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Obese type 2 diabetics carry mitochondrial proteins that reduce response to physical exercise

Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A study at the Institute for Research in Biomedicine and Trinity College in Dublin demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise.

15 Mar 2010

Keystone Symposia receives NIH grant for diversity initiatives

Keystone Symposia on Molecular and Cellular Biology is pleased to announce receipt of a $1.37 million, five-year MARC (Minority Access to Research Careers) Ancillary Training Activities grant from the National Institute of General Medical Sciences of the National Institutes of Health (NIH).

15 Mar 2010

Medafor, Magle Life Sciences of Sweden sign long-term raw material supply agreement

Medafor Inc. announced today that it has signed a long-term raw material supply agreement with Magle Life Sciences of Sweden, the supplier of the key powder component for Medafor’s patented MPH(R) (Microporous Polysaccharide Hemosphere) surgical product, which is used by surgeons to control bleeding in complex surgical operations.

15 Mar 2010

Ligand Pharmaceuticals: GSK granted marketing authorization from EC for Revolade

Ligand Pharmaceuticals Incorporated today announced that GlaxoSmithKline was granted marketing authorization from the European Commission for Revolade® (eltrombopag) for the oral treatment of thrombocytopenia (reduced platelet count) in adults with the blood disorder chronic immune (idiopathic) thrombocytopenic purpura (ITP).

15 Mar 2010

Health bill update: Pelosi counting votes, Scott Brown lambastes Dems

News outlets reported that Democrats seeking to pass a health bill next week got a boost from a Cabinet official, a key senator and the Catholic Health Association, while newly-elected Sen. Scott Brown, R-Mass., attacked the Democrats' plans.

15 Mar 2010

Two controlled environmental variables to preclinical mice tests can reduce costly false positives: Study

For decades, the traditional practice in animal testing has been standardization, but a study involving Purdue University has shown that adding as few as two controlled environmental variables to preclinical mice tests can greatly reduce costly false positives, the number of animals needed for testing and the cost of pharmaceutical trials.

15 Mar 2010

New study finds green tea extract may prevent Alzheimer's disease and dementia

Long known to be beneficial in heart disease, diabetes and some cancers, a new study finds a specific green tea extract may delay or prevent Alzheimer's disease and dementia. A. Holliday & Company's "Teawell 50," is a 50 percent pure extraction of EGCG (epigallocatechin gallate) – a flavonoid which is the most potent of four major catechins in green tea.

15 Mar 2010

New hydrosurgery system may help manage excessive bleeding during surgery

Carnegie Mellon University's Matt Oberdier is developing a new hydrosurgery system to help physicians better manage excessive bleeding during surgery.

15 Mar 2010

Discovery of MiR-451 molecule may serve as a biomarker for brain tumor

Cancer cells in rapidly growing brain tumors must adjust to periods of low energy or die. When energy levels are high, tumor cells grow and proliferate. When levels are low, the cells grow less and migrate more.

15 Mar 2010

GAVI Alliance reaches agreement with drugmakers on reduced-price pneumococcal vaccines

Several drugmakers have reached an agreement "to supply up to 200 million doses a year of cut-price pneumococcal vaccines to developing nations," according to GAVI Alliance, Reuters reports.

15 Mar 2010

Bio-Path Holdings' liposomal Grb-2 IND receives FDA clearance to proceed into clinical trials

Bio-Path Holdings, Inc., a publicly traded biotechnology company with drug development operations in Houston, Texas, announced today that the U.S. Food and Drug Administration has allowed an IND (Investigational New Drug) for the Company’s lead cancer drug candidate liposomal Grb-2 to proceed into clinical trials.

15 Mar 2010

Brain Science Institute, Eisai sign licensing agreement to develop GCPII inhibitors

Johns Hopkins University's newly formed Brain Science Institute's NeuroTranslational Program has entered into a licensing agreement with pharmaceutical company Eisai Inc. to discover and develop small molecule glutamate carboxypeptidase II (GCPII) inhibitors.

15 Mar 2010

Study finds implant durability not affected by high-impact sports participation

Total knee arthroplasty (TKA) patients may be able to participate in high-impact sports without increasing risk of early implant failure, according to a new study presented today at the 2010 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS).

15 Mar 2010

FDA warns patients and physicians about the efficacy of Plavix treatment

The U.S. Food and Drug Administration today added a boxed warning to the anti-blood clotting drug Plavix (clopidogrel), alerting patients and health care professionals that the drug can be less effective in people who cannot metabolize the drug to convert it to its active form.

15 Mar 2010

ACCORD Lipid trial: New research into atherogenic dyslipidemia in type 2 diabetes

Cardiovascular risk can be reduced by an additional 31 percent in type 2 diabetes patients with atherogenic dyslipidemia, the common combination of elevated triglycerides (TG, 204 mg/dL or 2.3 mmol/L or higher) and low levels of high-density lipoprotein cholesterol (HDL-C, 34 mg/dL or 0.88 mmol/L or lower).

15 Mar 2010

Prioritizing end of life care for cancer patients

Despite the advances and groundbreaking research being performed in the area of cancer treatment, sometimes cancer cannot be cured. In this situation, patients and their families are faced with complex emotions and a variety of end of life issues and decisions.

15 Mar 2010

Confident Democrats predict House passes health bill this week

"Top aides to President Obama hit the Sunday talk shows to proclaim that by the time they air again, the U.S. House will have signed off on major health care legislation. 'I believe it is going to happen this week,' said White House political adviser David Axelrod, speaking on ABC's This Week. 'I think we're going to have a vote'" (Jackson, 3/14).

15 Mar 2010

Zimmer Holdings showcases Continuum Acetabular Cup System at AAOS 2010

Zimmer Holdings, Inc., a leader in musculoskeletal care, today showcased its recently introduced Continuum Acetabular Cup System at the American Academy of Orthopaedic Surgeons (AAOS) annual meeting. The Continuum Cup combines the best of Zimmer's proven hip technologies – Trabecular Metal™ Technology, Metasul® Metal-on-Metal technology, BIOLOX® delta and Longevity® Highly Crosslinked Polyethylene – with new innovations in what is now the company's most versatile acetabular cup system.

12 Mar 2010

MiddleBrook Pharmaceuticals full-year 2009 revenues rise 67.7%

MiddleBrook Pharmaceuticals, Inc. today announced its 2009 fourth quarter and full-year results, that it is further restructuring to reduce expenses, and that it is evaluating strategic alternatives to maximize shareholder value.

12 Mar 2010

Medicare to cover OVA1 test

Vermillion, Inc. today announced that Medicare will cover OVA1™, a test to help assess the likelihood that an ovarian mass is benign or malignant. Highmark Medicare Services is the CMS contractor that will process Medicare claims for OVA1. Yesterday Highmark announced its decision to cover this new service.

12 Mar 2010

Medical News

Obese type 2 diabetics carry mitochondrial proteins that reduce response to physical exercise

Keystone Symposia receives NIH grant for diversity initiatives

Medafor, Magle Life Sciences of Sweden sign long-term raw material supply agreement

Ligand Pharmaceuticals: GSK granted marketing authorization from EC for Revolade

Health bill update: Pelosi counting votes, Scott Brown lambastes Dems

Two controlled environmental variables to preclinical mice tests can reduce costly false positives: Study

New study finds green tea extract may prevent Alzheimer's disease and dementia

New hydrosurgery system may help manage excessive bleeding during surgery

Discovery of MiR-451 molecule may serve as a biomarker for brain tumor

GAVI Alliance reaches agreement with drugmakers on reduced-price pneumococcal vaccines

Bio-Path Holdings' liposomal Grb-2 IND receives FDA clearance to proceed into clinical trials

Brain Science Institute, Eisai sign licensing agreement to develop GCPII inhibitors

Study finds implant durability not affected by high-impact sports participation

FDA warns patients and physicians about the efficacy of Plavix treatment

ACCORD Lipid trial: New research into atherogenic dyslipidemia in type 2 diabetes

Prioritizing end of life care for cancer patients

Confident Democrats predict House passes health bill this week

Zimmer Holdings showcases Continuum Acetabular Cup System at AAOS 2010

MiddleBrook Pharmaceuticals full-year 2009 revenues rise 67.7%

Medicare to cover OVA1 test

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