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Study investigates the mechanism underlying kidney damage in COVID-19 patients

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients.

29 Sep 2021

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Buck Institute professors Judith Campisi, PhD and Lisa Ellerby PhD, have been awarded a $14.3 million grant from the NIH's National Institute of Aging to study cellular senescence, one of the major hallmarks of aging, as a driver of Alzheimer's disease and other age-related dementias.

29 Sep 2021

Understanding noise-related hearing loss through changes in RNA levels

A growing number of people are suffering from hearing loss due to exposure to loud noises from heavy machinery, concerts, or explosions.

29 Sep 2021

Long-held theory of cancer-induced immune suppression requires revision, study says

Many cancers produce an enzyme called IDO that suppresses immune system activity, but the long-held hypothesis of how this mechanism operates requires revision, according to a study published in Clinical Cancer Research.

29 Sep 2021

Large-scale SARS-CoV-2 spike protein mutants analysis identifies subclonal variants indicative of within-host viral diversity

Researchers have investigated a vast SARS-CoV-2 assembly and NGS data set to detect non-synonymous S protein mutations.

29 Sep 2021

Scientists link insulin resistance to increased risk of developing major depressive disorder

Stanford Medicine scientists have linked insulin resistance to an increased risk of developing a major depressive disorder.

29 Sep 2021

Study finds correlation between neutralizing antibody titer and reported vaccine efficacy

An observational study compares immune responses against three vaccines.

29 Sep 2021

Vaccine-induced SARS-CoV2 immune responses decline at similar rates as those after infection, study finds

A new preprint describes the causal role of waning antibody titers in decreased antibody persistence at one year.

29 Sep 2021

Novel strategy for in vitro cell-selective protection has potential for use in adoptive cell therapy

Adoptive cell therapy (ACT) is an emerging powerful cancerimmunotherapy, which includes a complex process of genetic modification, stimulation and expansion. During invitroorexvivomanipulation, sensitive cells are inescapably subjected to harmful external stimuli. Although a variety ofcytoprotectionstrategies have been developed, their application on ACT remains challenging.

29 Sep 2021

Two proteins joined together using a free-standing, rigid link

Researchers at the Paul Scherrer Institute PSI are the first to have joined two proteins together by means of a free-standing, rigid link. The structural element holds the two protein molecules together at a defined distance and angle, much the way a barbell handle connects two weights.

29 Sep 2021

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the motor cortex. TDP-43 is a protein that tends to accumulate in increasing amounts, and the amount is strictly controlled by the splicing of TDP-43. Through cell experiments and analysis of human brain tissue, researchers at Brain Research Institute, Niigata University, led by Akihiro Sugai, M.D., Ph.D., have found that methylation of TDP-43 DNA is involved in the background of motor cortex involvement with aging in ALS

29 Sep 2021

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

29 Sep 2021

Duke neurobiologists show how the rigors of natural selection and evolution have shaped the retinas

If you wanted to design the most perfect, low-energy, light-detecting device for a future camera or a prosthetic retina, you'd reach for something called 'efficient coding theory,' to set out the array of sensors.

29 Sep 2021

Aging may not be due to build-up of mutations alone, study suggests

New research exploring theories of ageing has found that small mutations accumulating in DNA are unlikely to be fully responsible for this process.

29 Sep 2021

Stringent lineage tracing is vital for nerve cell regeneration studies

UT Southwestern stem cell scientists find that stringent lineage tracing is crucial for studies of nerve cell regeneration. Their results, which are published in Cell, show that this tracing is far from routine in the field and suggest that earlier studies reporting "striking" regeneration results must be reexamined.

29 Sep 2021

Cell News and Research

Study investigates the mechanism underlying kidney damage in COVID-19 patients

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Understanding noise-related hearing loss through changes in RNA levels

Long-held theory of cancer-induced immune suppression requires revision, study says

Large-scale SARS-CoV-2 spike protein mutants analysis identifies subclonal variants indicative of within-host viral diversity

Scientists link insulin resistance to increased risk of developing major depressive disorder

Study finds correlation between neutralizing antibody titer and reported vaccine efficacy

Vaccine-induced SARS-CoV2 immune responses decline at similar rates as those after infection, study finds

Novel strategy for in vitro cell-selective protection has potential for use in adoptive cell therapy

Two proteins joined together using a free-standing, rigid link

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Duke neurobiologists show how the rigors of natural selection and evolution have shaped the retinas

Aging may not be due to build-up of mutations alone, study suggests

Stringent lineage tracing is vital for nerve cell regeneration studies

Researchers devise novel technique to count elusive circulating tumor cells

Human coronavirus replicates in bats without using the spike protein

Study reports on ex vivo drug delivery system for delivering MSCs to kidney disease patients

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