CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.
CRISPR: Ethical and Safety Concerns

CRISPR and Cas proteins have become a crucial tool for genetic manipulation in biomedical research and biotechnology, and the crux of its action is the recognition of specific sequences in the DNA and their subsequent cleavage from the chain. One specific system, CRISPR-Cas9, has become the standard for genetic editing, since it can be tailored to target any set of DNA sequences. Thus it is of no wonder that it caused an upheaval in biomedical field.

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Overview

Feature Articles

Latest CRISPR News and Research

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

Missing protein triggers alternative immune attack on cancer cells

Missing protein triggers alternative immune attack on cancer cells

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Synthetic biologists develop versatile platform for targeted drug delivery

Synthetic biologists develop versatile platform for targeted drug delivery

New stem cell-based treatment for Type 1 diabetes can reduce dependence on daily insulin injections

New stem cell-based treatment for Type 1 diabetes can reduce dependence on daily insulin injections

SECRE technique paves way for new therapeutics for autoimmune diseases

SECRE technique paves way for new therapeutics for autoimmune diseases

New CRISPR approach shows promise for treating glioblastoma

New CRISPR approach shows promise for treating glioblastoma

Bonn immunologist receives €2 million grant to harness the power of nanobodies for inflammation control

Bonn immunologist receives €2 million grant to harness the power of nanobodies for inflammation control

Scientists uncover key to enhancing cancer-killing T cells

Scientists uncover key to enhancing cancer-killing T cells

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

Bacteria fight phages with RNA-based immune defense

Bacteria fight phages with RNA-based immune defense

New approach to CAR T cell therapy may extend treatment effectiveness

New approach to CAR T cell therapy may extend treatment effectiveness

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Time-lapsed images show how magnesium ions coordinate double-stranded breaks in CRISPR-Cas9

Time-lapsed images show how magnesium ions coordinate double-stranded breaks in CRISPR-Cas9

Gene editing breakthrough could offer new hope for people with phenylketonuria

Gene editing breakthrough could offer new hope for people with phenylketonuria

Science, Innovation, and Xenotransplantation: A Discussion with Dr. Wenning Qin

Science, Innovation, and Xenotransplantation: A Discussion with Dr. Wenning Qin

New gene editing method creates first mice with human-like COVID-19

New gene editing method creates first mice with human-like COVID-19