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Metformin along with chemotherapy/radiation improves outcomes in head and neck cancer patients

Researchers at the University of Cincinnati College of Medicine have found that adding increasing doses of an approved Type 2 diabetes drug, metformin, to a chemotherapy and radiation treatment regimen in head and neck cancer patients is not well tolerated if escalated too quickly, but allowing slower escalation could be beneficial.

6 Jun 2016

Study finds link between stress hormone and stage of schizophrenia

JCU Associate Professor Zoltan Sarnyai said it was the first meta-analysis study to compare the level of cortisol in a waking patient's body with the stage of schizophrenia they are suffering.

6 Jun 2016

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

A significant proportion of lung cancer patients also have autoimmune disease, which may make them unsuitable for increasingly popular immunotherapy treatments, a team of researchers at UT Southwestern Medical Center's Harold C. Simmons Comprehensive Cancer Center has found.

6 Jun 2016

Scientists use new technique to repair fibrotic liver cells within the organ

Advances in stem cell research have made it possible to convert patients' skin cells into heart cells, kidney cells, liver cells and more in the lab dish, giving researchers hope that one day such cells could replace organ transplantation for patients with organ failure.

3 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

Neuroblastoma tumors shrank, some dramatically, in 80 percent of newly diagnosed, young, high-risk patients enrolled in a Phase II clinical trial that included an experimental monoclonal antibody. The immunotherapy agent was produced on the St. Jude Children's Research Hospital campus where the study is still underway.

3 Jun 2016

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Cancer immunotherapies--drugs that work by making a patient's immune system better at spotting and destroying tumor cells--are increasingly generating headlines. A number of these drugs are now being used for the treatment of melanoma, lung, and kidney cancers, and are showing promise in clinical trials with other diseases as well.

3 Jun 2016

Fluctuations in tRNA may play vital role in cancer metastasis

At any given moment, the human genome spells out thousands of genetic words telling our cells which proteins to make. Each word is read by a molecule known as a tRNA.

3 Jun 2016

Scientists identify cellular mechanisms of altered skin wound repair in elderly patients

Each injury means a little more as individuals age -- more impact and more healing time.

3 Jun 2016

Eating walnuts may offer protection against colon tumors

Eating walnuts may change gut bacteria in a way that suppresses colon cancer, researchers led by UConn Health report in the journal Cancer Prevention Research.

3 Jun 2016

CNIO researchers avoid genetic manipulation to create lab mice with extra-long telomeres

The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre, in collaboration with the Centre's Transgenic Mice Core Unit, has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of what to date has been the standard method: genetic manipulation.

3 Jun 2016

$Sostdc1 gene may play vital role in fracture healing process$

Sostdc1 gene may play vital role in fracture healing process

New identification of a gene involved in the fracture healing process could lead to the development of new therapeutic treatments for difficult-to-heal injuries.

2 Jun 2016

BRCA gene mutations raise risk of breast, ovarian and other cancers

BRCA Share, a public-private BRCA gene datashare initiative, today announced the public release of a large collection of new data on genetic variants in the BRCA1 and BRCA2 genes.

From Quest Diagnostics 2 Jun 2016

Food intolerance expert Dr Gill Hart warns parents over proposed Nestle milk allergy testing

This week Nestle has announced it will develop and market a milk allergy skin patch test for infants, in a bid to boost sales of formula to babies with allergies.

2 Jun 2016

Scientists use optogenetics technique to increase memory in mice brain

Raül Andero Galí, one of the heads of the "Neurobiology of Stress and Addiction" research group at the Institut de Neurociències of the Universitat Autònoma de Barcelona and researcher at Harvard University, published an article in which, for the first time in Spain, optogenetics was used to increase memory.

2 Jun 2016

Study reveals gpihbp1 gene could be novel target for treatment of muscular dystrophy

The average healthy man is 54 percent muscle by mass, but people with muscular dystrophy, an incurable, genetic condition, have almost no muscle at terminal stages of the disease.

2 Jun 2016

RSI-MRI imaging technology can effectively differentiate aggressive prostate cancer

Physicians have long used magnetic resonance imaging (MRI) to detect cancer but results of a University of California San Diego School of Medicine study describe the potential use of restriction spectrum imaging (RSI) as an imaging biomarker that enhances the ability of MRI to differentiate aggressive prostate cancer from low-grade or benign tumors and guide treatment and biopsy.

2 Jun 2016

Laboratory News and Research

Metformin along with chemotherapy/radiation improves outcomes in head and neck cancer patients

Study finds link between stress hormone and stage of schizophrenia

Autoimmune diseases among lung cancer patients may make them unsuitable for immunotherapy

Scientists use new technique to repair fibrotic liver cells within the organ

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

Immunotherapy with experimental monoclonal antibody could reduce neuroblastoma tumors

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Fluctuations in tRNA may play vital role in cancer metastasis

Scientists identify cellular mechanisms of altered skin wound repair in elderly patients

Eating walnuts may offer protection against colon tumors

CNIO researchers avoid genetic manipulation to create lab mice with extra-long telomeres

Sostdc1 gene may play vital role in fracture healing process

BRCA gene mutations raise risk of breast, ovarian and other cancers

Food intolerance expert Dr Gill Hart warns parents over proposed Nestle milk allergy testing

Scientists use optogenetics technique to increase memory in mice brain

Study reveals gpihbp1 gene could be novel target for treatment of muscular dystrophy

RSI-MRI imaging technology can effectively differentiate aggressive prostate cancer

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Experts urge cancer researchers to use old, obese mice for preclinical immunotherapy studies

Using proteomic mass spectrometry imaging to detect malignant melanoma: an interview with Stephen Turner

A guide to density measurement excellence eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics