Controlled Substances Squared software system

When you have a large number of chemicals, knowing which ones maybe controlled or regulated is a critical but challenging regulatory compliance task.  With large number of regulations to consider including controlled drugs, dual use and chemical weapons convention, export restriction, ozone depletion, PIC etc.

Controlled Substances Squared is a software system that is updated every week and can quickly screen even the biggest chemical collections of millions of chemicals for controlled chemicals from across the globe.

Key features

The software tells you unambigously if, how and where your chemicals are controlled or regulated. It checks all legislative requirements, including all ethers, salts, esters, analogs, stereoisomers, and regulated areas of chemical space.

  • Comprehensive

Encompasses more than 28 countries and international conventions for controlled drugs, chemical weapons and precursors, ozone-depleting, export-controlled chemicals and more.

  • Check any chemical fast

Even works with propriatory and new chemicals. In a single check (.sd, smiles, and inchi), users can upload tens of thousands of chemicals or search by common or chemical name.

  • Powerful yet simple to use

The software is simple to understand and use, even if the users are not compliance experts or chemists. Users can access detailed guidance documents and technical information with a single click.

Upload, draw, or search for chemical structure


Through RESTful, Knime, and Pipeline Pilot, users can automate checks.

Instant access

Web-based with nothing to install.


Experts from Scitegrity are available for help and guidance.


Alerts for upcoming legislation and if a substance's regulated status changes occur.

Availability options


Scitegrity entirely manages the software and does not need anything else during installation.

Scitegrity's business plan is ideal for SMEs and comes with access to web services, a web-based front end, and technical support on an aper user basis.

For bigger organizations, the Cloud enterprise plan comprises unlimited users, dedicated servers, advanced APIs, enterprise authentication, near-instant searches for millions of chemicals, and automatic alerts through the company's FastLookup™ when your compound's regulated status changes. Users can also make their own rules and SOPs.

Controlled Substances Squared software system

Image Credit: Scitegrity 


On-premise is only available with the Enterprise version. This version has all the features of the cloud-based version but is deployed on the user's server and can continuously check compound inventories for controlled substances.

The compound structures do not leave the user's company as it is behind a firewall. However, weekly updates are automatically downloaded and applied. The inventories are then re-checked, and users receive alerts to compliance problems.

Controlled Substances Squared software system

Image Credit: Scitegrity

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