CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

CRISPR-Based Diagnostics: The Future of Disease Detection

CRISPR-based diagnostics offer transformative solutions for disease detection, utilizing advanced gene-editing tools for precise and rapid molecular testing.

Uses of CRISPR/Cas Biosensing Systems

CRISPR-Cas14: Discovery, Function, Advantages

CRISPR: The End for Zinc Fingers?

What is CRISPR/Cas9?

CRISPR: Ethical and Safety Concerns

Editing Sperm DNA using CRISPR

How Does CRISPR Compare to Other Gene-Editing Techniques?

CRISPR Interference (CRISPRi) for Gene Suppression

CRISPR-Cpf1

Electroporation and the Production of Knockout Mice

Manipulating RNA sequences using CRISPR-Cas13

See more featured articles »

CPISPR Applications

Understanding CRISPR Therapy

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

Unlocking the Potential: CRISPR-Cas9 Gene Editing in Liver Diseases

Latest CRISPR News and Research

Reducing ketone levels and increasing exercise capacity could help manage diabetic ketoacidosis

A researcher at the University of Houston finds management of diabetic ketoacidosis may center around reducing ketone levels in diabetic patients and increasing exercise capacity for better health outcomes.

30 Oct 2025

Unlocking memory: The role of epigenetics in memory expression

Our experiences leave traces in the brain, stored in small groups of cells called "engrams". Engrams are thought to hold the information of a memory and are reactivated when we remember, which makes them very interesting to research on memory and age- or trauma-related memory loss.

29 Oct 2025

Understanding age-related changes in T cells and vaccine response

As flu season approaches and public health officials roll out their annual push for vaccination, Allen Institute scientists are learning why vaccines can trigger a weaker response in older adults, around age 65, and what can be done to improve them.

29 Oct 2025

Nuclear binding protein identified as key contributor to trisomy 21-related CHDs

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

22 Oct 2025

HMGN1 gene linked to heart problems in people with Down syndrome

Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that require surgery in the first months of life.

22 Oct 2025

Epigenetic editing enables safer and more effective T cell therapies

Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that enables safe modification of multiple genes in primary human T cells, addressing a key manufacturing and scalability challenge in next-generation cell therapies.

21 Oct 2025

Researchers engineer a tool to dismantle cancer's RNA-built growth hubs

In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form-but instead of fueling progress, they supercharge disease. That's what researchers at the Texas A&M University Health Science Center (Texas A&M Health) have discovered inside the cells of a rare and aggressive kidney cancer.

21 Oct 2025

Research reveals how immune cells orchestrate the release of toxic granules

When immune cells strike, precision is everything. New research reveals how natural killer and T cells orchestrate the release of toxic granules – microscopic packages that destroy virus-infected or cancerous cells.

17 Oct 2025

Researchers uncover TRAT1's central role in T helper cell function

Researchers at the Medical University of Vienna have taken a closer look at a previously largely unknown component of the immune system: the protein molecule TRAT1 (T Cell Receptor Associated Transmembrane Adaptor 1) plays a central role in how so-called T helper cells (a specialised subgroup of immune cells) distinguish between attack and self-control - an important mechanism for restraining inflammation and preventing autoimmune diseases. The findings have recently been published in the journal Cell Communication and Signaling.

16 Oct 2025

CRISPR therapy shows promise against influenza in human lung chips

The Influenza A virus (IAV) has been the cause of six major flu pandemics, responsible for 50 to 100 million deaths globally.

15 Oct 2025

New research aims to develop targeted therapy for hard-to-treat osteosarcoma

For children and young adults diagnosed with osteosarcoma, a common type of bone cancer for that age group, the odds of survival can be devastatingly low (20-30%) when the disease spreads to the lungs.

15 Oct 2025

Study reveals acidic conditions as key to pancreatic cancer survival

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

9 Oct 2025

Newly discovered mechanism helps leukemia cells to evade the immune system

A research team at Lund University in Sweden has discovered a mechanism that helps acute myeloid leukemia cells to evade the body's immune system.

3 Oct 2025

Harnessing “DNA surgery” to develop therapeutic medicines for genetic liver and heart diseases

Genome editing is increasingly recognized as a leading frontier in biomedical research and an essential driver of healthcare innovation.

30 Sep 2025

Gladstone researchers expand mission to tackle emerging infectious threats

From influenza and COVID-19 to HIV, viruses continue to pose a serious danger to global health.

25 Sep 2025

Genetic modification enhances "living drugs" for blood cancers

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

25 Sep 2025