The principles of macrocyclic drug discovery

This on-demand webinar, hosted by Pharmaron, will explore the growing use of macrocycles in drug design and discovery, focusing on the principles behind their rational design and examining both the advantages and challenges of working with this unique class of compounds.

What will the webinar cover?

• An introduction to macrocycles
• What are macrocyclic drugs?
• What are their advantages compared to their acyclic counterparts?
• An overview of macrocycle rational design
• What strategies are used to design effective macrocycles?
• What are the key principles for optimizing their physicochemical properties?
• Case Study: The Discovery of a novel series of PKCθ inhibitors with exceptional potency and isoform selectivity
• Key successes and challenges faced during lead optimization

About the speakers

• Mike Waring – Professor, Newcastle University, Chair of Medicinal Chemistry
• Sébastien Campos, Ph.D.​ – Senior Director, Medicinal Chemistry at Pharmaron
• Moderated by Kevin Foote, Ph.D. – VP of Drug Discovery at Pharmaron