CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

CRISPR-Based Diagnostics: The Future of Disease Detection

CRISPR-based diagnostics offer transformative solutions for disease detection, utilizing advanced gene-editing tools for precise and rapid molecular testing.

CRISPR-Cpf1

Editing Sperm DNA using CRISPR

Uses of CRISPR/Cas Biosensing Systems

CPISPR Applications

Manipulating RNA sequences using CRISPR-Cas13

CRISPR: The End for Zinc Fingers?

Unlocking the Potential: CRISPR-Cas9 Gene Editing in Liver Diseases

What is CRISPR/Cas9?

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

CRISPR: Ethical and Safety Concerns

CRISPR Interference (CRISPRi) for Gene Suppression

See more featured articles »

Electroporation and the Production of Knockout Mice

Understanding CRISPR Therapy

CRISPR-Cas14: Discovery, Function, Advantages

How Does CRISPR Compare to Other Gene-Editing Techniques?

Latest CRISPR News and Research

New gene editing approach improves survival in epileptic mice

In a world first, a research team at the University of Zurich has successfully treated mice carrying an inherited form of epilepsy.

13 May 2026

Researchers uncover nuclear organization mechanism linked to Friedreich's ataxia

Researchers have uncovered a fundamental rule that governs how genes are physically arranged inside the cell nucleus, and how disruptions to that organization can contribute to human disease.

12 May 2026

Large human islet study reveals new insights into diabetes risk

Diabetes is the most common and serious chronic disease worldwide, characterized by insufficient insulin to maintain proper blood glucose levels.

12 May 2026

New AI framework predicts how cells make fate decisions

Scientists at the Stowers Institute for Medical Research, Helmholtz Munich, the Technical University of Munich, and the University of Oxford have developed RegVelo - a new AI framework that simultaneously models cellular dynamics and gene regulation, enabling researchers to predict, simulate, and experimentally validate how cells make fate decisions.

11 May 2026

New CRISPR RNA scissors specifically target and destroy hepatitis E virus

An enzymatic scissors recognizes and cuts viral RNA, but leaves the host cell unharmed. This opens up new antiviral strategies against hepatitis E.

11 May 2026

Researchers uncover how bacterial toxin damages colon lining cells to trigger cancer

Since a landmark 2009 study, researchers have known that a common gut bacterium, Bacteroides fragilis, drives colon tumor formation, potentially leading to colorectal cancer, by secreting a toxin that damages the lining of the colon.

8 May 2026

Engineered regulatory T cells offer a path toward immunosuppression-free transplants

Organ transplantation remains the cornerstone treatment for end-stage organ failure. While conventional broad-spectrum immunosuppression effectively controls acute rejection, it fails to address chronic rejection and carries long-term side effects including infection, malignancy, and metabolic disorders.

8 May 2026

New genetic link found for sudden cardiac death in young people

Short QT syndrome is a genetic disease that leads to sudden cardiac death at a young age. Mutations in the SLC4A3 gene, which regulates bicarbonate-chloride exchange, were recently described as a potential cause. An international research team, including a group from Ruhr University Bochum, Germany, investigated this possibility.

8 May 2026

A breakthrough in understanding how viruses defeat bacterial immunity

Bacteria fend off invading viruses with molecular scissors that slice up viral DNA - a system called CRISPR that's become indispensable to gene editing.

8 May 2026

Chromosome abnormalities may help cancer cells resist treatment and spread

A new study led by NYU Langone Health researchers found that cancer cells are better able to resist treatments when they have an abnormal number of chromosomes, which are DNA strands wound up in bundles that control which genetic instructions are followed in each cell type.

7 May 2026

New CRISPR system selectively destroys cancer cells

Among the challenges in treating disease, including cancer, is wiping out malignancies, infection, contaminants or other pathologies, without destroying healthy tissue.

6 May 2026

Genetic background shapes outcomes in chromosome 16 deletion disorders

Individuals that share the same deletion of a portion of chromosome 16 are at risk of developing neurodevelopmental disorders, but some experience severe intellectual disability or developmental delay, while others may only exhibit milder psychiatric features like depression or anxiety.

5 May 2026

New tools for quicker and easier Mpox diagnosis

Following the rise in monkeypox (Mpox) cases, particularly in countries where the disease had not traditionally been observed, the World Health Organization (WHO) declared a Public Health Emergency of International Concern in June 2022 and again in August 2024.

4 May 2026

Study shows eIF4G2 gene maintains adult intestinal stem cell identity

Years before he conducted the research that would earn him a Nobel Prize in Physiology and Medicine, Shinya Yamanaka, MD, PhD, was a postdoctoral scientist at Gladstone Institutes, studying genes.

30 Apr 2026

AI and CRISPR technologies drive proactive health monitoring

JMIR Publications today featured two new stories in its News and Perspectives section, highlighting a shift toward proactive, tech-integrated health monitoring.

30 Apr 2026

New genetic risk test estimates inherited risk for cardiovascular conditions

Researchers at Mass General Brigham Heart and Vascular Institute and collaborators have developed and validated a new genetic risk test that can estimate a person's inherited risk for eight common cardiovascular conditions, offering a more comprehensive approach to prevention.

29 Apr 2026

Addgene reinforces its expanding role in research with new brand

Addgene, a purpose-driven organization that joins with scientists around the world to reduce barriers to research and foster innovation, today announced that its strategic growth and expanded services have driven the organization’s refreshed brand.

From Addgene 29 Apr 2026

Scientists redesign CAR-T cells to fight more than cancer

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

29 Apr 2026

New human cell model replicates key mechanisms of neurodegenerative diseases

Researchers at LMU have developed a human cell model that replicates key mechanisms of neurodegenerative diseases - with potential for novel therapies.

23 Apr 2026

Common gene in axolotls, mice and zebrafish may unlock human limb regrowth

Investigating a common gene in three very different species – axolotls, mice and zebrafish – scientists have discovered the potential for a novel gene therapy aimed at eventually regrowing limbs in humans, according to new research published this week.

21 Apr 2026