What are Fibroblasts?

NewsGuard 100/100 Score

Fibroblasts are cells found commonly in the body of humans and other animals, which regulate and maintain connective tissue through the production of fibrous proteins and ground substance.


Image Credit: DrimaFilm/Shutterstock.com

Maintenance of connective tissue

The fibrous proteins and ground substance produced by fibroblasts are what constitute the extracellular matrix (ECM), which makes up the bulk of connective tissue.

The ECM has many roles within tissues. Primarily it provides an elastic structural base for tissue growth to help tissues and organs develop, but it also stores growth factors for when they are needed, transmits mechanical signals within the tissue, and acts as an adhesive substrate.

The fibrous proteins produced by fibroblasts mainly consist of fibrin, fibronectin, and collagen. Fibrin and fibronectin provide a basic framework for cells to stick together and form a tissue, whilst collagen provides the mechanical strength needed for the tissue strength.

Ground substance is simply everything else found within the ECM besides fibrous proteins. It is a transparent gel that fills all gaps between cells and helps the tissue resist compression.

The most common constituent of ground substance is glycosoaminoglycans, which are long, unbranched polysaccharide chains. Proteoglycan is an example of a glycosoaminoglycan, which also has various roles in growth factor propagation and enzyme regulation.

Tissue repair

When tissue becomes damaged, nearby fibroblasts within the connective tissue will migrate to this area and secrete a substance that helps to repair the damage.

This substance is a collagenous matrix, meaning it contains high concentrations of collagen, the main structural protein in the body that boosts the repair of cells and tissues.

Fibroblasts can also change into myofibroblasts when stimulated by a wound, which pulls together the extracellular matrix and helps to close the wound to prevent bleeding.

The ability of fibroblasts to survive in damaged tissues, as well as their growth rate even when isolated, are good reasons why fibroblasts are often grown in culture for studies of cells and tissues.

Fibroblast growth factors

Fibroblast growth factors (FGFs) are a type of polypeptide growth factor that is involved in the repair of damaged tissues such as skin, muscle, nervous tissue, and blood vessels. The first role of FGFs that was identified was that they induce the proliferation of fibroblasts within the damaged tissue.

They now have many more known functions including the promotion of the proliferation of other cell types, such as certain stem cells and bone cells, as well as the migration and differentiation of epithelial cells into cells that also promote tissue repair.

Fibroblasts and cell studies

Fibroblasts are easy to maintain in vitro, and fibroblast cell lines can be easily set up to create viable cell models for the study of diseases. This means they are a very good choice in research for various applications in cell studies.

Certain fibroblasts isolated from skin tissue can also be used to create induced pluripotent stem cells (iPSCs). These cells are invaluable in research as they can be used to create many different other types of cells and are a more ethical way of acquiring stem cells without the need for embryonic stem cells (though embryonic stem cells can create a wider array of cells).


If fibroblasts become unregulated they can over-produce the collagenous matrix, which leads to the formation of scar tissue. Whilst this is sometimes useful to seal wounds, too much scar tissue leads to a condition called fibrosis.

Fibrosis has a role in any different diseases, including cystic fibrosis, kidney fibrosis, and cardiac fibrosis.

These conditions are all related to the build-up of thick scar tissue within certain organs, which impairs their function. Maintenance of fibroblasts is therefore vital for the health of organs and tissues.


Further Reading

Last Updated: Mar 26, 2020

Written by

Jack Davis

Jack is a freelance scientific writer with research experience in molecular biology, genetics, human anatomy and physiology, and advanced analytical chemistry. He is also highly knowledgeable about DNA technology, drug analysis, human disease, and biotechnology.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Davis, Jack. (2020, March 26). What are Fibroblasts?. News-Medical. Retrieved on May 23, 2024 from https://www.news-medical.net/life-sciences/What-are-Fibroblasts.aspx.

  • MLA

    Davis, Jack. "What are Fibroblasts?". News-Medical. 23 May 2024. <https://www.news-medical.net/life-sciences/What-are-Fibroblasts.aspx>.

  • Chicago

    Davis, Jack. "What are Fibroblasts?". News-Medical. https://www.news-medical.net/life-sciences/What-are-Fibroblasts.aspx. (accessed May 23, 2024).

  • Harvard

    Davis, Jack. 2020. What are Fibroblasts?. News-Medical, viewed 23 May 2024, https://www.news-medical.net/life-sciences/What-are-Fibroblasts.aspx.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Research demonstrates a bat species' resistance to cancer, pinpoints key genes