The Intabio ZT system integrates icIEF separation and UV detection with high-resolution mass spectrometry to identify peaks. By combining separation, quantification, and direct identification, it helps biopharmaceutical researchers characterize charge variants and proteoforms while minimizing information gaps.
The Intabio ZT system helps users:
- Correlate charge variants with molecular identity
- Define proteoforms with increased certainty
- Examine post-translational modifications
- Enhance the speed of comparability and biosimilar research
- Facilitate the analysis of charge heterogeneity
- Streamline intact and subunit characterization workflows
Key innovations
- Integrated icIEF-UV/MS: Connects imaged charge separation and UV measurement with MS detection
- Microfluidic chip technology: Carries out essential separation, detection, and electrospray operations within a unified cartridge
- Direct peak identification: Aids in minimizing the manual procedures involved in traditional fractionation-based workflows
Ideal applications
- Charge variant analysis
- Monoclonal antibody characterization
- ADC characterization
- Biosimilar development
- Process development
- Protein therapeutics analysis