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REPLICor to disclose unique antiviral drug

REPLICor Inc., a privately owned biopharmaceutical company, is developing a broad spectrum antiviral drug called REP 9 which has the broadest spectrum of activity in vitro ever reported for a single chemical entity.

30 Mar 2005

Marker for new blood vessel formation in tumors

In a paper in this month's freely-available online global health journal PLoS Medicine, Roland Haubner and colleagues describe how a compound they have developed can be used together with highly sensitive positron emission tomography (PET) scanning to measure the amount of new blood vessel growth in some tumors.

29 Mar 2005

Onconase granted orphan drug status for malignant mesothelioma in Australia

Alfacell Corporation has announced that the Therapeutic Goods Administration (TGA) in Australia has granted Onconase (ranpirnase) Orphan Drug status for the indication of malignant mesothelioma (MM). Onconase is also designated as an Orphan Drug for MM in Europe.

28 Mar 2005

Tiny scaffolding allows stem cells to become working fat cells

Researchers here have used a new microscopic, three-dimensional scaffolding to coax mouse stem cells to transform themselves into fat cells, and then to function identical to how fat cells naturally do in the body.

22 Mar 2005

Smart nanocarrier technology will cancer treatment

A ‘smart’ nanocarrier technology developed by a team of researchers at the Institute of Bioengineering and Nanotechnology (IBN) is set to vastly improve the way cancer patients are treated.

22 Mar 2005

Fundamental mechanisms that may facilitate the design of safer and more efficacious topical drug delivery systems

In a paper published in the Proceedings of the National Academy of Sciences, a group of researchers led by Samir Mitragotri, a professor of chemical engineering at the University of California, Santa Barbara, reports the identification of fundamental mechanisms that may facilitate the design of safer and more efficacious topical drug delivery systems.

16 Mar 2005

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

In a research report recently published in the Journal of Alzheimer's Disease, published by IOS Press, a research group from the International School for Advanced Studies (ISAS\SISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons.

15 Mar 2005

Most comprehensive genome-wide experimental analyses of sense-antisense transcripts to date

A team of scientists led by Dr. Kuniya Abe from the RIKEN BioResource Center in Japan has performed one of the most comprehensive genome-wide experimental analyses of sense-antisense transcripts to date. Their findings are published in the April issue of the journal Genome Research.

15 Mar 2005

Discovery may provide a new target to treat sepsis

Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase.

14 Mar 2005

RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease.

13 Mar 2005

Thalidomide - new treatment for cancer

Thalidomide, famous in the 60's because of limb deformities in babies born to women who had taken it for morning sickness, was withdrawn in 1961. Now doctors say it could be used as a treatment for cancer.

8 Mar 2005

DNA ejection from single phage particles

Studying phage, a primitive class of virus that infects bacteria by injecting its genomic DNA into host cells, researchers have gained insight into the driving force behind this poorly understood injection process, which has been proposed in the past to occur through the release of pressure accumulated within the viral particle itself.

7 Mar 2005

Scientists re-produce the human body's own cancer-killing cells through gene therapy

New hope to cancer sufferers comes from research by South Korean scientists who have found a way to re- produce the human body's own cancer-killing cells through gene therapy.

1 Mar 2005

New medical devices can cause new immune problems

Medical devices are traditionally thought of as fairly simple implants such as stents and hip replacements – pieces of plastic or metal that are placed in the body to handle a very specific function. But biomedical devices now on the drawing board are considerably more sophisticated and represent an unprecedented melding of man and machine.

28 Feb 2005

Better ways to heal and regenerate bones using microcomputed tomography imaging

Tissue engineers can choose from a wide range of living cells, biomaterials and proteins to repair a bone defect. But finding the optimum combination requires improved methods for tracking the healing process.

20 Feb 2005

Programmed cell death may provide clues to cancer and autoimmune diseases therapies

Dartmouth Medical School geneticists have found links in the cell death machinery of worms and mammals, opening new avenues for studying and targeting a process vital to development and implicated in cancer and autoimmune diseases.

16 Feb 2005

Renovis announces investigational medicine for multiple sclerosis study

Renovis announced today the initiation of a Phase Ia clinical trial for REN-850, an investigational oral small molecule that is being targeted for the treatment of multiple sclerosis (MS).

14 Feb 2005

Inserting corrective genes into the brain to fight Parkinson's disease

An international team of scientists has used gene therapy in two separate studies to renew brain cells and restore normal movements in monkeys and rats with a drug-induced form of Parkinson's disease.

8 Feb 2005

Nano-sized particles enable researchers to visualize a tumor using only infrared light

Nano-sized particles embedded with bright, light-emitting molecules have enabled researchers to visualize a tumor more than one centimeter below the skin surface using only infrared light.

7 Feb 2005

New way to assess the potentially damaging effects of prenatal drug exposure

Scientists have demonstrated a new way to assess the potentially damaging effects of prenatal drug exposure--a technique that could also be used to monitor a fetus's response to therapeutic drugs--using sophisticated, noninvasive medical imaging tools.

7 Feb 2005