CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

CRISPR: Ethical and Safety Concerns

CRISPR and Cas proteins have become a crucial tool for genetic manipulation in biomedical research and biotechnology, and the crux of its action is the recognition of specific sequences in the DNA and their subsequent cleavage from the chain. One specific system, CRISPR-Cas9, has become the standard for genetic editing, since it can be tailored to target any set of DNA sequences. Thus it is of no wonder that it caused an upheaval in biomedical field.

What is CRISPR/Cas9?

CPISPR Applications

CRISPR: The End for Zinc Fingers?

How Does CRISPR Compare to Other Gene-Editing Techniques?

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

Manipulating RNA sequences using CRISPR-Cas13

CRISPR-Cpf1

CRISPR Interference (CRISPRi) for Gene Suppression

Electroporation and the Production of Knockout Mice

CRISPR-Cas14: Discovery, Function, Advantages

Uses of CRISPR/Cas Biosensing Systems

See more featured articles »

Editing Sperm DNA using CRISPR

Latest CRISPR News and Research

UH experts in cloning and stem cell science take the first step toward unraveling cystic fibrosis

Two nationally recognized experts in cloning and stem cell science from the University of Houston are taking the first step toward limiting the consequences of chronic inflammation in cystic fibrosis (CF) by identifying the source of this persistent and enigmatic inflammation in CF lungs.

24 May 2022

Gene-edited tomatoes could be a simple solution to address vitamin D insufficiency

Tomatoes gene-edited to produce vitamin D, the sunshine vitamin, could be a simple and sustainable innovation to address a global health problem.

23 May 2022

Study reveals how ZBP1 could lead to a cytokine storm during COVID-19

Scientists from St. Jude Children's Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell death pathway, PANoptosis, are major contributors to the negative effects of interferon treatment and high interferon levels in some COVID-19 patients.

20 May 2022

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

Northwestern Medicine investigators have discovered a potential therapeutic target for the most common type of pancreatic cancer, according to a study published in Developmental Cell.

19 May 2022

Micro Products with Macro Impact; The Role of Microplate Readers in Life Sciences

In this interview, we speak to Martin Mangold, an applications specialist at BMG LABTECH, about their microplate readers and the essential role they play within life sciences research.

From BMG LABTECH GmbH 19 May 2022

Emerging DNA-based sensors are promising tools for food safety

In a recent study published in the journal TrAC Trends in Analytical Chemistry, researchers discussed the current trends, challenges, and future of the deoxyribonucleic acid (DNA)-based sensors in real-time and rapid food contaminants analysis.

18 May 2022

Why do diabetic patients have more severe SARS-CoV-2 infections?

A recent study published in the journal Cell Metabolism illustrated the function of angiotensin-converting enzyme 2 (ACE2) in renal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among diabetic patients.

16 May 2022

Researchers discover new gene that confers resistance to prostate cancer treatment

Northwestern Medicine investigators have identified a gene that confers resistance to a common prostate cancer treatment, according to a study published in Cancer Research.

13 May 2022

The promise of RNA medicine is targeted and personalized

The development of messenger RNA (mRNA) vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has only increased the impetus in this field.

11 May 2022

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

An article published in the journal Molecular Psychiatry reveals the molecular mechanisms to explain how the YWHAZ gene –related to psychiatric and neurological disorders such as autism and schizophrenia– can alter the neurodevelopmental process.

10 May 2022

bit.bio launches Huntington’s disease human cell model

First neurodegenerative disease model launched from bit.bio's new ioDisease Model portfolio.

From bit.bio 10 May 2022

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

Evaluating the Role of Automated LabTech Instruments within Research

In this interview, we speak to Günter Tenzler, founder and CEO of INHECO, about their automated labtech instruments and their role within scientific research.

From Inheco 9 May 2022

Potential antiviral targets in SARS-CoV-2

Researchers assessed potential targets in severe acute respiratory syndrome coronavirus 2.

6 May 2022

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

A recent study under review at Nature Portfolio and posted to the Research Square* preprint server depicted how cellular nucleic acid-binding protein (CNBP) inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

Study explores SARS-CoV-2 RNA genome's functional interactions with host cell

In a new study, a worldwide map of the SARS-CoV-2 genome-associated host proteins was developed by a team of researchers using the identification of RNA-binding protein by MS (ChIRP-MS) technique.

3 May 2022

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.

2 May 2022

Unraveling how strigoractone hormone regulates massive gene networks controlling plant growth

As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond to the environment and integrate the signals from outside with endogenous developmental programs.

28 Apr 2022

Study offers critical clues into longstanding mystery of deep sleep

Healthy sleep is a basic physiologic need. In its absence, a myriad of processes in the body can go terribly awry. Chronic sleep problems have been linked to mental health disorders, cardiovascular disease, type 2 diabetes, and obesity, among other conditions.

28 Apr 2022

Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

CRISPR

Overview

What is CRISPR/Cas9?

CPISPR Applications

CRISPR: The End for Zinc Fingers?

Feature Articles

How Does CRISPR Compare to Other Gene-Editing Techniques?

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

Manipulating RNA sequences using CRISPR-Cas13

CRISPR-Cpf1

CRISPR Interference (CRISPRi) for Gene Suppression

Electroporation and the Production of Knockout Mice

CRISPR-Cas14: Discovery, Function, Advantages

Uses of CRISPR/Cas Biosensing Systems

Editing Sperm DNA using CRISPR

Latest CRISPR News and Research

UH experts in cloning and stem cell science take the first step toward unraveling cystic fibrosis

Gene-edited tomatoes could be a simple solution to address vitamin D insufficiency

Study reveals how ZBP1 could lead to a cytokine storm during COVID-19

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

Micro Products with Macro Impact; The Role of Microplate Readers in Life Sciences

Emerging DNA-based sensors are promising tools for food safety

Why do diabetic patients have more severe SARS-CoV-2 infections?

Researchers discover new gene that confers resistance to prostate cancer treatment

The promise of RNA medicine is targeted and personalized

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

bit.bio launches Huntington’s disease human cell model

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Evaluating the Role of Automated LabTech Instruments within Research

Potential antiviral targets in SARS-CoV-2

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

Study explores SARS-CoV-2 RNA genome's functional interactions with host cell

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Unraveling how strigoractone hormone regulates massive gene networks controlling plant growth

Study offers critical clues into longstanding mystery of deep sleep

Genetic cause of lupus identified

Using AI to Achieve Earlier Diagnosis of Pancreatic Cancer

Improving Patient Recruitment for Clinical Trial Research

Micro Products with Macro Impact; The Role of Microplate Readers in Life Sciences