CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

CRISPR-Based Diagnostics: The Future of Disease Detection

CRISPR-based diagnostics offer transformative solutions for disease detection, utilizing advanced gene-editing tools for precise and rapid molecular testing.

Unlocking the Potential: CRISPR-Cas9 Gene Editing in Liver Diseases

CRISPR Interference (CRISPRi) for Gene Suppression

Manipulating RNA sequences using CRISPR-Cas13

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

Uses of CRISPR/Cas Biosensing Systems

How Does CRISPR Compare to Other Gene-Editing Techniques?

Understanding CRISPR Therapy

CRISPR-Cas14: Discovery, Function, Advantages

Electroporation and the Production of Knockout Mice

CRISPR-Cpf1

CRISPR: Ethical and Safety Concerns

See more featured articles »

What is CRISPR/Cas9?

Editing Sperm DNA using CRISPR

CRISPR: The End for Zinc Fingers?

CPISPR Applications

Latest CRISPR News and Research

New funding brings personalized CRISPR cures closer to children with rare diseases

Personalized CRISPR cures for children born with rare genetic diseases are now a step closer to being more widely available.

8 Jul 2025

New gene editing approach targets mutation behind common genetic heart disease

Fourteen million people worldwide suffer from enlarged hearts, or hypertrophic cardiomyopathy (HCM), a genetic disease that thickens the heart's walls, making it harder for the organ to pump blood - but many of them don't know it.

8 Jul 2025

Reversing immune fatigue offers new hope for cancer treatment

CD8⁺ T cells are the immune system's frontline warriors, charged with detecting and eliminating cancer cells. But in the hostile and chronic environment of tumors, these cells often falter.

7 Jul 2025

Synthetic Biology and the Pursuit of Living Diagnostics and Therapeutics

In this interview, Professor James J. Collins, founder of the field of Synthetic Biology, discusses his journey to founding the field of synthetic biology and the potential of living diagnostics.

From Pittcon 7 Jul 2025

XPR1 silencing enhances immune response and reduces ovarian tumor growth

A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating autophagy and MHC-I expression.

4 Jul 2025

Alzheimer’s protein found to drive lung cancer spread to the brain

Researchers at McMaster University, Cleveland Clinic and Case Comprehensive Cancer Center have uncovered how a protein long associated with Alzheimer's disease helps lung cancer spread to the brain – a discovery that offers hope that existing Alzheimer's drugs could be repurposed in preventing cancer's spread.

3 Jul 2025

Breakthrough AI uncovers promising Rett syndrome treatment

Rett syndrome is a devastating rare genetic childhood disorder primarily affecting girls. Merely 1 out of 10,000 girls are born with it and much fewer boys.

2 Jul 2025

Embryos from women with PCOS carry distinctive epigenetic memory

Novel research presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) has found that embryos from women with polycystic ovary syndrome (PCOS) carry a distinctive 'epigenetic memory' that could explain why the condition often runs in families.

1 Jul 2025

Rarely studied RNA linked to triple-negative breast cancer

Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it's also one of the most curable.

1 Jul 2025

Improving RNA drug delivery through intracellular traffic control

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness.

1 Jul 2025

Epigenetic enzyme SETD1B drives aggressive growth in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive cancer affecting the blood and bone marrow that progresses rapidly, making immediate treatment essential.

26 Jun 2025

Scientists use base editing to repair mitochondrial DNA mutations

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor.

25 Jun 2025

UNIGE scientists uncover two key proteins that regulate chromatin remodelling

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated.

24 Jun 2025

New KRAS mutation discovery opens door to targeted colon cancer therapies

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene - a gene that can cause cancer - that may play an important role in colon cancer. Researchers also showed how this mutation could be targeted therapeutically.

24 Jun 2025

New lab method accelerates diagnosis of genetic disorders of the immune system

A new laboratory method developed by researchers at Columbia University Vagelos College of Physicians and Surgeons may now help physicians more quickly diagnose patients with suspected genetic disorders of the immune system, many who have been trapped in diagnostic limbo for years.

20 Jun 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Circular RNAs emerge as key players in hepatitis B-related liver cancer

Hepatitis B virus-induced hepatocellular carcinoma (HCC) remains a major global health burden, and new therapeutic and diagnostic approaches are urgently needed.

20 Jun 2025

NUCDF launches national project to advance urea cycle disorder research

The National Urea Cycle Disorders Foundation, the leading patient advocacy group for people affected by urea cycle disorders (UCDs), today announced the launch of a two-year national project to establish the multistakeholder NUCDF Partner Network and develop a roadmap for future research in these rare disorders.

19 Jun 2025

New gene therapy strategy reactivates dormant genes to treat blood disorders

Researchers have found a promising new method for gene therapy. They successfully restarted inactive genes by bringing them closer to genetic switches on the DNA called enhancers.

19 Jun 2025

Yale researchers triple precision and efficiency in genome editing

The promise of genome editing to help understand human diseases and create new therapies is vast, but technological limitations have limited advancement of the field.

18 Jun 2025