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Researchers develop hPSC-based system for producing connections between neurons in the brain

Human stem cells can be differentiated to produce other cell types, such as organ cells, skin cells, or brain cells. While organ cells, for example, can function in isolation, brain cells require synapses, or connectors, between cells and between regions of the brain. In a new study published in Restorative Neurology and Neuroscience, researchers report successfully growing multiple brain structures and forming connections between them in vitro, in a single culture vessel, for the first time.

16 Jun 2015

Researchers suggest link between solar storms and incidences of RA and GCA

What began as a chat between husband and wife has evolved into an intriguing scientific discovery. The results, published in May in BMJ (formerly British Medical Journal) Open, show a "highly significant" correlation between periodic solar storms and incidences of rheumatoid arthritis (RA) and giant cell arteritis (GCA), two potentially debilitating autoimmune diseases.

16 Jun 2015

Understanding crosstalk between cells in the pancreas can help treat diabetes

Sometimes, listening in on a conversation can tell you a lot. For Mark Huising, an assistant professor in the Department of Neurobiology, Physiology and Behavior at the UC Davis College of Biological Sciences, that crosstalk is between the cells that control your body's response to sugar, and understanding the conversation can help us understand, and perhaps ultimately treat, diabetes.

16 Jun 2015

DAPK1 protein may be a promising new therapeutic target for most aggressive breast cancers

Although traditionally understood to induce death in cancer cells, researchers at The University of Texas MD Anderson Cancer Center have discovered that the DAPK1 protein is actually essential for growth in breast and other cancers with mutations in the TP53 gene. This discovery indicates DAPK1 may be a promising new therapeutic target for many of the most aggressive cancers.

16 Jun 2015

Novartis presents positive Phase III results of Farydak therapy at EHA

Novartis today presented results from a pivotal Phase III clinical trial exploratory subgroup analysis showing a 7.8-month improvement in median progression-free survival when using Farydak in combination with bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma who had received two or more prior regimens, including bortezomib and an immunomodulatory agent.

16 Jun 2015

NTCELL Phase I/IIa clinical study meets primary endpoint in patients with Parkinson’s disease

Living Cell Technologies Limited today announced results from a Phase I/IIa clinical study of NTCELL, an experimental regenerative cell therapy being studied as a disease-modifying agent in Parkinson’s disease. The study, conducted in four patients in New Zealand, met its primary endpoint of safety, showing NTCELL implantation was well tolerated, with no adverse events considered to be related to NTCELL.

15 Jun 2015

Researchers identify gene variant that makes breast cancer cells more aggressive

A particular human gene variant makes breast cancer cells more aggressive. Not only are these more resistant to chemotherapy but also leave the primary tumour and establish themselves in other parts of the body in the form of metastases. An international group of researchers led by Lukas Kenner of MedUni Vienna has now identified a gene, AF1q, as being substantially responsible for this and recognized it as a possible starting point for more accurate diagnosis and potential targeted therapeutic approaches.

15 Jun 2015

High throughput media preparation at the Institut Curie

The Institut Curie (Paris, France), a world leader in oncology research, has reported how it has standardised on using MEDIACLAVE media preparation and MEDIAJET automated petri dish filling systems from INTEGRA Biosciences to prepare its petri dishes.

From INTEGRA Biosciences 14 Jun 2015

Active video games can be a source of physical activity, shows UT study

The increasing use of video games is often blamed for children's lack of interest in physical activity, but a study by the University of Tennessee, Knoxville, recently published in the Games for Health Journal suggests that active video games may actually be a source of moderate or intense physical activity in children five to eight years old.

14 Jun 2015

New TSRI study integrates neuroscience and psychological research to understand sleep, memory

In Macbeth, Shakespeare describes sleep as "the death of each day's life," but he may have gotten it wrong. Sleep, as it turns out, may be the one thing that keeps our memories alive and intact.

12 Jun 2015

Researchers show how a new drug speeds tissue regeneration in animal models

The concept sounds like the stuff of science fiction: take a pill, and suddenly new tissues grow to replace damaged ones. Researchers at Case Western Reserve and UT Southwestern Medical Center this week announced that they have taken significant steps toward turning this once-improbable idea into a vivid reality.

12 Jun 2015

Daily dose of aspirin effective at blocking breast tumor growth

"Take two aspirin and call me in the morning" has been the punchline for countless jokes. Could it also be good advice for cancer patients? A lab study to appear in the July 2015 issue of Laboratory Investigation found that a daily dose of aspirin was effective at blocking breast tumor growth. Previous studies have already shown a similar effect on colon, gastrointestinal, prostate, and other cancers.

12 Jun 2015

Sebia’s Capillarys 3 Tera automated electrophoresis solution receives CE mark

Sebia, the world leader in capillary electrophoresis, today announces that Capillarys 3 Tera now has the CE mark for HbA1c and serum protein testing, and immunotyping. The CE mark for these tests is the first step in bringing the Capillarys 3 suite to market.

12 Jun 2015

USC Stem Cell scientist named 2015 Pew-Stewart scholar for cancer research

USC Stem Cell researcher Min Yu, MD, PhD, is one of five early-career scientists to be named a 2015 Pew-Stewart scholar for cancer research. As part of this honor, she will receive $240,000 over four years to advance the understanding of metastatic breast cancer.

11 Jun 2015

Dietary compounds in milk-based products may protect against cardiovascular risk

The Maillard reaction is a chemical reaction between amino acids and reducing sugars that results in browned foods like seared steaks and toasted bread. When proteins and sugars are mixed together and heated, new chemical compounds are formed. Some are responsible for new flavors and some, according to a new study published in the Journal of Dairy Science, may protect us against cardiovascular disease.

11 Jun 2015

Common antibiotic azithromycin effectively kills many multidrug-resistant bacteria

Contrary to current medical dogma, researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report that the common antibiotic azithromycin kills many multidrug-resistant bacteria very effectively — when tested under conditions that closely resemble the human body and its natural antimicrobial factors.

11 Jun 2015

Protein-signaling process accelerates work of gene mutation linked to common form of adult leukemia

In preliminary experiments with mice and lab-grown cells, Johns Hopkins Kimmel Cancer Center scientists have found that a protein-signaling process accelerates the work of the gene most frequently mutated in a common form of adult leukemia and is likely necessary to bring about the full-blown disease.

11 Jun 2015

Scientists and clinicians from across the UK come together to address treatment of brain tumors

In an exciting step forward to finding a cure for brain tumours, which kill more children and adults under the age of 40 than any other cancer, the national charity Brain Tumour Research brought together a group of leading brain tumour scientists and clinicians to help accelerate vital research into this devastating disease.

11 Jun 2015

Novel combination of non-toxic dietary and hyperbaric oxygen therapies doubles survival time in cancer model

A team of researchers from the Hyperbaric Biomedical Research Laboratory at the University of South Florida (USF) doubled survival time in an aggressive metastatic cancer model using a novel combination of non-toxic dietary and hyperbaric oxygen therapies.

11 Jun 2015

New method identifies harmful bacteria levels on recreational beaches

An international team, led by researchers at the University of Miami Rosenstiel School of Marine and Atmospheric Science, has developed a new, timelier method to identify harmful bacteria levels on recreational beaches. The new model provides beach managers with a better prediction tool to identify when closures are required to protect beachgoers from harmful contaminates in the water.

11 Jun 2015

Laboratory News and Research

Researchers develop hPSC-based system for producing connections between neurons in the brain

Researchers suggest link between solar storms and incidences of RA and GCA

Understanding crosstalk between cells in the pancreas can help treat diabetes

DAPK1 protein may be a promising new therapeutic target for most aggressive breast cancers

Novartis presents positive Phase III results of Farydak therapy at EHA

NTCELL Phase I/IIa clinical study meets primary endpoint in patients with Parkinson’s disease

Researchers identify gene variant that makes breast cancer cells more aggressive

High throughput media preparation at the Institut Curie

Active video games can be a source of physical activity, shows UT study

New TSRI study integrates neuroscience and psychological research to understand sleep, memory

Researchers show how a new drug speeds tissue regeneration in animal models

Daily dose of aspirin effective at blocking breast tumor growth

Sebia’s Capillarys 3 Tera automated electrophoresis solution receives CE mark

USC Stem Cell scientist named 2015 Pew-Stewart scholar for cancer research

Dietary compounds in milk-based products may protect against cardiovascular risk

Common antibiotic azithromycin effectively kills many multidrug-resistant bacteria

Protein-signaling process accelerates work of gene mutation linked to common form of adult leukemia

Scientists and clinicians from across the UK come together to address treatment of brain tumors

Novel combination of non-toxic dietary and hyperbaric oxygen therapies doubles survival time in cancer model

New method identifies harmful bacteria levels on recreational beaches

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