CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

CRISPR-Based Diagnostics: The Future of Disease Detection

CRISPR-based diagnostics offer transformative solutions for disease detection, utilizing advanced gene-editing tools for precise and rapid molecular testing.

Understanding CRISPR Therapy

CRISPR-Cas14: Discovery, Function, Advantages

Editing Sperm DNA using CRISPR

CRISPR-Cpf1

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

Electroporation and the Production of Knockout Mice

CRISPR Interference (CRISPRi) for Gene Suppression

How Does CRISPR Compare to Other Gene-Editing Techniques?

Uses of CRISPR/Cas Biosensing Systems

Unlocking the Potential: CRISPR-Cas9 Gene Editing in Liver Diseases

CPISPR Applications

See more featured articles »

CRISPR: Ethical and Safety Concerns

Manipulating RNA sequences using CRISPR-Cas13

CRISPR: The End for Zinc Fingers?

What is CRISPR/Cas9?

Latest CRISPR News and Research

Study reveals acidic conditions as key to pancreatic cancer survival

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

9 Oct 2025

Newly discovered mechanism helps leukemia cells to evade the immune system

A research team at Lund University in Sweden has discovered a mechanism that helps acute myeloid leukemia cells to evade the body's immune system.

3 Oct 2025

Harnessing “DNA surgery” to develop therapeutic medicines for genetic liver and heart diseases

Genome editing is increasingly recognized as a leading frontier in biomedical research and an essential driver of healthcare innovation.

30 Sep 2025

Gladstone researchers expand mission to tackle emerging infectious threats

From influenza and COVID-19 to HIV, viruses continue to pose a serious danger to global health.

25 Sep 2025

Genetic modification enhances "living drugs" for blood cancers

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

25 Sep 2025

Research shows different EML4-ALK variants drive lung cancer aggressiveness

About five percent of lung adenocarcinomas, one of the most common forms of lung cancer, are driven by a faulty fusion of two genes, EML4 and ALK.

23 Sep 2025

New screening method boosts efficiency and accuracy of CAST genome editing

Natural systems such as CRISPR-associated transposons (CASTs) offer a targetable, one-step way to edit genomes.

23 Sep 2025

Study reveals a new oncogenic role of NBL1 in ovarian cancer metastasis

Ovarian cancer (OC), one of the three most common gynecological malignancies, is characterized by low early detection rates and poor prognosis.

23 Sep 2025

Innovative RNA editing offers hope beyond CRISPR

Genetic editing holds promise to treat incurable diseases, but the most popular method - CRISPR - sometimes does more harm than good.

18 Sep 2025

Loss of key Y chromosome gene causes infertility in male mice

In a new study conducted at the University of Hawaiʻi at Mānoa, researchers from the John A. Burns School of Medicine (JABSOM) have shown that the loss of a key male fertility gene leads to infertility and changes expression of hundreds of other important genes.

17 Sep 2025

CRISPR-based tongue swab test shows promise for tuberculosis detection

Tulane University researchers have developed an enhanced CRISPR-based tuberculosis test that works with a simple tongue swab, a potential breakthrough that could allow easier, community-based screenings for the world's deadliest infectious disease.

17 Sep 2025

CRISPR-GPT helps scientists to generate designs, analyze data and troubleshoot design flaws

Stanford Medicine researchers have developed an artificial intelligence tool to help scientists better plan gene-editing experiments.

16 Sep 2025

CRISPR-based therapeutic approach designed to treat fatal pediatric disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

11 Sep 2025

New technology embeds unique genetic identifiers in engineered cells

Genetically engineered cell lines used in biomedical research have long been prone to misidentification and unauthorized use, wasting billions of dollars each year and jeopardizing critical scientific discoveries.

5 Sep 2025

Nanostructures boost CRISPR delivery for genetic medicine

With the power to rewrite the genetic code underlying countless diseases, CRISPR holds immense promise to revolutionize medicine. But until scientists can deliver its gene-editing machinery safely and efficiently into relevant cells and tissues, that promise will remain out of reach.

2 Sep 2025

Scientists discover molecular brake that limits T cell attack on tumors

In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School have identified a new molecular brake that hinders the ability of T cells to attack tumors.

1 Sep 2025

BindCraft reimagines protein binder discovery through structural prediction

Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to control these interactions is of great interest to biologists.

29 Aug 2025

Inherited DNA changes can cause hormone imbalance in women with polycystic ovary syndrome

Increased testosterone levels are a consistent hormonal abnormality in women with polycystic ovary syndrome (PCOS). This study identified specific DNA variants in the gene DENND1A, which increase testosterone production in PCOS.

29 Aug 2025

Gene editing therapy exa-cel improves quality of life in sickle cell disease and beta thalassemia

Treatment with exagamglogene autotemcel (exa-cel) led to robust and sustained improvements in quality of life for patients with severe sickle cell disease (SCD) or transfusion-dependent beta thalassemia, according to two studies published in Blood Advances.

27 Aug 2025

Study reveals genome rewiring mechanism driving mantle cell lymphoma

Translocations are chromosomal "cut and paste" errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall.

21 Aug 2025