Tretinoin 0.05% w/w
Consumer Medicine Information
What is in this leaflet
Read this leaflet carefully before you start RETRIEVE treatment, even if you have
used RETRIEVE before.
This leaflet answers some common questions about RETRIEVE. It does not contain all
the available information. It does not take the place of talking to your doctor or
All medicines have risks and benefits. Your doctor has weighed the risks of you using
RETRIEVE against the benefits this medicine is expected to have for you.
If you have any concerns about using RETRIEVE, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What Retrieve is used for
RETRIEVE is used for the treatment of dry, sun-damaged skin. It contains tretinoin
which is the acid form of Vitamin A. It works by regulating the growth and regeneration
of the outer layer of the skin. This medicine is only available with a doctor's prescription.
Your doctor may have prescribed RETRIEVE for another reason. Ask your doctor if you
have any questions why RETRIEVE has been prescribed for you.
Before you use Retrieve
When you must not use it
Do not use RETRIEVE if you have an allergy to:
any medicine containing tretinoin, isotretinoin or vitamin A.
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
shortness of breath
wheezing or difficulty in breathing
swelling of the face, lips, tongue or other parts of the body
rash, itching or hives on the skin
Do not use this medicine after the expiry date (EXP) printed on the pack.
Do not use this medicine if the packaging is torn or shows signs of tampering. If
it is expired or is damaged, return it to your pharmacist for disposal.
Do not give this medicine to children.
Before you start to use it
Tell your doctor if:
you are pregnant or plan to become pregnant.
you are breast-feeding or wish to breast-feed.
you have sunburn. Delay the use of RETRIEVE until the skin is fully recovered.
you have other forms of skin disease such as eczema.
Delay use of RETRIEVE until the eczema has cleared or use with caution. RETRIEVE
can cause severe irritation on eczema.
you have sensitive skin.
If you have not told your doctor about any of the above, tell him/her before you start
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any
that you get without a prescription from your pharmacy, supermarket or health food
shop, cosmetics or any other skin preparations.
In particular, tell your doctor or pharmacist if you are using any of the following:
Medicines and skin preparations used to treat acne.
Skin preparations containing peeling agents (e.g. resorcinol, sulphur, salicylic acid
or benzoyl peroxide).
Skin preparations containing vitamin A.
Cosmetics, perfumes or astringents (e.g. aftershave, skin toner) especially those
containing high concentration of alcohol, spices, lime, menthol.
Abrasive powders, scrubbing agents, soaps, shampoos or cleansers.
Your doctor or pharmacist can help you avoid products that may cause problems. If
you have forgotten to discuss with your doctor or pharmacist about any of these things,
tell them before you start using RETRIEVE treatment.
How to use Retrieve
When to use it
RETRIEVE is usually used once a day before going to bed.
How much to use
The usual dose is to apply a thin layer to the affected skin area(s).
How to use it
Carefully follow the exact instructions given to you by your doctor or pharmacist.
These may differ from the information contained in this leaflet.
If you are using a new tube, unscrew the cap and check that the aluminium seal is
intact. To break the seal, reverse the cap and pierce through.
Wash the affected areas with a mild soap free cleanser and lukewarm water. Pat dry.
Apply the cream to the affected skin. Massage in gently.
Wash hands thoroughly with water after each application.
Only use RETRIEVE on intact skin. Be careful to avoid contact with your eyes, mouth,
lips, angles of the nose and open wounds. Do not swallow.
The treatment program is to be started slowly. The usual dosage regimen is as follows:
First night - Apply, leave on for 5 minutes, then wash off.
Second night - Apply, leave on for 10 minutes, then wash off.
Third night - Apply, leave on for 30 minutes, then wash off.
Fourth night - Apply, leave on for one hour, then wash off.
Fifth night - Apply, leave on for one and a half hours, then wash off.
Sixth night - Apply, leave on for two hours, then wash off.
If, after a two-hour application, no redness or irritation has developed on the skin
the following day, then the application may be left on overnight and washed off next
If there is redness or irritation, check with your doctor.
Your doctor will observe how your skin responds to treatment, and how well it can
tolerate the medication. If excessive skin reactions occur, your doctor may adjust
the application to alternate nights or temporarily discontinue treatment. Therefore
contact your doctor or pharmacist immediately if you notice any unusual symptoms (such
as a rash) during treatment.
How long to use it
At your next visit, your doctor will see how your skin is responding to treatment.
Do not apply more often, or for a longer time than what your doctor has told you.
Your doctor will decide on the best course of treatment according to your skin condition
and response. This may change from time to time depending on your medical condition.
Ask your doctor or pharmacist on how to apply RETRIEVE if you are not sure.
If you forget to use Retrieve
Apply the medicine when you remember, and then go back to using it as you would normally.
If it is almost time for your next application, skip the dose you missed. Go on to
apply the next dose as before. Do not apply double dose to make up for the one you
missed. If you are not sure what to do, ask your doctor or pharmacist. If you have
trouble remembering when to apply your medicine, ask your pharmacist for some guides.
If you have used too much (overdose)
If you have applied too much RETRIEVE, remove any excess applied. Let your doctor
know in the next visit even if you have not had any signs of skin redness or discomfort.
If your skin develops severe skin irritation, stop the treatment and contact your
If you have swallowed RETRIEVE
Do not take this medicine by mouth.
If you or someone else accidentally swallows some RETRIEVE, immediately telephone
your doctor or the Poisons Information Centre (telephone 13 11 26 in Australia) for
advice, or go to Accident and Emergency at the nearest hospital. Do this even if
there are no signs of discomfort or poisoning. The person who has swallowed RETRIEVE
may need urgent medical attention.
While you are using Retrieve
Things you must do
Follow your doctor's instructions. Tell your doctor if, for any reason, you have
not used your medicine exactly as directed. Otherwise, your doctor may think that
it was not working as it should and change your treatment unnecessarily.
Protect your skin when you are in the sun. If you are outdoors, wear protective clothing
and apply a broad-spectrum 30+ SPF sunscreen. Reapply sunscreen regularly.
Tell your doctor if you become pregnant while you are using RETRIEVE. If you are
about to start taking any new medicine, tell your doctor and pharmacist that you are
using RETRIEVE. Tell any other doctors, dentists and pharmacists who treat you that
you are using this medicine.
Things you must not do
Do not swallow this medicine.
Do not apply to the eyes, around eyelids, mouth, lips, mucosa or angles of the nose.
Do not apply other skin preparations on top of the nightly application of RETRIEVE.
Suitable sunscreens and moisturisers may be used during the day.
Do not apply more often than or longer time than what your doctor told you.
Do not use RETRIEVE to treat any other complaint unless your doctor tells you to
Do not give your medicine to anyone else, even if they have the similar symptoms to
Do not mix RETRIEVE with any other preparations. They may prevent RETRIEVE from working.
Things to be careful of
Avoid exposure of the treated area to excessive sunlight or overuse of a sunlamp because
your skin may be more prone to sunburn while you are having RETRIEVE treatment. Practice
the slip/slop/slap program. If prolonged exposure to sunlight cannot be avoided while
you are using RETRIEVE, use at least a 30+ SPF broad-spectrum sunscreen or wear protective
clothing over the treated areas.
Strong Wind/Dry Air
Other weather extremes such as strong wind or cold dry air may cause skin discomfort.
Apply moisturiser or emollient if this occurs. Check with your doctor or pharmacist
about suitable wind protection if you notice any unusual rash or redness.
Do not use any skin treatments, such as skin peels or medicated dressing on the same
affected areas unless your doctor has told you to.
Check with your doctor or pharmacist which cosmetics or perfumed toiletries you can
use. Wash off any cosmetics before you apply RETRIEVE.
Washing your face
Avoid using harsh soaps or exfoliants. Use a mild bland soap, or any suitable soap
RETRIEVE is generally well tolerated. However, like other medicines, RETRIEVE can
cause side effects. If they occur, they are most likely to be minor or temporary.
However, sometimes they are serious and would need medical attention.
Ask your doctor or pharmacist if you have any problems while you are using RETRIEVE.
You may need medical attention if you get some of the side effects.
Tell your doctor if you notice any of the following and they continue to worry you:
redness of skin
feeling of warmth on skin
peeling of skin
darkening or lightening of the treated areas
Tell your doctor immediately if you experience any of the following as you may need
urgent medical care:
the skin becomes very sensitive to light
STOP using RETRIEVE and tell your doctor immediately or go to Accident and Emergency
at your nearest hospital if you have an allergic reaction.
Other side effects not listed above may occur in some patients. Tell your doctor
or pharmacist if you notice any other side effects from your medicine which is making
you feel unwell.
This medicine does not affect your ability to drive or operate machinery.
After using Retrieve
Keep RETRIEVE in a cool dry place where the temperature is below 25°C. Do not leave
this medicine on window sill or inside a freezer. Do not leave this medicine in the
car on hot days. Keep this medicine where children cannot reach it.
Return any unused or expired medicine to your pharmacist, or ask them how to dispose
of it. Do not keep any outdated medicine, or medicine no longer needed. Keep any
discarded medicine out of the reach of children or pets.
What it looks like
RETRIEVE CREAM is a smooth off-white to pale yellow cream contained in a metal tube
with an outer carton and is available in the following pack sizes:
- 5g tube
- 50g tube
RETRIEVE contains 500 microgram per gram of tretinoin as the active ingredient. It
methyl and propyl hydroxybenzoates
propylene glycol and water.
iNova Pharmaceuticals (Australia) Pty Limited
ABN: 13 617 871 539
Level 10, 12 Help Street
Chatswood NSW 2067
Tel: 1800 630 056
®= Registered Trademark
AUST R 15553
The leaflet was prepared in January 1999 and revised November 2017.