Fermentation and cell culture processes are constantly changing, making timely insight into cellular activity essential for maintaining process performance and product quality. This eBook explores how continuous respiratory gas analysis provides a real-time, non-invasive view of cell metabolism, helping overcome the delays and limitations of traditional offline sampling.
Download the full eBook here
Discover how monitoring oxygen consumption and carbon dioxide production can reveal changes in culture health, growth, substrate utilization, and overall process performance. The guide explains key measurements, including Oxygen Uptake Rate (OUR), Carbon Dioxide Evolution Rate (CER), and Respiratory Quotient (RQ), and shows how these insights can help identify metabolic shifts, nutrient depletion, process deviations, and opportunities to optimize feeding strategies.
From early-stage R&D and process characterization through pilot-scale studies and commercial manufacturing, the eBook demonstrates how respiratory gas analysis can support greater process understanding, consistency, and control.
Download the guide to explore how real-time off-gas monitoring can support bioprocess optimization and Process Analytical Technology (PAT) initiatives throughout the development and production lifecycle.
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About Thermo Fisher Scientific – Environmental and Process Monitoring Instruments
We design and manufacture industry-leading products for gas and particulate pollutants, flow, gas and liquid measurement, process analytical measurements, and industrial hygiene.
Technologies have proven to help customers improve efficiency, ensure process and quality control, maintain regulatory compliance, and increase worker safety.
Process mass spectrometers
Maximize product yield and increase profitability with process mass spectrometry analysis. Process gas analyzers are engineered to meet a number of challenging process applications in the petrochemical, iron and steel, and biotechnology industries. Highly reliable and easy-to-own, Thermo Fisher Scientific process gas analysis technologies deliver faster, more complete, lab-quality online gas analysis and process analytics. Learn More
Process Analytical Technology/Biopharma
Process Analytical Technology (PAT) is a regulatory framework initiated by the United States’ Food and Drug Administration (FDA) that encourages pharmaceutical manufacturers to improve the process of pharmaceutical development, manufacturing, and quality control.
PAT aims to improve process efficiency by defining Critical Process Parameters (CPP) and monitoring these CPPs to stay within a defined limit, either in-line or on-line, to maintain a product’s Critical Quality Attributes (CQA). Monitoring CPPs with process mass spectrometry gas analysis reduces over-processing, pinpoints contaminants, and increases product consistency. Learn More
Industrial hygiene
Industrial hygiene instruments keep your investments secure, your facilities compliant with local regulations, and your workers safe from leaking pollutants, gases, or toxic vapors. Make sure you have the most updated technology, with access to repair and calibration support to maintain reliable gas monitoring. With our environmental expertise, you can breathe easy knowing your company, workers, and neighboring communities have cleaner, safer, and healthier air quality. Learn More
Sulfur analyzers
Online sulfur analyzers replace expensive and time-consuming laboratory sampling. Get fast responses and wide measurement ranges of trace sulfur and total sulfur in flare gas, liquid, and vapor for reliable emissions monitoring. Learn More
Gas & particulate analyzers
Increasingly stringent regulatory requirements are making it more difficult to maintain regulatory compliance and optimal process performance. Air quality monitoring and reporting requirements in the U.S., China, India, Europe, and Latin America are shifting and being redefined. Together we can arrive at solutions that make sound business sense. Learn More
Flow measurement
Flow measurement and process control are critical aspects of producing, handling, and transporting hydrocarbons around the world. With our Thermo Scientific suite of flow computers and flow meters, we enable our customers to reduce cost, decrease lost material, automate, and monitor critical points in processes. From field to control room and upstream to downstream, our products provide greater control, confidence, and reliability. Learn More
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