CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.
What is CRISPR/Cas9?

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

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Overview

Feature Articles

Latest CRISPR News and Research

Study highlights the usefulness of organoids for basic research into coronaviruses

Study highlights the usefulness of organoids for basic research into coronaviruses

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

Defective versions of tumor suppressor genes can help cancer cells evade the immune system

Defective versions of tumor suppressor genes can help cancer cells evade the immune system

Jumpcode Genomics and TGen collaborate on genomic sequencing of SARS-CoV-2

Jumpcode Genomics and TGen collaborate on genomic sequencing of SARS-CoV-2

MD Anderson and SNIPR BIOME join forces to advance new CRISPR-based microbiome therapeutics

MD Anderson and SNIPR BIOME join forces to advance new CRISPR-based microbiome therapeutics

Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

New precision-guided sterile insect technique designed to control disease-spreading mosquitoes

New precision-guided sterile insect technique designed to control disease-spreading mosquitoes

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

UC San Diego researchers receive $6 million NIH grant to study insulin-producing cells

New gene-delivering workhorse could make gene therapy safer, more effective for muscle diseases

New gene-delivering workhorse could make gene therapy safer, more effective for muscle diseases

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Multiplexed electrochemical sensor platform enables simultaneous detection of SARS-CoV-2 RNA and host antibodies

Multiplexed electrochemical sensor platform enables simultaneous detection of SARS-CoV-2 RNA and host antibodies

Researchers develop the smallest CRISPR to date for genome editing

Researchers develop the smallest CRISPR to date for genome editing

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

Uppsala researchers find solution to long-standing biological search enigma

Uppsala researchers find solution to long-standing biological search enigma

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

New research has implications for developing cancer therapies targeting mutant p53 protein

New research has implications for developing cancer therapies targeting mutant p53 protein

Recognizing viral genomes in quick, ‘CRISP’ ways

Recognizing viral genomes in quick, ‘CRISP’ ways

Stiffening of heart’s blood vessels associated with lack of enzyme that fosters cell ‘chatter’

Stiffening of heart’s blood vessels associated with lack of enzyme that fosters cell ‘chatter’