Stem cells are particularly interesting for researchers as they are initially undifferentiated and differentiate into specialized cells over time. In recent years, significant research has been carried out on stem cells to explore how they can aid in therapeutics. Using a particle shape and size analyzer can help with this process.
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Particle characterization of stem cells
The Particle Insight analyzer quantifies cells by shape and size, and has been used for stem cell analysis using dynamic image analysis. This high-speed analyzer quantifies and differentiates between identified particles: for example, the stem cells themselves, and any debris that is suspended in the fluid.
A critical aspect of this application is measuring concentration, which allows for the accurate differentiation of cells and debris. Knowing the concentration of each identified population in the sample is also important for understanding its composition.
Stem Cell Size and Shape Application Vision Analytical
Video Credit: Vision Analytical Inc.
The importance of shape analysis
The particle shape and size analyzer can capture images of particles, providing objective evidence for each sample. It is crucial to investigate the size and opacity of stem cells when measuring their viability. Considering other parameters, such as concentration and circularity, is also important.
Why choose dynamic imaging for size and shape analysis
Concentration, shape, and size are useful pieces of information when researching stem cell science. The Particle Insight analyzer has been used to investigate stem cells and their elongation as they move toward apoptosis.
Particle shape and size analyzers, including the Particle Insight, quantify and calculate data in real time and store data, including thumbnail images. These images provide a visual presentation that enhances understanding of the suspended particles.
Benefits offered by the insight series of products
Vision Analytical’s Particle Insight particle shape and size analyzer is capable of enumeration. This means it can be used to determine both the concentration and the percentage of small or dark particles in the entire population.
Software tools can be used alongside the Particle Insight to acquire more in-depth information. This information can subsequently be used to correlate a cell’s opacity with its size. The correlation function could also be used to ascertain whether particles get rougher as they increase in size, and many other characteristics.
This particle classification function enables the user to gain a deeper analysis of sub-populations within the sample. These particles can be categorized into different classes based on their shapes. This, in turn, can help identify the percentage of each population present in the sample.
About Vision Analytical Inc.
Vision Analytical is an established company focused on Particle Size, Count, Shape, Concentration, and Classification using Dynamic Image Analysis. Our mission is to create superior, customer-focused solutions and services to deliver tangible economic impact through physical analysis of raw materials using image analysis of particles. Our product line of instruments helps users better understand a wide variety of materials in a broad spectrum of industries, from industrial to life science industries.
Our core technology, Dynamic Image Analysis, allows for more details to be obtained from raw materials than just size. This robust characterization method allows for a better understanding of how particles will behave, concentration analysis, and other properties not available in size-only instruments.
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