Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about CeeNU. It does not contain all the
available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
CeeNU against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What CeeNU is used for
CeeNU is used to treat brain cancer. It may also be used to treat another type of
cancer called Hodgkin's Disease.
CeeNU belongs to a group of medicines called cytotoxic medicines. You may also hear
of these being called chemotherapy medicines.
CeeNU works by killing cancer cells.
CeeNU is often used in combination with other medicines to treat your cancer.
Your doctor may have prescribed CeeNU for another reason. Ask your doctor if you have
any questions about why CeeNU has been prescribed for you.
This medicine is available only with a doctor's prescription.
Safety and effectiveness in children have not been established.
Before you take CeeNU
Do not take CeeNU if you have a severe allergy to CeeNU or any of the ingredients
listed at the end of this leaflet,
Symptoms of an allergic reaction may include:
shortness of breath, wheezing, difficulty breathing or a tight feeling in your chest
swelling of the face, lips, tongue or other parts of the body
rash, itching, hives or flushed, red skin
dizziness or light headedness
Do not take CeeNU if you have, or have had, any of the following medical conditions,
unless you have discussed it with your doctor:
blood disorder with a reduced number of red or white blood cells
lung disease (including asthma)
heart problems (including a heart attack)
any other cancer
lowered immunity due to treatment with medicines such as corticosteroids, cyclosporin
or other medicines used to treat cancer
Tell your doctor if you have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes
Tell your doctor if you have an infection or high temperature.
Your doctor may decide to delay your treatment until the infection has gone. A mild
illness, such as a cold, is not usually a reason to delay treatment.
You should advise your doctor if you have had surgery recently.
Females: tell your doctor or pharmacist if you are pregnant or intend to become pregnant.
Like most cytotoxic medicines, CeeNU is not recommended for use during pregnancy.
If there is any need to consider CeeNU during your pregnancy, your doctor will discuss
with you the benefits and risks of using it. CeeNU may affect your developing baby
if you take it during pregnancy.
Males: tell your doctor or pharmacist if your partner intends to become pregnant while
you are taking CeeNU or shortly after you have stopped taking CeeNU.
You should use some kind of birth control while you are taking CeeNU and for at least
12 weeks after you stop using it.
CeeNU may cause birth defects if either the male or female is using it at the time
Do not breastfeed while taking CeeNU.
CeeNU passes into breast milk and therefore there is a possibility that the breast-fed
baby may be affected.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you buy without a prescription from your pharmacy, supermarket or health food
shop. Some medicines and CeeNU may interfere with each other.
These medicines may be affected by CeeNU, or may affect how well it works. You may
need different amounts of your medicine, or you may need to have different medicines.
Your doctor or pharmacist will advise you.
CeeNU when used in combination with other drugs or radiation therapy may further depress
your immune system. Your doctor or pharmacist may have more information on medicines
to be careful with or avoid while having CeeNU.
If you are not sure whether you should start taking CeeNU or if you have not told
your doctor about any of the above, you MUST tell them before you start taking CeeNU.
How to take CeeNU
Follow all directions given to you by your doctor or pharmacist carefully.
They may differ from the information contained in this leaflet. Your doctor or pharmacist
will tell you how many capsules you will need to take, the time between doses and
the length of time to take CeeNU. This depends on your condition and your weight and
whether or not you are taking any other medicines.
If you do not understand the instructions on the bottle, ask your doctor or pharmacist
How much to take
Your doctor will tell you how many capsules you will need to take, the time between
doses and the length of time to take CeeNU. This depends on your condition and your
weight and whether or not you are taking any other medicines.
How to take it
Swallow CeeNU whole with a full glass of water. Do not chew the capsules.
The capsules have a special coating to stop them dissolving until they have passed
through the stomach into the intestines where they work. Chewing them destroys the
When to take it
Take CeeNU on an empty stomach, for example, 1 hour before food or 2 hours after food.
Food can interfere with the absorption of CeeNU.
How long to take it
Continue taking your medicine for as long as your doctor tells you.
Your doctor will tell you when your treatment should be stopped.
CeeNU is given as a single oral dose. Another dose of CeeNU will not be repeated for
at least six weeks. This is called one cycle of chemotherapy. Your doctor will decide
how many of these cycles you will need.
If you forget to take it
If you have forgotten to take a dose of CeeNU, contact your doctor.
If you take too much (overdose)
Immediately telephone your doctor or pharmacist or the Poisons Information Centre
(telephone 13 11 26), or go to Accident and Emergency at your nearest hospital, if
you think that you or anyone else may have taken too much CeeNU. Do this even if there
are no signs of discomfort or poisoning.
You may need urgent medical attention.
While you are using CeeNU
Things you must do
Be sure to keep all your doctor's appointments so your progress can be checked.
Your doctor may want to check your blood pressure and do some blood and other tests
from time to time to check on your progress and detect any unwanted side effects.
Keep follow up appointments with your doctor.
It is important to have your follow-up doses of CeeNU at the appropriate times to
get the best effects from your treatments.
If you forget a hospital appointment, immediately contact your doctor.
Tell any other doctors, dentists and pharmacists who are treating you that you are
If you are about to be started on any new medicine, tell your doctor, dentist or pharmacist
that you are taking CeeNU.
If you plan to have surgery that needs a general anaesthetic, tell your doctor or
dentist that you are taking CeeNU.
If you become pregnant while taking CeeNU, tell your doctor.
CeeNU can lower the number of white blood cells and platelets in your blood. This
means that you have an increased chance of getting an infection or bleeding. The following
precautions should be taken to reduce your risk of infection or bleeding:
Avoid people who have infections. Check with your doctor immediately if you think
you may be getting an infection, or if you get a fever, chills, cough, hoarse throat,
lower back or side pain or find it painful or difficult to urinate.
Be careful when using a toothbrush, toothpick or dental floss. Your doctor, dentist,
nurse or pharmacist may recommend other ways to clean your teeth and gums. Check with
your doctor before having any dental work.
Be careful not to cut yourself when you are using sharp objects such as a razor or
Avoid contact sports or other situations where you may bruise or get injured.
Things you must not do
Do not give CeeNU to anyone else, even if they have the same condition as you.
Do not take CeeNU to treat any other complaints unless your doctor or pharmacist tells
Do not open the capsules. If a capsule is damaged, avoid contact with your skin and
eyes. If you accidentally touch or inhale the powder, carefully wash the affected
area with water. Avoid inhaling the powder.
Do not drink alcohol while taking CeeNU. You may feel flushed or get headaches.
Do not take more than your doctor has prescribed. High doses of CeeNU may be associated
with a serious blood disorder.
Do not take CeeNU after the expiry date printed on the pack. If you take this medicine
after the expiry date has passed, it may not work as well.
Do not take CeeNU if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
Things to be careful of
Be careful driving or operating machinery until you know how CeeNU affects you.
As with other anticancer medicines, CeeNU may cause nausea, disorientation or tiredness
in some people. Make sure you know how you react to CeeNU before you drive a car,
operate machinery, or do anything else that could be dangerous if you are disorientated
or tired. If this occurs do not drive. If you drink alcohol, disorientation or tiredness
may be worse.
Tell your doctor, nurse or pharmacist as soon as possible if you do not feel well
while you are taking CeeNU. Like other medicines that treat cancer, CeeNU may have
unwanted side effects, some of which may be serious. You may need medical treatment
if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor, nurse or pharmacist if you notice any of the following and they
These are the more common side effects of CeeNU.
nausea, vomiting, loss of appetite, sore mouth
swelling of feet or lower legs
unusual hair loss or hair thinning
feeling tired or drowsy
Tell your doctor or nurse as soon as possible if you notice any of the following.
These may be serious side effects. You may need medical attention.
infections, fever, severe chills, sore throat or mouth ulcers
bleeding or bruising more easily than normal, bleeding gums or nose bleeds, rash
of small reddish-purple spots on your skin), blood in your stool or urine
tiredness, headaches, short of breath when exercising, dizziness, looking pale, fast
shortness of breath or change in breathing, cough, unusual tiredness
passing little or no urine, drowsiness, nausea, vomiting, headache and breathlessness
liver disease with symptoms such as weakness, tiredness, confusion, yellowing of the
eyes and skin, loss of appetite, weight loss and stomach pain
lack of coordination or unsteady when walking, difficulty speaking
Other side effects not listed above may occur in some patients. Tell your doctor,
nurse or pharmacist if you notice anything that is making you fell unwell.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
After using CeeNU
The benefits and side effects of CeeNU may take some time to occur. Therefore even
after you have finished your CeeNU treatment you should tell your doctor immediately
if you notice any of the side effects listed.
Keep your capsules in the bottle until it is time to take them. If you take the tablets
out of the pack they will not keep as well.
Keep your capsules in a cool dry place where the temperature stays below 25°C.
Do not store CeeNU or any other medicine in the bathroom or near a sink.
Do not leave it on a window sill or in the car on hot days. Heat and dampness can
destroy some medicines.
Keep it where children cannot reach it. A locked cupboard at least one-and-a-half
metres above the ground is a good place to store medicine.
What it looks like
Capsule 10 mg: - white, marked CPL3030/10mg
Capsule 40 mg: - white/dark green, marked CPL3031/40mg
Bristol-Myers Squibb Australia Pty Ltd,
4 Nexus Court, Mulgrave,
Victoria 3170, Australia
10 mg capsules AUST R 19252
40 mg capsules AUST R 19249
Date of Preparation: November 2020