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Researchers discover tolerance mechanism in chronic morphine treatment

Researchers from Mount Sinai School of Medicine have discovered a major mechanism underlying the development of tolerance to chronic morphine treatment. The discovery may help researchers find new therapies to treat chronic pain, and reduce tolerance and side effects associated with morphine use. The findings are published in the July 20th issue of Science Signaling.

8 Sep 2010

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they slow tumor growth. Now, researchers in the Developmental Therapeutics Program at Fox Chase Cancer Center have identified an activation signal for AurA. They report in the September 7 issue of Nature Communications that a quick increase in the calcium concentration in a cell rapidly triggers AurA kinase activity.

8 Sep 2010

GW Cancer Institute receives grant to establish City-wide Patient Navigation Network in Washington

The GW Cancer Institute (GWCI) was recently awarded a $2.4 million grant from the D.C. Cancer Consortium to establish and coordinate a City-wide Patient Navigation Network (CPNN) in Washington, D.C.

8 Sep 2010

Few health insurance options for people with pre-existing conditions

The Los Angeles Times: "For people with preexisting medical conditions, looking for health insurance in the private market may feel like the ultimate fool's errand. … When the health reform law takes full effect in 2014, insurers will no longer be able to deny coverage to people with preexisting medical conditions. In the meantime, new federally funded high-risk pools for the medically uninsurable have been established. To qualify, you have to be without insurance for six months.

8 Sep 2010

K-State University receives patent for procedures to source stem cells from umbilical cord

Kansas State University has been a issued a patent for a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord.

8 Sep 2010

Forest Laboratories' ceftaroline fosamil receives FDA Advisory Committee approval for CABP and cSSSI

Forest Laboratories, Inc. announced that the U.S. Food and Drug Administration's (FDA) Anti-Infective Drugs Advisory Committee voted 21 - 0 in favor of approval of ceftaroline fosamil for the treatment of community acquired bacterial pneumonia (CABP) and voted 18 - 0 in favor of approval for complicated skin and skin structure infections (cSSSI).

8 Sep 2010

Fluctuation in PCV-7 vaccine dosing time increases pneumococcal serotype 19A strains: Study

Infants who received heptavalent pneumococcal conjugate vaccination (PCV-7) at 2, 4, and 11 months were more likely than unvaccinated controls to have nasopharyngeal (in the nasal passages and upper part of the throat behind the nose) acquisition of pneumococcal serotype 19A, a leading cause of respiratory pneumococcal disease, according to a study in the September 8 issue of JAMA.

8 Sep 2010

Decreasing pituitary's sensitivity to insulin could be new target for infertility treatment

Obese women have a well-known risk for infertility, but a new Johns Hopkins Children's Center study has unraveled what investigators there believe is the mechanism that accounts for the risk.

8 Sep 2010

Mylan completes acquisition of Bioniche Pharma

Mylan Inc. today announced it has completed the acquisition of Bioniche Pharma Holdings Limited sooner than anticipated.

8 Sep 2010

Local efforts seek to reduce childhood obesity; Sleep-deprived kids most vulnerable

NPR: "[A] new study finds that even for infants and preschoolers, a good, long night's sleep may be just as important as diet and physical activity. Over the past three decades, obesity rates have doubled among children age 2 to 5, and tripled among 6- to 11-year-olds. So University of Washington maternal and child health researcher Janice Bell wanted to know whether sleep had anything to do with it.

8 Sep 2010

Medco Health Solutions agrees to sell two senior notes

Medco Health Solutions, Inc. announced today that it has agreed to sell $500 million aggregate principal amount of 2.750% senior notes due September 15, 2015 and $500 million aggregate principal amount of 4.125% senior notes due September 15, 2020 in an underwritten public offering.

8 Sep 2010

PTSD and traumatic brain injury common among returning troops

NPR reports on post-traumatic stress disorder and traumatic brain injury in troops returning from the wars in Iraq and Afghanistan. "Though thousands of soldiers are diagnosed with PTSD, many more suffer without treatment. Among those who do seek treatment, doctors are finding another, distinctly different problem called traumatic brain injury, or TBI.

8 Sep 2010

Carestream Health acquires Quantum Medical Imaging to enhance x-ray system

Carestream Health has acquired Quantum Medical Imaging, LLC, a privately held manufacturer of high quality digital and conventional x-ray systems used by hospitals, imaging centers and health clinics.

8 Sep 2010

NIH awards St. Jude $8.6M to focus on anticancer agent research in children

With its new expansion of the Pharmacogenomics Research Network (PGRN), the National Institutes of Health (NIH) awarded St. Jude Children's Research Hospital a prestigious grant to focus on anticancer agent research in children.

8 Sep 2010

BMJ investigation raises concern on rosiglitazone diabetes drug safety

A BMJ investigation into the top-selling diabetes drug rosiglitazone (Avandia) raises concerns about its safety and the whole system by which drugs are evaluated, regulated, and promoted around the world.

8 Sep 2010

Small businesses continue to gauge health law implications

Some small business owners remain wary of a health law they do not yet clearly understand, The Kansas City Star reports. "Employers with 50 or more employees know this: The new law has employee coverage mandates looming for them in 2014. Employers with fewer than 50 employees will escape the coverage mandate. But they're not resting easy." Business expect costs to increase by between 6 and 40 percent in 2011, and many wonder whether they will be able to continue to afford subsidizing their employees' insurance coverage (Stafford, 9/6).

8 Sep 2010

DTC consumers express concern on personal genetic risk test

One half of people using direct to consumer (DTC) personal genetic risk tests express concerns about testing yet more than 80 percent want to know their risk even for non preventable genetic diseases, according to a study in the September Genetics in Medicine, the official peer reviewed journal of The American College of Medical Genetics (ACMG).

8 Sep 2010

Obesity directly accelerates progression of acute lymphoblastic leukemia

The first study to demonstrate that obesity can directly accelerate the progression of acute lymphoblastic leukemia (ALL) has been conducted at The Saban Research Institute of Childrens Hospital Los Angeles and will be published in Cancer Prevention Research, on October 5, 2010. Obesity has been associated with an increased incidence of many cancers, including leukemia, but it has been unknown whether the increase in incidence was a direct effect of obesity or associated with genetic, lifestyle, health, or socio-economic factors.

8 Sep 2010

HHS issues guidance on waivers for health plan limits

The Hill: "The Department of Health and Human Services has released guidance for health plans seeking a waiver from the healthcare reform law's restrictions on plans' ability to place annual limits on essential health benefits.

8 Sep 2010

Interventions targeting social cognition most effective in mitigating loneliness

Changing how a person perceives and thinks about others was the most effective intervention for loneliness, a sweeping analysis of previous research has determined. The findings may help physicians and psychologists develop better treatments for loneliness, a known risk factor for heart disease and other health problems.

8 Sep 2010

Medical News

Researchers discover tolerance mechanism in chronic morphine treatment

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

GW Cancer Institute receives grant to establish City-wide Patient Navigation Network in Washington

Few health insurance options for people with pre-existing conditions

K-State University receives patent for procedures to source stem cells from umbilical cord

Forest Laboratories' ceftaroline fosamil receives FDA Advisory Committee approval for CABP and cSSSI

Fluctuation in PCV-7 vaccine dosing time increases pneumococcal serotype 19A strains: Study

Decreasing pituitary's sensitivity to insulin could be new target for infertility treatment

Mylan completes acquisition of Bioniche Pharma

Local efforts seek to reduce childhood obesity; Sleep-deprived kids most vulnerable

Medco Health Solutions agrees to sell two senior notes

PTSD and traumatic brain injury common among returning troops

Carestream Health acquires Quantum Medical Imaging to enhance x-ray system

NIH awards St. Jude $8.6M to focus on anticancer agent research in children

BMJ investigation raises concern on rosiglitazone diabetes drug safety

Small businesses continue to gauge health law implications

DTC consumers express concern on personal genetic risk test

Obesity directly accelerates progression of acute lymphoblastic leukemia

HHS issues guidance on waivers for health plan limits

Interventions targeting social cognition most effective in mitigating loneliness

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

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