Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Pharmorubicin RD.
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of using
Pharmorubicin RD against the benefits it is expected to have for you.
If you have any concerns about this medicine, ask your doctor or pharmacist.
Keep this leaflet.
You may need to read it again.
What Pharmorubicin RD is used for
Pharmorubicin RD is used in the treatment of various types of cancer. It may be used
alone or with other medicines.
Ask your doctor if you have any questions about why Pharmorubicin RD has been prescribed
Your doctor may have prescribed it for another purpose.
Pharmorubicin RD is only available with a doctor's prescription. It is not addictive.
Before you are given Pharmorubicin RD
When you must not be given it
Do not use Pharmorubicin RD if you have ever had an allergic reaction to epirubicin
(the active ingredient in Pharmorubicin RD), other medicines to treat cancer or any
of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty
breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching
or hives on the skin.
Do not use the medicine for injection into a vein if you have:
a low number of red blood cells, white blood cells or platelets in your blood
sore, red mouth from previous treatment or radiation therapy
severe liver problems
heart problems or have ever had heart problems
already received the highest dose allowed for medicines such as mitozantrone, mitomycin
C, doxorubicin or daunorubicin.
Do not use the medicine for injection into the bladder if you have:
cancer that has gone into the bladder wall
kidney or urinary tract infection
swollen or inflamed bladder
problems with a catheter (a tube in your bladder)
blood in the urine.
Do not use Pharmorubicin RD if you are pregnant.
Pharmorubicin RD may harm the unborn child.
Do not use Pharmorubicin RD if you are breastfeeding.
You should not breastfeed while taking Pharmorubicin RD.
Do not use this medicine after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
Before you are given it
You must tell your doctor if you:
have heart problems or have ever had heart problems
have liver problems
have kidney problems
have had radiation therapy previously or are having radiation therapy
have been treated previously with medicines to treat cancer
you are going to be vaccinated (have an injection to prevent a certain disease)
are planning to have children
Pharmorubicin RD may decrease the fertility of men and women.
If you have not told your doctor about any of the above, tell your doctor before you
start using Pharmorubicin RD.
Taking other medicines
Tell your doctor if you are taking any other medicines, including medicines that you
buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines and Pharmorubicin RD may interfere with each other. These include:
medicines used to treatment cancer such as:
other medicines to treat cancer.
medicines used to treat angina or high blood pressure such as:
cimetidine ( a medicine used to treat heartburn or stomach ulcers).
You may need to take different amounts of your medicines or you may need to use different
medicines. Your doctor will advise you.
How Pharmorubicin RD is given
Treatment will normally take place in a hospital. Pharmorubicin RD is usually given
as a slow injection or a drip (infusion) into a vein. It might also be injected into
Do not drink fluids for 12 hours before treatment if Pharmorubicin RD is to be used
in the bladder.
Pharmorubicin RD may be given alone or in combination with other medicines.
Your doctor will decide the dose of Pharmorubicin RD to be given. Treatment is usually
given every 3 to 4 weeks, in cycles of therapy. However, your doctor may give Pharmorubicin
RD more or less frequently.
Treatment will not be repeated until your blood counts have returned to acceptable
levels and any unwanted effects have been controlled.
Your doctor may change your dose during treatment.
Your doctor will let you know how many cycles of treatment you will need.
Ask your doctor if you have any questions about the dose of Pharmorubicin RD and how
it is given.
If you are given too much (overdose)
As Pharmorubicin RD is likely to be given to you in hospital under the supervision
of a doctor, it is unlikely that you will receive too much.
However, immediately tell your doctor or telephone the Poisons Information Centre
on 13 11 26 for advice, or go to Accident and Emergency at your nearest hospital if
you have side effects after being given Pharmorubicin RD.
You may need urgent medical attention.
Symptoms of overdose with Pharmorubicin RD include the side effects below in the 'Side
Effects' section, but they are usually of a more severe nature.
While you are using Pharmorubicin RD
Things you must do
Tell your doctor or nurse immediately if the injection stings or hurts while it is
The injection may need to be stopped and injected into a different vein.
Make sure you follow your doctor's instructions and keep all appointments.
Your doctor will regularly check the function of your heart, liver and kidneys. You
will also need to have blood tests.
Use contraception (birth control) to prevent pregnancy while you or your partner are
being treated with Pharmorubicin RD.
Pharmorubicin RD may cause birth defects if either the male or female is being treated
with Pharmorubicin RD. Men being treated with Pharmorubicin RD must use effective
contraceptive methods during treatment and for at least 3.5 months after treatment.
Women being treated with Pharmorubicin RD must use effective contraceptive methods
during treatment with Pharmorubicin RD and at least 6.5 months after treatment.
Tell your doctor immediately if you become pregnant while taking Pharmorubicin RD.
Tell your doctor if you have an infection or fever.
Pharmorubicin RD lowers your ability to fight infection.
Tell your doctor if you would like to take medicine to prevent or treat nausea (feeling
sick) or vomiting.
Pharmorubicin RD may cause nausea and vomiting,
Tell any doctor, dentist or pharmacist who treats you that you are being treated with
If you are about to be started on any new medicine, tell your doctor and pharmacist
that you are being treated with Pharmorubicin RD.
Things to be careful of
Be careful driving, operating machinery or doing jobs that require you to be alert,
until you know how Pharmorubicin RD affects you.
PHARMORUBICIN RD may make some people feel tired or dizzy.
Tell your doctor as soon as possible if you do not feel well while you are being treated
with Pharmorubicin RD.
All medicines can have unwanted side effects. Sometimes they are serious, most of
the time they are not. You may need medical treatment if you get some of the side
effects. Medicines can affect people in different ways.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
nausea (feeling sick) or vomiting
sore mouth or tongue, mouth ulcers, redness of mouth, sore vagina or rectum
redness of the skin or vein at the site of the injection
hair loss, beard stops growing
dehydration (thirsty, dry mouth, dry skin, loss of body fluid)
sore oesophagus (food pipe), pain on swallowing or difficulty with swallowing
stomach pain or burning feeling in stomach
skin rash, itchy skin, hives, sensitive skin, blisters
change in colour of skin or nails
increased sensitivity to the sun
itchy eye, crusty eyelid, sore red eye, blurred vision, conjunctivitis
loss of appetite
absence of menstrual bleeding (temporary loss of periods)
weakness, tiredness, dizziness, confusion, depression
tingling or numbness of hands or feet; pins and needles
red coloured urine.
Pharmorubicin RD is red and may cause the urine to be a red colour for one or two
days after treatment. There is no cause for alarm.
Tell your doctor immediately if you get any of the following side effects:
stinging, swelling or pain at the site of injection
flushing of face while the injection is being given
an infection or chills, fever, sore throat, swollen glands, shock
heart problems, fast or irregular heartbeat, shortness of breath
swelling of ankles, feet, legs or hands
bleeding or bruising under the skin
cough, difficulty breathing, chest pain, coughing up blood
swelling, pain, tenderness and redness of the leg.
The above side effects may be serious. You may need urgent medical attention.
Tell your doctor if you notice anything else that is making you feel unwell.
Other side effects not listed above, such as leukaemia, may also occur in some patients.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
After using Pharmorubicin RD
Tell your doctor immediately if you notice any of the following side effects, even
if they occur several months or years after stopping treatment with Pharmorubicin
heart problems, fast or irregular heartbeat, shortness of breath
swelling of ankles, feet, legs or hands, swelling in the stomach
fever or other signs of infection.
Leukaemia may occur after treatment with Pharmorubicin RD and other medicines to treat
cancer. It is rare.
This medicine will be stored in the hospital pharmacy and will be looked after by
your doctor or pharmacist.
Pharmorubicin RD should be stored below 25°C.
What it looks like
Pharmorubicin RD is a powder that is dissolved in a solution before injection.
The active ingredient in Pharmorubicin RD is epirubicin hydrochloride. It also contains
lactose and methyl hydroxybenzoate.
Pharmorubicin RD is supplied by:
Pfizer Australia Pty Ltd
Toll Free Number 1800-675 229.
Australian Registration Numbers
50 mg: AUST R 40220.
Date of preparation
This leaflet was revised in May 2021.
© Pfizer Australia Pty Ltd.
® Registered trademark.