Litesizer DLS delivers best-in-class particle sizing with automated angle selection to prevent errors, while MAPS technology achieves the highest possible peak resolution. Continuous transmittance monitoring identifies sedimentation and agglomeration during measurement, which improves measurement reliability.
The cmPALS and Omega Cuvette are unique to Anton Paar's technology and improve zeta potential accuracy and repeatability by addressing aging effects and reducing the electrical gradient.
Litesizer DLS is equipped with fluorescence and polarization filters, which facilitate not only particle size measurements but also particle concentration assessments in both MAPS three-angle and single-angle modes.
How to use the Litesizer DLS Dynamic Light Scattering Instrument | Quick Start Guide | Anton Paar
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Litesizer DLS 701
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- Particle size measurement ranging from 0.3 nm to 15 µm
- A sophisticated dynamic light scattering device that provides all operational modes
- Fluorescence and polarization filters are available for every angle
- Enhanced resolution through multi-angle particle sizing (MAPS).
- Determination of concentration for up to three distinct size categories
Litesizer DLS 501
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- Particle size analysis ranging from 0.3 nm to 15 µm
- Incorporation of fluorescent and polarization filters for all angles
- Utilization of advanced dynamic light scattering across three measurement angles
- Assessment of zeta potential through patented cmPALS technology
- Measurements of molecular mass and refractive index
Litesizer DLS 301
- Particle sizing from 0.3 nm to 15 µm
- Side-scatter dynamic light scattering for clear samples
- Cost-effective zeta potential measurement with patented cmPALS
- Molecular mass and transmittance measurements
- Ultra-low sample volume down to 1.5 µL
Litesizer DLS 101
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- Particle size measurement ranging from 0.3 nm to 10 µm
- Transmittance assessment for real-time monitoring of sample behavior
- Cost-efficient access to dynamic light scattering
- DLS back-scatter detection guarantees extensive sample coverage
Key features
Three angles, real-time monitoring for better sizing
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Litesizer DLS offers three distinct detection angles for measuring a diverse range of samples, minimizing errors through automatic angle selection.
The Multi-Angle Particle Sizing (MAPS) measurement mode offers outstanding resolution, facilitating advanced analytical accuracy.
Exclusive to the market, continuous transmission monitoring delivers real-time feedback on sample behavior during measurement, offering users immediate information regarding sedimentation or agglomeration. This real-time insight enhances measurement quality and reliability, positioning the system as the ideal choice for precise, reliable particle analysis.
Market-leading zeta potential analysis
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The patented cmPALS technique, used in the dynamic light scattering instrument, is engineered to reduce uncertainties in reproducibility caused by aging effects.
The innovative design of the Omega Cuvette reduces the gradient in the electrical field, which further improves reproducibility (±3 %). With an unparalleled particle size range for zeta potential measurement, spanning from 1.3 nm to 100 µm, our instrument provides the widest capability available, guaranteeing accurate and consistent results across a diverse range of applications.
Kalliope: The benchmark software for particle sizing
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The Kalliope software requires minimal user training.
Measurements can be conducted in just three clicks. A distinctive one-page layout offers an immediate overview of input parameters, measurement signals, and results, providing you with all the necessary information at a glance. Quickly retrieve measurement results through predefined standard reports and structured result summaries.
For more comprehensive analysis, try the customizable report templates, Excel export, and advanced analytical functions. Kalliope is fully compliant with 21 CFR Part 11, ensuring strong data integrity and regulatory compliance.
All the measuring modes need
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Enhance adaptability with the Litesizer DLS 701’s particle concentration measurement mode, which enables calibration-free concentration analysis of up to three distinct size populations within a single sample. This mode accommodates both monodisperse and polydisperse samples over a broad concentration range, whether utilizing single-angle DLS or MAPS.
Users can measure the refractive index of solvents at the precise wavelength and temperature of their measurements (European Patent 3 023 770), guaranteeing optimal accuracy for particle size and zeta potential results. The Litesizer DLS 701 and DLS 501 deliver accurate refractive index measurements within ±0.5 %.
Moreover, the Litesizer DLS series also provides molecular mass measurement.
Most capable filtering options available
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The Litesizer DLS 701 and 501 are the only dynamic light scattering devices available that offer users the distinctive option of using fluorescence and polarization filters in all three angular directions. This capability facilitates particle concentration analysis, as well as MAPS three-angle or specific single-angle analysis with the use of filters, enabling analyses that are unattainable with similar instruments. For instance, the determination of quantum dot concentrations.
Specifications
Source: Anton Paar GmbH
| |
Litesizer
DLS 701 |
Litesizer
DLS 501 |
Litesizer
DLS 101 |
| Particle size specifications |
| Measurement principle |
Dynamic Light Scattering (DLS) |
| Measuring range |
0.3 nm to 15 μm*
(particle diameter) |
0.3 nm to 10 μm*
(particle diameter) |
| Measurement angles |
15 °, 90 °, 175 °, Multi-angle particle sizing (MAPS) |
15 °, 90 °, 175 ° |
175 ° |
| Min. concentration |
0.1 mg/mL (lysozyme)
lower than 0.00001 % (0.1 ppm, Latex 100 nm) |
0.1 mg/mL
(lysozyme) |
| Max. concentration |
50 % w/v (sample-dependent) |
| Min. sample volume |
1.5 µL |
12 µL |
| Accuracy |
Better than +/- 2 % on NIST traceable standards |
| Repeatability |
Better than +/- 2 % on NIST traceable standards |
| Particle Concentration Specifications |
| Analysis model |
Mie Theory |
- |
- |
| Measuring range |
108 - 1013 particles/mL (sample dependent) |
- |
- |
| Size limit |
1 µm |
- |
- |
| Measurement angles |
15 °, 90 °, 175 °, Multi-angle particle sizing (MAPS) |
- |
- |
| Min. sample volume |
12 µL |
- |
- |
| Accuracy |
+/- 10 % (sample dependent) |
- |
- |
| Repeatability |
+/- 5 % (sample dependent) |
- |
- |
| Zeta potential specifications |
| Measuring principle |
Electrophoretic Light Scattering (ELS) / cmPALS |
- |
| Measuring range |
>= +/- 1000 mV |
- |
| Mobility range |
10-11 m2/V.s to 2 x 10-7 m2/V.s |
- |
| Size range |
1.3 nm to 100 µm (diameter) |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Max. sample concentration |
70 % w/v (sample-dependent) |
- |
| Max. sample conductivity |
200 mS/cm |
- |
| Min. sample volume |
50 µL (sample-viscosity-dependent) |
- |
| Accuracy |
Better than +/- 10 % |
- |
| Repeatability |
+/- 3 % |
- |
| Molecular mass specifications |
| Measuring principle |
Static Light Scattering (SLS) |
- |
| Measuring range (mass) |
300 Da to 20 MDa |
- |
| Measuring range (particle size) |
Up to 40 nm (diameter) |
- |
| Measurement angle |
90 ° |
- |
| Min. sample concentration |
0.1 mg/mL (lysozyme) |
- |
| Accuracy |
+/- 10 % |
- |
| Repeatability |
+/- 5 % |
- |
| Transmittance specifications |
| Measuring range |
0 % to 100 % |
| Min. sample volume |
1.5 µL |
15 µL |
| Accuracy |
Better than +/- 1 % |
| Refractive index specifications |
| Measuring range |
1.28 to 1.50 |
- |
| Min. sample volume |
1 mL |
- |
| Accuracy |
+/- 0.5 % |
- |
| General specifications |
| Light source |
Semiconductor laser diode / 40 mW, 658 nm |
| Optical filters (fluorescence, vertical and horizontal polarization) |
Forward, side, and backscattering |
- |
| Laser warm-up time |
6 min |
| Temperature control range |
0 °C to 120 °C |
| Ambient operating temperature |
10 °C to 35 °C |
| Humidity |
Up to 80 % non-condensing |
| Dimensions (W, D, H) |
450 mm, 505 mm, 135 mm |
| Weight |
Approx. 18 kg (40 lb) |
Approx. 16.3 kg (36 lb) |
The Next-Generation Particle Analyzer: Litesizer DLS | Anton Paar
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