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New method to synthesize drug candidates for testing

Some drugs may be more effective the longer they last inside the body. To prevent such drugs from being broken down too rapidly, pharmaceutical manufacturers often attach a fluorine-containing structure called a trifluoromethyl group. However, the processes now used require harsh reaction conditions or only work in a small number of cases, limiting their usefulness for synthesizing new drug candidates for testing.

25 Jun 2010

Scientists discover characteristic amyloid plaques in retinas from Alzheimer's disease patients

The nerve cell-damaging plaque that builds up in the brain with Alzheimer's disease also builds up in the retinas of the eyes - and it shows up there earlier, leading to the prospect that noninvasive optical imaging of the eyes could lead to earlier diagnosis, intervention and monitoring of the disease, according to new research.

25 Jun 2010

CHMP adopts positive opinion on pending MAA for SYCREST sublingual tablets

Merck announced that the Committee for Medicinal Products for Human Use adopted a positive opinion on the pending Marketing Authorization Application for SYCREST (asenapine) sublingual tablets. The CHMP has recommended that the European Commission grant a marketing authorization for SYCREST for the treatment of moderate to severe manic episodes associated with bipolar I disorder in adults. The CHMP did not support an indication for the treatment of schizophrenia.

25 Jun 2010

First Edition: June 25, 2010

Today's headlines reflect the latest news about the House passing a temporary ban on cuts in Medicare reimbursements to doctors, while Senate Democrats failed to gain approval for their jobs bill, which included enhanced Medicaid aid to states.

25 Jun 2010

Research findings suggest possible diagnostic test for ALS

A team led by a Los Angeles Biomedical Research Institute researcher developed a novel approach to efficiently identify disease relevant genes in human complex neurological disorders and demonstrated the effectiveness of this method by applying it to Amyotrophic Lateral Sclerosis, or Lou Gehrig's Disease, according to a new study reported online in the journal, Human Molecular Genetics.

25 Jun 2010

Scientist at Children Hospital Los Angeles receives NIH grant to research on meningitis

A white blood cell that normally removes bacteria from the bloodstream helps Escherichia coli (E. coli) accumulate in the blood and enter the brain resulting in the deadly infection known as meningitis. Prasadarao V. Nemani, PhD, a scientist at The Saban Research Institute at Children Hospital Los Angeles plans to find out how this happens with a grant of $1.65 million from the National Institutes of Health - National Institute of Neurological Disorders and Strokes.

25 Jun 2010

PMPRB report: Brand-name drug companies in Canada spent only 7.5% of revenues on R&D in 2009

Research and development spending in Canada by brand-name drug companies has dropped to its lowest level in 20 years, according to the latest annual report of the Patented Medicine Prices Review Board.

25 Jun 2010

IDRI signs Research Collaboration Agreement with PATH

Two global health non-profit organizations headquartered in Seattle, Washington, the Infectious Disease Research Institute and PATH, have entered into a Research Collaboration Agreement to evaluate novel adjuvants for their ability to enhance the immune response of pandemic influenza vaccines in development. The collaboration supports the goal of PATH's influenza vaccine project to advance the development of promising new influenza vaccines focusing on novel technologies that can be accessible, affordable, and available to people in low-resource countries in a global outbreak.

25 Jun 2010

Cyclosporine treatment develops higher de novo cancer risk in liver transplant patients: Researchers

Researchers at Erasmus MC University Medical Centre in The Netherlands found that cyclosporine treatment is a significant risk factor for the development of de novo cancer in liver transplant patients. Full details appear in the July issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

25 Jun 2010

PARP inhibitors may be effective in men with prostate cancer due to BRCA2 alteration: Researchers

The way prostate cancer develops in men who have an altered 'breast cancer gene' is the same route by which breast cancer develops in women with the same mutation, reveals a study published in PLoS Genetics today (Thursday).

25 Jun 2010

Scientists report first preliminary description of bed bug's sialome

With bed bugs reemerging as a nuisance in some parts of the country, scientists are reporting the first preliminary description of the bug's sialome - the saliva proteins that are the secret to Cimex lectularius' ability to suck blood from its human victims and escape to bite again with risking a lethal slap. The findings, which could have medical applications in diagnosing bed bug bites and preventing the itch, appear in ACS' monthly Journal of Proteome Research.

25 Jun 2010

U.N. Secretary-General to ask G20 for additional $60B over 5 years for maternal, child health

U.N. Secretary-General Ban Ki-moon said he plans to ask the G20 to follow through on aid promises and to commit an additional $60 billion over five years for lowering maternal and child mortality rates worldwide, Bloomberg Businessweek reports.

25 Jun 2010

Two experimental drugs have potential to restore pumping strength to failing hearts, study finds

We've all experienced the strong heartbeat that accompanies emotions such as fear and rage. But can the body's natural response to these emotions be used to combat heart failure? Results of a study published online today in the journal Circulation Research present a strong case.

25 Jun 2010

Opinions: Harper and global health; Health workers in developing countries; Funding commitments; DDT, GMO use

Canadian Prime Minister Stephen Harper "can use the relatively intimate setting of the G8's Muskoka meeting to press for a renewal of the G8's commitment to better health for Africans, and help the developed world be truly accountable for its promises," the Globe and Mail writes in an editorial. "The G8's failure to fully fund the historic aid commitments to Africa it made at the 2005 Gleneagles summit" puts the future success of the developing world at risk, the editorial states.

25 Jun 2010

News roundup: Judge approves $712 million settlement for 9/11 emergency workers' health problems; Missouri ballot measure on health overhaul challenged

A judge approved a $712 million health settlement for thousands of emergency workers who responded after the Sept. 11 attack, in spite of objections from some who complained that the deal was unfair. Some workers who say they got sick working at the Ground Zero site argued Wednesday that the settlement shortchanged those suffering from certain types of diseases. One of the key factors in how much workers get paid under the settlement, approved by U.S. District Judge Alvin Hellerstein, depends on the type of disease the person contracted.

25 Jun 2010

Saint Francis Hospital achieves Magnet designation for excellence in nursing services

Saint Francis Hospital has achieved Magnet designation for excellence in nursing services by the American Nurses Credential Center's Magnet Recognition Program. The unanimous decision was based on Saint Francis Hospital's adherence to strict guidelines and criteria for nursing professionalism, quality patient care and teamwork. Only 6 percent of hospitals across the United States currently have the Magnet designation.

25 Jun 2010

UH researchers analyze 'wireless connections' in brain to prevent neurological diseases

Many diseases of brain function, such as epilepsy and schizophrenia, are caused by problems in how neurons communicate with each other. A University of Houston researcher and his team are analyzing these commands and connections in an attempt to prevent those diseases.

25 Jun 2010

Research on safety of endoscopic piecemeal mucosal resection in treatment of large sessile colorectal polyps

Endoscopic resection of large sessile colorectal polyps is increasingly used as an alternative to surgery, but remains challenging because of its technical difficulty, the high risk of complications such as bleeding or perforation, and the possibility of coexisting malignancy.

25 Jun 2010

Report finds countries in Africa face most severe water risks

"African nations led by Somalia, Mauritania and Sudan have the most precarious water supplies in the world while Iceland has the best," according to a report released Thursday, Reuters reports.

25 Jun 2010

GI symptoms in peritoneal dialysis patients correlated with chronic renal failure

Gastrointestinal (GI ) symptoms are proven to be more common in patients undergoing peritoneal dialysis than in patients with chronic renal failure having hemodialysis. However, whether the onset of these GI symptoms is related to the chronic renal failure itself, its treatment, or alternatively, other factors, is still unknown

25 Jun 2010

Research News and Research

New method to synthesize drug candidates for testing

Scientists discover characteristic amyloid plaques in retinas from Alzheimer's disease patients

CHMP adopts positive opinion on pending MAA for SYCREST sublingual tablets

First Edition: June 25, 2010

Research findings suggest possible diagnostic test for ALS

Scientist at Children Hospital Los Angeles receives NIH grant to research on meningitis

PMPRB report: Brand-name drug companies in Canada spent only 7.5% of revenues on R&D in 2009

IDRI signs Research Collaboration Agreement with PATH

Cyclosporine treatment develops higher de novo cancer risk in liver transplant patients: Researchers

PARP inhibitors may be effective in men with prostate cancer due to BRCA2 alteration: Researchers

Scientists report first preliminary description of bed bug's sialome

U.N. Secretary-General to ask G20 for additional $60B over 5 years for maternal, child health

Two experimental drugs have potential to restore pumping strength to failing hearts, study finds

Opinions: Harper and global health; Health workers in developing countries; Funding commitments; DDT, GMO use

News roundup: Judge approves $712 million settlement for 9/11 emergency workers' health problems; Missouri ballot measure on health overhaul challenged

Saint Francis Hospital achieves Magnet designation for excellence in nursing services

UH researchers analyze 'wireless connections' in brain to prevent neurological diseases

Research on safety of endoscopic piecemeal mucosal resection in treatment of large sessile colorectal polyps

Report finds countries in Africa face most severe water risks

GI symptoms in peritoneal dialysis patients correlated with chronic renal failure

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