new therapies are sorely needed.

From Integrated DNA Technologies 11 Oct 2012

PARP-1 plays a major role in controlling AR function in prostate cancer patients

A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson's Kimmel Cancer Center researchers suggests.

10 Oct 2012

PENTAX Medical to release new EPK-i7000 video processor and i10 series endoscopes

PENTAX Medical, a healthcare industry leader in endoscopic imaging, will release the next generation High Definition (HD+) EPK-i7000 video processor and i10 series endoscopes during the United European Gastroenterology week from October 20-24, 2012 in Amsterdam, The Netherlands.

From PENTAX Medical Company 9 Oct 2012

HPV status predicts oropharyngeal cancer irradiation response

Human papillomavirus-positive head and neck cancer is more sensitive to the initial effects of radiation therapy than HPV-negative head and neck cancer, suggest study findings.

8 Oct 2012

ImaginAb enters into neurodegeneration research collaboration agreement with Lundbeck

ImaginAb, Inc., a clinical-stage company developing in vivo molecular imaging agents based on antibody fragment technology, today announced that it has entered into a collaboration and commercialization agreement with H. Lundbeck A/S.

8 Oct 2012

NCI awards Cellerant SBIR contract to develop Megakaryocyte Progenitor Cell therapy for thrombocytopenia

Cellerant Therapeutics Inc., a biotechnology company developing novel hematopoietic stem cell-based cellular and antibody therapies for blood disorders and cancer, announced today that it has been awarded a Small Business Innovation Research (SBIR) Phase 1 contract and a Phase 2 option from the National Cancer Institute (NCI) valued up to $1,683,503.

8 Oct 2012

Study provides direct evidence for persistent activity in medial entorhinal cortex layer neurons

UCLA researchers have for the first time measured the activity of a brain region known to be involved in learning, memory and Alzheimer's disease during sleep. They discovered that this part of the brain behaves as if it's remembering something, even under anesthesia, a finding that counters conventional theories about memory consolidation during sleep.

8 Oct 2012

CytoDyn announces update on feline immunodeficiency virus therapeutic antibody program

CytoDyn Inc., a biotechnology company focused on the development of new therapies for combating infection with immune deficiency viruses, announced today that it is presenting an update on its Feline Immunodeficiency Virus (FIV) therapeutic antibody program at the 19th West Coast Retrovirus meeting in Palm Springs, California.

8 Oct 2012

Without B-Raf and C-Raf proteins mice's fur turns white

These proteins are required for melanocyte stem cell self-maintenance and, as such, correct pigmentation throughout the mice's life span. Without these two proteins, the mice's fur turns white. Their research is published in the review 'Cell Report' and paves the way for serious possibilities in terms of stopping the formation of melanomas, tumours that originate from melanocyte cells.

6 Oct 2012

Improved small animal Positron Emission Tomography (PET) scanners introduced by IntelLiDrives

In research into human diseases and the search for potential treatments, small animal models play an important role in bridging the gap between in vitro and in vivo studies. IntelLiDrive is at the forefront of small animal PET tomography scanner design.

5 Oct 2012

RXi receives SBIR grant to enable discovery and preclinical development of sd-rxRNAs

RXi Pharmaceuticals Corporation, a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using RNA-targeted technologies, today announced that it was awarded a Small Business Innovation Research (SBIR) grant by the National Cancer Institute (NCI) of the National Institutes of Health (NIH).

5 Oct 2012

Patients with eye diseases can benefit from ArtCornea

Blindness is often caused by corneal diseases. The established treatment is a corneal transplant, but in many cases this is not possible and donor corneas are often hard to come by. In the future, an artificial cornea could make up for this deficiency and save the vision of those affected.

5 Oct 2012

New mouse model could foster ALS, Paget's and dementia breakthroughs

Efforts to treat disorders like Lou Gehrig's disease, Paget's disease, inclusion body myopathy and dementia will receive a considerable boost from a new research model created by UC Irvine scientists.

3 Oct 2012

New positively-charged nanoparticles can be useful MRI agents to monitor transplanted islet cells

In a study to investigate the detection by MRI of six kinds of positively-charged magnetic iron oxide nanoparticles designed to help monitor transplanted islet cells, a team of Japanese researchers found that the charged nanoparticles they developed transduced into cells and could be visualized by MRI while three kinds of commercially available nanoparticles used for controls could not.

3 Oct 2012

Inhibiting TRPV4 protects against diet-induced obesity, inflammation and insulin resistance

Ember Therapeutics, Inc., a company harnessing breakthroughs in brown fat biology and insulin sensitization to revolutionize the treatment of metabolic disease, today announced the publication of key preclinical data demonstrating that inhibition of the Transient Receptor Potential Vanilloid (TRPV) family of ion channels - specifically TRPV4 - resulted in activation of brown/beige fat and protection from diet-induced obesity, inflammation and insulin resistance. Ember holds an exclusive option to license these TRPV4 findings and technology.

28 Sep 2012

EPO grants patent to Rexahn’s new isoquinolinamine compounds for cancer

Rexahn Pharmaceuticals, Inc., a clinical stage pharmaceutical company commercializing potential best in class oncology and CNS therapeutics, today announced that the European Patent Office has granted European patent No. 2099765 to Rexahn, entitled "5, 6, or 7-Substituted-3-arylisoquinolinamine derivatives as antitumor agents."

27 Sep 2012

in vivo News and Research

AAPS recognizes top scientists in pharmaceutical sciences

Downregulated protein could be revascularization target in critical limb ischemia

Two CUMC studies provide new insights into spinal muscular atrophy

Inscopix to introduce nVista HD at Neuroscience 2012

Researchers develop interference therapies to knock down gene that drives MCL

PARP-1 plays a major role in controlling AR function in prostate cancer patients

PENTAX Medical to release new EPK-i7000 video processor and i10 series endoscopes

HPV status predicts oropharyngeal cancer irradiation response

ImaginAb enters into neurodegeneration research collaboration agreement with Lundbeck

NCI awards Cellerant SBIR contract to develop Megakaryocyte Progenitor Cell therapy for thrombocytopenia

Study provides direct evidence for persistent activity in medial entorhinal cortex layer neurons

CytoDyn announces update on feline immunodeficiency virus therapeutic antibody program

Without B-Raf and C-Raf proteins mice's fur turns white

Improved small animal Positron Emission Tomography (PET) scanners introduced by IntelLiDrives

RXi receives SBIR grant to enable discovery and preclinical development of sd-rxRNAs

Patients with eye diseases can benefit from ArtCornea

New mouse model could foster ALS, Paget's and dementia breakthroughs

New positively-charged nanoparticles can be useful MRI agents to monitor transplanted islet cells

Inhibiting TRPV4 protects against diet-induced obesity, inflammation and insulin resistance

EPO grants patent to Rexahn’s new isoquinolinamine compounds for cancer

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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