Why metabolite identification is critical for early-stage drug design

This episode of the Pharmaron DMPK Insights Podcast Series sees Dan Weston (Scientific Leader of Biotransformation at GSK) provide insight into his recent publication on the importance of Metabolite ID in drug discovery.

The episode discusses a range of relevant topics, including:

• The importance of studying biotransformation as part of early drug design
• Optimizing data delivery and quality via a combination of high-resolution MS, in silico tools, and software-assisted data analysis
• How Metabolite ID influences medicinal chemistry and the design–make–test cycle

Watch Full Podcast Here

References and further reading

1. Weston, D.J., et al. (2022). A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism. Xenobiotica, 52(8), pp.928–942. DOI: 10.1080/00498254.2022.2136042. https://www.tandfonline.com/doi/abs/10.1080/00498254.2022.2136042.

Acknowledgments

Produced from materials originally authored by Pharmaron Beijing Co., Ltd.

About Pharmaron

Pharmaron (Stock Code: 300759.SZ/3759.HK) is a premier R&D service provider for the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities, and established a broad spectrum of research, development and manufacturing service capabilities throughout the entire drug discovery, preclinical and clinical development process across multiple therapeutic modalities, including small molecules, biologics and CGT products. With over 17,000 employees, and operations in China, the U.S., and the U.K., Pharmaron has an excellent track record in the delivery of R&D solutions to its partners in North America, Europe, Japan and China.

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