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Injecting PAP may reduce chronic pain: Research

A study published in the Aug. 4, 2010 issue of the Journal of Neuroscience introduces an enzyme that could pack a big punch in the battle against chronic pain. Its name is prostatic acid phosphatase or PAP for short. According to researchers at the University of North Carolina at Chapel Hill, PAP blocks pain in animal models by siphoning off a molecule called PIP2—a critical component of the chemical cascade behind chronic pain.

5 Aug 2010

Missouri voters reject health reform law's 'individual mandate' to buy insurance

"Missouri law now contains a direct challenge to the federal health care law passed earlier this year. Primary voters approved Proposition C by a wide margin Tuesday. ... The measure is intended to invalidate in Missouri a key element of the federal health care law passed by Congress and signed by President Barack Obama in March. That law requires individuals to purchase health insurance beginning in 2014."

5 Aug 2010

Pakistan floods prompt food shortages, devastate farmland

Pakistanis in the northwest part of the country face "life-threatening shortages" of food after flooding has killed 1,400 and "devastated the lives of more than three million people," Reuters reports. World Food Programme spokesman Amjad Jamal said, "People have lost their food stocks. The markets are not up and running. Shops have collapsed. People are definitely in the greatest need of food" (Ali, 8/4).

5 Aug 2010

Affymax reports second-quarter net income of $17.3M against loss last year

Affymax, Inc. today reported financial results for the second quarter ended June 30, 2010. Net income for the second quarter of 2010 was $17.3 million compared to a net loss of $22.1 million for the second quarter of 2009. The company received milestone payments of $30.0 million from Takeda Pharmaceutical Company Limited for database lock of the Hematide/peginesatide Phase 3 clinical trials.

5 Aug 2010

ECRI Institute and Silverchair relaunch AHRQ's updated NGC, NQMC Web sites

ECRI Institute, an independent nonprofit that researches the best approaches to improving patient care, and its technology subcontractor, Silverchair, today announce the relaunch of two key healthcare Web sites they have developed for the U.S. Agency for Healthcare Research and Quality (AHRQ). The National Guideline Clearinghouse™ (NGC™), www.guideline.gov, and the National Quality Measures Clearinghouse™ (NQMC™), www.qualitymeasures.ahrq.gov, now feature updated design elements, enhanced search functionality, and easier access to all content.

5 Aug 2010

HGC publishes guidelines to protect people using DIY genetic tests

A set of guidelines has been published to protect people using DIY genetic tests for inherited diseases, such as certain types of breast cancer.The guidelines have been drawn up by the Human Genetics Commission (HGC), which hopes to provide the public with greater confidence in genetic testing kits.Companies - many of which are based in the US - have started to sell DIY testing kits over the internet, providing users with an estimate of their risk of inheriting diseases.

5 Aug 2010

Optimer second-quarter net loss decreases to $10.4 million

Optimer Pharmaceuticals, Inc. today reported financial results for the second quarter ended June 30, 2010. Optimer reported a net loss for the second quarter of 2010 of $10.4 million, or $0.27 per share, which was in line with the Company's expectations. This compares to a net loss for the second quarter of 2009 of $12.4 million, or $0.37 per share. The decrease in net loss was primarily due to lower research and development expenses offset by an increase in general and administrative expenses.

5 Aug 2010

Study says quality not hurt when nurse anesthetists work without doc guidance

A new study published Tuesday in Health Affairs suggests that nurse anesthetists' quality of work is not lower when they aren't supervised by a doctor, The Wall Street Journal Health Blog reports. "The background for this is that Medicare won't reimburse for anesthesia services unless a physician is supervising what's going on.

5 Aug 2010

ImmunoGen fourth-quarter 2010 net loss increases to $13.4 million

ImmunoGen, Inc., a biotechnology company that develops targeted anticancer products using its antibody expertise and Targeted Antibody Payload (TAP) technology, today announced financial results for the three-month period and fiscal year ended June 30, 2010.

5 Aug 2010

Foldit players to focus on designing novel proteins

Computer scientists and biochemists at the University of Washington two years ago launched an ambitious project harnessing the brainpower of computer gamers to solve medical problems. The game, Foldit, turns one of the hardest problems in molecular biology into a game a bit reminiscent of Tetris. Thousands of people have now played a game that asks them to fold a protein rather than stack colored blocks or rescue a princess.

5 Aug 2010

Canadian physician organization: Country's health system needs to be 'massively transformed'

The Toronto Star: Canada's largest physician group released a report Tuesday saying that Canada's health system needs to be changed to allow "universal access to prescription drugs and improved outpatient services." The Canadian Medical Association called for the changes because it says the system is insufficient to meet the needs of Canada's aging population.

5 Aug 2010

Excess maternal weight gain predicts high birth weight: Research

Expectant mothers who gain large amounts of weight tend to give birth to heavier infants who are at higher risk for obesity later in life. But it's never been proven that this tendency results from the weight gain itself, rather than genetic or other factors that mother and baby share. A large population-based study from Children's Hospital Boston, looking at two or more pregnancies in the same mother, now provides evidence that excess maternal weight gain is a strong, independent predictor of high birth weight.

5 Aug 2010

AMRI second-quarter adjusted EPS increases to $0.06

AMRI today reported financial and operating results for the second quarter ended June 30, 2010.

5 Aug 2010

Consumer, insurers prepare as more health law provisions will take effect next month

Associated Press: Health care reform hits another milestone next month, with new provisions that include a coverage expansion for young adults and restrictions on an insurer's ability to impose annual coverage limits or to reject children with pre-existing medical conditions. Insurance coverage that starts on or after Sept. 23 will have to comply with these changes and others that were put in place when President Barack Obama signed the health overhaul into law March 23." Many plans won't renew until later on (Murphy, 8/3).

5 Aug 2010

FDA to crack down on devices; Big pharma places riskier bets on biologics

The Associated Press: "Makers of X-ray machines, drug pumps and other medical devices would have to submit more safety information to win federal approval under a proposal designed to tighten regulation of thousands of products reviewed each year. The Food and Drug Administration released recommendations Tuesday night designed to improve oversight of the U.S. device industry, including the government's ability to revoke approval for products that prove unsafe or ineffective" (Perrone, 8/3).

5 Aug 2010

Sigma-Aldrich, NHLBI and BU collaborate in atherosclerotic cardiovascular disease research

Sigma-Aldrich® today announced it has entered into an agreement with the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, and Boston University (BU) to develop methods to measure several potential biomarkers of atherosclerotic cardiovascular disease (CVD) using plasma samples from the NHLBI's Framingham Heart Study (FHS), one of the most prestigious clinical studies in medicine. Funding for the project is provided by the NHLBI to Sigma-Aldrich under a research subaward agreement with BU.

5 Aug 2010

Long-term exposure to valproate leads to bone loss: Study

Scientists are reporting a possible explanation for the bone loss that may occur following long-term use of a medicine widely used to treat epilepsy, bipolar disorder, and other conditions. The drug, valproate, appears to reduce the formation of two key proteins important for bone strength, they said. Their study, which offers a solution to a long-standing mystery, appears in ACS' monthly Journal of Proteome Research.

5 Aug 2010

HF-WBI effective for patients with early stage breast cancer

The American Society for Radiation Oncology (ASTRO) has released evidence-based guidelines to define appropriate fractionation of whole breast irradiation (WBI), finding that hypofractionated (HF) WBI is effective for many patients with early-stage breast cancer. These guidelines are published in the International Journal of Radiation Oncology-Biology-Physics, the official journal of ASTRO.

5 Aug 2010

Anthera second-quarter total operating expenses increase to $7.9 million

Anthera Pharmaceuticals, Inc., today announced financial results and business highlights for the second quarter ended June 30, 2010.

5 Aug 2010

SORT1 pathway holds promise as new target for therapeutic intervention for LDL cholesterol reduction

The true power of genomic research lies in its ability to help scientists understand biological processes, particularly those that - when altered - can lead to disease. This power is demonstrated dramatically in a pair of papers published today in the journal Nature. In the first, a global team of researchers describes 95 different variations across the genome that contribute in different degrees to alterations in blood cholesterol and triglyceride levels in multiple human populations. In the second report, close examination of just one of these common variants not only reveals the involvement of an unexpected genetic pathway in lipid metabolism but also provides a blueprint for using genomic findings to unravel biological connections between lipid levels and coronary heart disease.

5 Aug 2010