The Thermo Scientific™ DXR3 SmartRaman™+ Spectrometer was created in close partnership with manufacturers to deliver the sampling versatility, connectivity, and efficiency required by industry. Based on the well-established DXR platform from Thermo Fisher Scientific, the DXR3 SmartRaman+ Spectrometer introduces an enhanced level of accurate, at-line, semi-automated testing while maintaining the reliable performance for which the DXR3 platform is recognized.
Video Credit: Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions
Applications
Pharmaceutical manufacturing: Fill-and-finish testing
The DXR3 SmartRaman+ Spectrometer supports fast and precise quality control through non-destructive analysis, delivering high throughput that can reduce batch release timelines from weeks to just hours.
- Raman technology enables non-destructive measurements through a wide variety of finished packaging, preserving product integrity.
- Automated batch testing minimizes operator effort while accelerating result generation.
- High-resolution capability enables the detection of analytes at low concentration levels.
- Industry-standard OPC UA connectivity ensures smooth integration into existing manufacturing systems.
Image Credit: Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions
Industrial quality control testing
The DXR3 SmartRaman+ Spectrometer improves industrial product quality testing by supporting fast, high-throughput quality inspections. Custom sample holders provide greater sampling flexibility. Its user-friendly design removes the need for specialized Raman expertise, enabling smooth integration into industrial quality control workflows.
Research and method development
The DXR3 SmartRaman+ Spectrometer is well-suited for research and method development activities. Its flexible design accommodates a broad range of applications, with user-interchangeable lasers and the capability to collect spectral data at resolutions exceeding those required for pharmaceutical analysis. This allows accurate characterization of many different sample types, strengthening research and development workflows.
Download the Brochure for More Information
Capabilities
High throughput
Image Credit: Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions
Enhance pharmaceutical manufacturing performance with the DXR3 SmartRaman+ Spectrometer, designed to help products consistently meet defined specifications. With at-line automated sampling and high-throughput analysis, the system improves efficiency during the critical fill-and-finish phase. By providing fast and reliable quality control results, it helps accelerate production timelines, lower labor requirements, and maintain exceptional levels of accuracy and dependability.
Sampling flexibility
Image Credit: Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions
The DXR3 SmartRaman+ Spectrometer provides outstanding sampling flexibility, supporting user-designed, custom multi-sample holders that can accommodate a wide variety of container shapes and sizes, including vials, cuvettes, well plates, and bottles. As a result, the instrument enables non-destructive testing directly through commonly used product containers, preserving sample integrity without requiring any modification to the system.
In addition, the autosampler is factory calibrated to ensure consistent positional reproducibility across multiple autosamplers. This added flexibility expands testing possibilities, while the proven DXR3 platform continues to deliver a high level of accuracy and operational efficiency.
USP and Ph.Eur. validations
Support compliance with stringent industry requirements in pharmaceutical operations using the DXR3 SmartRaman+ Spectrometer. Fully qualified to meet USP and Ph.Eur. quality standards, this instrument enables the execution of required qualification tests within routine validation and maintenance programs. It helps sustain regulatory compliance while supporting consistently high quality across manufacturing processes.
Reduce sample wastage
The DXR3 SmartRaman+ Spectrometer conserves valuable resources by using non-destructive Raman spectroscopy to protect sample integrity and reduce waste. This advanced approach keeps samples in their original condition while providing accurate results without consuming or discarding any tested material.
Measure through containers and packaging
Enable fast and accurate quality control with the DXR3 SmartRaman+ Spectrometer, which supports non-destructive analysis directly through vials, containers, and many other packaging formats. This capability preserves sample integrity, removes the need for sample preparation, and simplifies overall testing workflows.
Download the Brochure for More Information
Features
User-exchangeable lasers
The DXR3 SmartRaman+ Spectrometer offers outstanding versatility through support for interchangeable 532 nm and 785 nm lasers. This adaptability enables accurate analysis across a broad range of sample types, including materials with high fluorescence. Suitable for both quality control use and method development, the DXR3 SmartRaman+ Spectrometer accommodates diverse samples and applications.
Image Credit: Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions
Ease of use
Streamline quality control operations with the DXR3 SmartRaman+ Spectrometer, which combines intuitive hardware with minimal software interaction. Designed to limit reliance on specialized expertise and shorten training requirements, its automated software functions and user-friendly design support rapid adoption and efficient operation in manufacturing settings. The easy-to-operate DXR3 SmartRaman+ Spectrometer helps simplify workflows and improve overall productivity.
Image Credit: Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions
Research-grade data
The DXR3 SmartRaman+ Spectrometer provides research-quality data while maintaining high spectral resolution, measurement accuracy, and user choice of standard excitation wavelengths at 532 nm and 785 nm. Built on the DXR3 platform trusted by experts for more than a decade, the DXR3 SmartRaman+ Spectrometer incorporates durable optical, electronic, and mechanical components to deliver consistent, precise, and dependable results.
Industry-standard OPC UA connectivity
Seamlessly incorporate analytical workflows into manufacturing operations with the advanced connectivity capabilities of the DXR3 SmartRaman+ Spectrometer. Equipped with Open Platform Communications Unified Architecture (OPC UA), a recommended standard for Industry 4.0 connectivity, the DXR3 SmartRaman+ Spectrometer simplifies communication across instruments.
OPC UA enables centralized servers to easily exchange data and commands with equipment from multiple manufacturers and is gaining worldwide adoption as a key interoperability standard that supports manufacturing optimization and digital transformation (DX). With robust connectivity built in, the DXR3 SmartRaman+ Spectrometer is engineered to help maximize operational efficiency while supporting future-ready manufacturing environments.
Although the local software provides essential measurement and experiment setup functions, the instrument is mainly intended to be operated via a local or remote server using OPC UA control, making it well-suited for use in manufacturing settings.
Worldwide service and support
Enhance productivity and maintain optimal performance with Thermo Fisher Scientific’s comprehensive service plans, created to support the DXR3 SmartRaman+ Spectrometer across its full lifecycle. Backed by a global Product and Applications Support program, these services help keep operations efficient and running smoothly in any location.
Exclusive service advantages
- On-site training: Equip teams with practical, expert-led instruction customized to specific operational requirements.
- Unlimited technical support: Receive continuous access to a dedicated technical support team to ensure assistance is always available when needed.
- Extended warranties: Gain added confidence with expanded coverage for the spectrometer.
- Parts-only warranties: Safeguard the investment with warranty options covering critical components.
- System compliance: Easily support ongoing adherence to industry standards.