CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

CRISPR-Based Diagnostics: The Future of Disease Detection

CRISPR-based diagnostics offer transformative solutions for disease detection, utilizing advanced gene-editing tools for precise and rapid molecular testing.

CPISPR Applications

Manipulating RNA sequences using CRISPR-Cas13

Unlocking the Potential: CRISPR-Cas9 Gene Editing in Liver Diseases

CRISPR: The End for Zinc Fingers?

Understanding CRISPR Therapy

CRISPR-Cas14: Discovery, Function, Advantages

CRISPR Interference (CRISPRi) for Gene Suppression

CRISPR-Cpf1

CRISPR: Ethical and Safety Concerns

How Does CRISPR Compare to Other Gene-Editing Techniques?

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

See more featured articles »

Uses of CRISPR/Cas Biosensing Systems

What is CRISPR/Cas9?

Electroporation and the Production of Knockout Mice

Editing Sperm DNA using CRISPR

Latest CRISPR News and Research

AI and CRISPR technologies drive proactive health monitoring

JMIR Publications today featured two new stories in its News and Perspectives section, highlighting a shift toward proactive, tech-integrated health monitoring.

30 Apr 2026

New genetic risk test estimates inherited risk for cardiovascular conditions

Researchers at Mass General Brigham Heart and Vascular Institute and collaborators have developed and validated a new genetic risk test that can estimate a person's inherited risk for eight common cardiovascular conditions, offering a more comprehensive approach to prevention.

29 Apr 2026

Addgene reinforces its expanding role in research with new brand

Addgene, a purpose-driven organization that joins with scientists around the world to reduce barriers to research and foster innovation, today announced that its strategic growth and expanded services have driven the organization’s refreshed brand.

From Addgene 29 Apr 2026

Scientists redesign CAR-T cells to fight more than cancer

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

29 Apr 2026

New human cell model replicates key mechanisms of neurodegenerative diseases

Researchers at LMU have developed a human cell model that replicates key mechanisms of neurodegenerative diseases - with potential for novel therapies.

23 Apr 2026

Common gene in axolotls, mice and zebrafish may unlock human limb regrowth

Investigating a common gene in three very different species – axolotls, mice and zebrafish – scientists have discovered the potential for a novel gene therapy aimed at eventually regrowing limbs in humans, according to new research published this week.

21 Apr 2026

Study creates genetic roadmap of how HIV virus interacts with human cells

The human immunodeficiency virus (HIV), which is the cause of AIDS, is a master of deception, using just nine genes to hijack the complex cellular machinery of the human body.

20 Apr 2026

New study reveals CRISPR enzyme that responds to human DNA methylation

Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells. Now, a team of scientists from Wageningen University & Research and Van Andel Institute has identified a way to exploit this distinction. Using a variant of CRISPR, a modern tool for editing DNA, they distinguished tumor DNA from healthy DNA and selectively cut only the former. The study, published today in Nature, is an early but promising step toward a cancer therapy that targets and destroys tumor cells with high precision.

20 Apr 2026

New research reveals how parasites break out of host cells

Parasites are a major global health problem, underlying many human diseases worldwide. For example, Plasmodium falciparum, the parasite responsible for malaria, plays a well-established; however, its complex life cycle is not yet fully understood.

15 Apr 2026

New CRISPR tool selectively cuts tumor DNA while sparing healthy cells

Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells.

15 Apr 2026

AP-1 proteins help cancer cells rewire genes to survive treatment

A long-standing mystery in cancer treatment is how tumor cells so often become resistant to drugs, even ones they have never encountered before.

15 Apr 2026

New method boosts AI-driven protein engineering with massive data

Protein engineering is a field primed for artificial intelligence research. Each protein is made up of amino acids; to optimize a protein function, researchers modify proteins by switching out one of 20 different amino acids for another.

13 Apr 2026

Targeting super-enhancer mechanisms offers new strategies for cancer therapy

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create "transcriptional addiction" in cancer.

13 Apr 2026

Pseudogene lncRNAs regulate cancer stem cell behavior and signaling

Cancer stem cells (CSCs), a critical subpopulation within tumors, drive cancer initiation, progression, metastasis, relapse, and resistance to therapy due to their innate capacity for self-renewal and differentiation.

11 Apr 2026

Non-clinical safety assessment crucial for CRISPR-based gene therapies

The rapid evolution of CRISPR/Cas genome editing has redefined the possibilities of cellular and gene therapy, enabling precise correction, disruption, and regulation of disease-associated genes.

10 Apr 2026

One letter DNA change switches sex development in mice

Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development in mice.

9 Apr 2026

Gladstone investigator wins MIND Prize to decode hidden Alzheimer’s genetics

Gladstone Institutes investigator Ryan Corces, PhD, has been named a 2026 winner of the Pershing Square Foundation's MIND Prize, a prestigious award recognizing next-frontier thinkers who are uncovering a deeper understanding of the brain and cognition.

7 Apr 2026