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Tβ4 may help treat skeletal muscle disease in Duchenne muscular dystrophy

REGENERX BIOPHARMACEUTICALS, INC. announced today that a research team in Washington, D.C. has found that dystrophin-deficient Mdx mice, treated twice a week for six months with Tβ4, showed a significant increase in skeletal muscle regenerating fibers compared to untreated mice. No effects related to muscle function or fibrosis and no adverse reactions were observed in the mice.

6 Feb 2010

iPSC technology for identifying agents that reprogram human somatic cells receives Notice of Allowance

Fate Therapeutics, Inc. received a Notice of Allowance from the United States Patent and Trademark Office for U.S. Patent Application Number 10/997,146 entitled "Methods for Reprogramming Somatic Cells." Upon issuance, the patent will cover foundational induced pluripotent stem cell (iPSC) technology for identifying agents that enable the reprogramming of human somatic cells, including pluripotency genes, small molecules and biologics.

5 Feb 2010

Study: Generic nifedipine product not bioequivalent to Adalat XL

An extended release generic nifedipine product (Mylan-Nifedipine extended release 60 mg formerly Gen-Nifedipine extended release 60mg, Genpharm ULC) is not bioequivalent to the Canadian originator product, Adalat(R) XL(R), according to the results of a study recently published in the International Journal of Clinical Pharmacology and Therapeutics.

4 Feb 2010

CSC, ALS TDI extend collaboration in advancing potential stem cell therapy for ALS

California Stem Cell, Inc. (CSC) and ALS Therapy Development Institute (ALS TDI) are pleased to announce an extension and expansion of their collaboration aimed at advancing a potential stem cell therapy for ALS (amyotrophic lateral sclerosis). This effort will build on work that has already been completed as part of this on-going partnership to understand how stem cells, and their derivatives, may be applied to treatment of this fatal neurodegenerative disease.

3 Feb 2010

Compugen discovers CGEN-15001 protein for treatment of autoimmune disorders

Compugen Ltd. announced today the discovery and experimental validation of CGEN-15001 for the treatment of autoimmune disorders.

2 Feb 2010

Scientists and engineers conduct research on environmental health impacts of nanomaterials

As researchers around the world hasten to employ nanotechnology to improve production methods for applications that range from manufacturing materials to creating new pharmaceutical drugs, a separate but equally compelling challenge exists.

2 Feb 2010

Researchers explore how brain circuitry and learning changes over time

New research shows our brains are a lot more chaotic than previously thought, and that this might be a good thing. Neurobiologists at the University of Maryland have discovered information about how the brain processes sound that challenges previous understandings of the auditory cortex, which had suggested an organization based on precise neuronal maps.

2 Feb 2010

Researchers design bioactive nanomaterial that promotes cartilage growth

Northwestern University researchers are the first to design a bioactive nanomaterial that promotes the growth of new cartilage in vivo and without the use of expensive growth factors. Minimally invasive, the therapy activates the bone marrow stem cells and produces natural cartilage.

1 Feb 2010

Lanzoprazole and astemizole hold promise for early detection of AD

Investigators from the International Center for Biomedicine and the University of Chile, in collaboration with the Center for Bioinformatics of the Universidad de Talca, have discovered that two drugs, the benzimidazole derivatives lanzoprazole and astemizole, may be suitable for use as PET (positron emission tomography) radiotracers and enable imaging for the early detection of Alzheimer's Disease. The study is published in the current issue of the Journal of Alzheimer's Disease.

30 Jan 2010

Docking algorithm EADock allows successful design of new inhibitors for anti-cancer target

Many human tumors express indoleamine 2,3-dioxygenase (IDO), an enzyme which mediates an immune-escape in several cancer types. Researchers in the Molecular Modeling group at the SIB Swiss Institute of Bioinformatics and Dr. Beno-t J. Van den Eynde's group at the Ludwig Institute for Cancer Research Ltd (LICR) Brussels Branch developed an approach for creating new IDO inhibitors by computer-assisted structure-based drug design. The study was presented in the January 2010 online issue of the Journal of Medicinal Chemistry.

30 Jan 2010

New study identifies that SynDIG1 plays critical role in creating and sustaining synapses

A new study from UC Davis Health System identifies for the first time a brain protein called SynDIG1 that plays a critical role in creating and sustaining synapses, the complex chemical signaling system responsible for communication between neurons.

30 Jan 2010

LinkMed’s portfolio company receives order from Siemens AG for DIGNITY Carrier

LinkMed’s portfolio company has received an order from Siemens AG, Health Care Sector, Germany for its patient transportation solution, DIGNITY™ Carrier, for setting up patients for PET/CT imaging for special applications.

29 Jan 2010

Global market for oncology drugs is forecast to reach $80 billion by 2050

New Medicine's Oncology KnowledgeBASE (nm/OK) residing at http://nmok.net became available on the Internet 10 years ago and, since then, the oncology field has evolved into one of the most challenging, complex and promising drug development sectors, both in terms of its potential contribution to medicine and to its market opportunities.

29 Jan 2010

VisEn Medical acquires Bayer Schering Pharma AG's fluorescence agent intellectual property portfolios

VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, announced today that it has acquired the fluorescence imaging agent intellectual property portfolios and related technology platforms from Bayer Schering Pharma AG, Germany.

29 Jan 2010

Leukemia cells rely on fatty acid metabolism to grow and evade cell death

Leukemia cells, like most cancers, are addicted to glucose to generate their energy, but new research shows for the first time that these cells also rely on fatty acid metabolism to grow and to evade cell death.

28 Jan 2010

Adipose tissue, a promising new source of HSPCs

Bone marrow is a leading source of adult stem cells, which are increasingly used for research and therapeutic interventions, but extracting the cells is an arduous and often painful process. Now, researchers have found evidence that fat tissue, known as adipose tissue, may be a promising new source of valuable and easy-to-obtain regenerative cells called hematopoietic stem and progenitor cells (HSPCs), according to astudy prepublished online in Blood, the official journal of the American Society of Hematology.

28 Jan 2010

UC-CCHMC partnership receives $3.75M NIAMS grant for musculoskeletal soft tissue repair research

An award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) will aid a partnership between the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center (CCHMC) in finding new ways to use adult stem cells to speed repair of musculoskeletal soft tissue injuries.

28 Jan 2010

Researchers develop PEG-POD tool for gene therapy

Researchers at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have developed a new tool for gene therapy that significantly increases gene delivery to cells in the retina compared to other carriers and DNA alone, according to a study published in the January issue of The Journal of Gene Medicine.

28 Jan 2010

Top pharmaceutical companies select CRi solutions for drug research and development

Researchers use high resolution genome sequencing to track virulent strain of MRSA

An international team of researchers has used high resolution genome sequencing to track a particularly virulent strain of MRSA as it traveled between South America, Europe and Southeast Asia.

27 Jan 2010

in vivo News and Research

Tβ4 may help treat skeletal muscle disease in Duchenne muscular dystrophy

iPSC technology for identifying agents that reprogram human somatic cells receives Notice of Allowance

Study: Generic nifedipine product not bioequivalent to Adalat XL

CSC, ALS TDI extend collaboration in advancing potential stem cell therapy for ALS

Compugen discovers CGEN-15001 protein for treatment of autoimmune disorders

Scientists and engineers conduct research on environmental health impacts of nanomaterials

Researchers explore how brain circuitry and learning changes over time

Researchers design bioactive nanomaterial that promotes cartilage growth

Lanzoprazole and astemizole hold promise for early detection of AD

Docking algorithm EADock allows successful design of new inhibitors for anti-cancer target

New study identifies that SynDIG1 plays critical role in creating and sustaining synapses

LinkMed’s portfolio company receives order from Siemens AG for DIGNITY Carrier

Global market for oncology drugs is forecast to reach $80 billion by 2050

VisEn Medical acquires Bayer Schering Pharma AG's fluorescence agent intellectual property portfolios

Leukemia cells rely on fatty acid metabolism to grow and evade cell death

Adipose tissue, a promising new source of HSPCs

UC-CCHMC partnership receives $3.75M NIAMS grant for musculoskeletal soft tissue repair research

Researchers develop PEG-POD tool for gene therapy

Top pharmaceutical companies select CRi solutions for drug research and development

Researchers use high resolution genome sequencing to track virulent strain of MRSA

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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