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Study uses genome- and epigenome-editing tools to determine disease-causing variants

A paper receiving advance online release in Nature Medicine describes a strategy for meeting one of today's most significant challenges in genomic medicine - determining whether a specific DNA variant in the non-protein-coding genome is the actual disease-causing variant of an associated disease risk.

24 Sep 2015

New analysis shows rare gene mutations cause half of all ASD cases

A team led by researchers at Cold Spring Harbor Laboratory (CSHL) this week publishes in PNAS a new analysis of data on the genetics of autism spectrum disorder (ASD).

23 Sep 2015

TSRI scientists awarded grant from Gates Foundation to develop revolutionary alternative HIV/AIDS vaccine

Scientists from the Florida campus of The Scripps Research Institute have been awarded up to nearly $6 million dollars from the Bill & Melinda Gates Foundation to develop a revolutionary HIV/AIDS alternative vaccine that has demonstrated great potential in animal models.

23 Sep 2015

Johns Hopkins scientists discover earliest premalignant genetic changes that mark potential onset of lung cancer

Working with tissue, blood and DNA from six people with precancerous and cancerous lung lesions, a team of Johns Hopkins scientists has identified what it believes are among the very earliest “premalignant” genetic changes that mark the potential onset of the most common and deadliest form of disease.

23 Sep 2015

University of Adelaide study sheds light on the activity of cancer-suppressing gene

University of Adelaide researchers have uncovered the role played by a gene which suppresses the development of cancer. The findings, published in the journal PLOS ONE, open new opportunities for scientists to find treatments for cancer.

23 Sep 2015

Novel graphene oxide-based biosensor may speed up development of new drugs against HIV, cancer

Longing to find a cure for cancer, HIV and other yet incurable diseases, researchers have already tried out hundreds of drugs, each requiring preclinical and clinical testing with live subjects. How many chemical agents more to try? Moving at such rate, will we find the cure during our lifetime? One of the easiest ways to speed up the drug development process is to simply perform it outside of the living body (e.g., by watching the substances react with the smallest pieces of live tissue and thus quickly predicting the overall effect it will make to the body when inside).

23 Sep 2015

Study demonstrates potential of FCPCs as new source for cartilage regeneration

The self-repair of injured cartilage is difficult for several reasons, foremost of which is the lack of blood supply to the tissue. Therapeutic efforts aimed at cartilage repair are often not optimal. Surgical repair techniques often lead to the formation of fibrocartilage, which is weaker and less durable. Although cell transplantation aimed at cartilage repair has been carried out using mesenchymal stem cells (MSCs), varying outcomes have resulted, despite the propensity of MSCs to proliferate and differentiate.

23 Sep 2015

Prashant Mahajan awarded $5.76 million grant to study how febrile infants can avoid invasive procedures

Prashant Mahajan, M.D., professor of Pediatrics and Emergency Medicine, chief of the Division of Emergency Medicine in the Department of Pediatrics at Wayne State University and Children's Hospital of Michigan, has been awarded a five-year, $5.76 million grant (1R01HD085233) by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health.

23 Sep 2015

Findings may suggest new therapeutic target to combat memory loss in aging, Alzheimer's disease

Northwestern Medicine scientists have examined activity in a little-studied part of the brain associated with memory and found for the first time the reason that neurons there become more active in old age, findings that may suggest a new target for future therapies to combat memory loss in aging and Alzheimer's disease.

23 Sep 2015

NJIT President Joel Bloom to be honored as Educator of the Year

The Research & Development Council of New Jersey will honor the winners of the 2015 Edison Patent Awards at the 36th Edison Patent Awards Ceremony & Reception on November 12, 2015. Over 50 inventors and 12 New Jersey companies and universities will be recognized at the event.

23 Sep 2015

UCSF researchers successfully separate human muscle stem cells

UC San Francisco researchers have successfully isolated human muscle stem cells and shown that the cells could robustly replicate and repair damaged muscles when grafted onto an injured site. The laboratory finding paves the way for potential treatments for patients with severe muscle injury, paralysis or genetic diseases such as muscular dystrophy.

23 Sep 2015

Gene study reveals how a strain of E. coli evolved to become potentially fatal infection

A strain of E. coli became a potentially fatal infection in the UK around 30 years ago, when it acquired a powerful toxin, a gene study has revealed.

22 Sep 2015

FDA approves LONSURF for treatment of patients with metastatic colorectal cancer

Taiho Oncology, Inc. (U.S.), a subsidiary of Taiho Pharmaceutical Co., Ltd. (Japan), today announced that the U.S. Food and Drug Administration approved LONSURF (trifluridine and tipiracil), formerly known as TAS-102, for the treatment of patients with metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy.

22 Sep 2015

GW to become new host of Institute for Infrastructure Protection

As of Oct. 1 the George Washington University will be the new host of the Institute for Infrastructure Protection (I3P), a national consortium of leading institutions addressing cybersecurity challenges affecting critical infrastructures.

22 Sep 2015

Innovative way may stop spread of glioblastoma multiforme

Scientists at the University of Toledo Health Science Campus and Van Andel Research Institute have discovered an innovative way that may stop the spread of the most lethal and aggressive brain cancer glioblastoma multiforme (GBM). In laboratory studies, scientists demonstrated that activating a specific family of proteins halted cancer cell migration into healthy tissue.

22 Sep 2015

Outbreak of Bordetella parapertussis occurred in Southeastern Minnesota in 2014: Study

Study reports that an outbreak of Bordetella parapertussis occurred in 2014 in Southeastern Minnesota, in the months of October through December. This research is presented at ASM's 55th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC/ICC).

22 Sep 2015

Study compares effectiveness of nafcillin and cefazolin in patients with MSSA blood stream infections

Research comparing clinical outcomes between patients receiving nafcillin and cefazolin for treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia shows that overall treatment failure rate among patients receiving cefazolin was no worse than nafcillin, and significantly fewer adverse effects were documented for those receiving cefazolin.

22 Sep 2015

Vaginal silicone ring may protect women against HIV, herpes virus

Researchers at University Jean Monnet of Saint-Etienne, France have succeeded in developing a vaginal silicone ring that delivers molecules that act on both HIV and herpes virus. This research is presented at the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC/ICC).

21 Sep 2015

UF researchers find a way to kill insects that carry devastating citrus greening bacterium

Researchers with the University of Florida and several other institutions have found a way in laboratory tests to use 200 times less insecticide and yet still kill as many insects that carry the devastating citrus greening bacterium.

21 Sep 2015

Novel nebuliser could one day deliver life-saving cancer drugs

A revolutionary nebuliser developed by RMIT University researchers could one day deliver life-saving cancer drugs and vaccines traditionally given by injection.

21 Sep 2015

Laboratory News and Research

Study uses genome- and epigenome-editing tools to determine disease-causing variants

New analysis shows rare gene mutations cause half of all ASD cases

TSRI scientists awarded grant from Gates Foundation to develop revolutionary alternative HIV/AIDS vaccine

Johns Hopkins scientists discover earliest premalignant genetic changes that mark potential onset of lung cancer

University of Adelaide study sheds light on the activity of cancer-suppressing gene

Novel graphene oxide-based biosensor may speed up development of new drugs against HIV, cancer

Study demonstrates potential of FCPCs as new source for cartilage regeneration

Prashant Mahajan awarded $5.76 million grant to study how febrile infants can avoid invasive procedures

Findings may suggest new therapeutic target to combat memory loss in aging, Alzheimer's disease

NJIT President Joel Bloom to be honored as Educator of the Year

UCSF researchers successfully separate human muscle stem cells

Gene study reveals how a strain of E. coli evolved to become potentially fatal infection

FDA approves LONSURF for treatment of patients with metastatic colorectal cancer

GW to become new host of Institute for Infrastructure Protection

Innovative way may stop spread of glioblastoma multiforme

Outbreak of Bordetella parapertussis occurred in Southeastern Minnesota in 2014: Study

Study compares effectiveness of nafcillin and cefazolin in patients with MSSA blood stream infections

Vaginal silicone ring may protect women against HIV, herpes virus

UF researchers find a way to kill insects that carry devastating citrus greening bacterium

Novel nebuliser could one day deliver life-saving cancer drugs

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