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Accelerating the development of new cancer drugs

A phase I clinical trial enrolled its first patient only two days after U.S. Food and Drug Administration clearance of the experimental drug for a first-in-human cancer trial, a milestone that normally takes three to six months. Investigators from The University of Texas M. D. Anderson Cancer Center and pharmaceutical company AstraZeneca have reported their work in the Journal of Clinical Oncology published online on August 3rd.

4 Aug 2009

Women and minorities under-represented in trials

Enrollment demographics published in many U.S. vascular surgery randomized control trials (RCTs) under-represent women as well as race or ethnic minorities, according to a new study published in the Society for Vascular Surgery’s August 2009 issue of the Journal of Vascular Surgery.

4 Aug 2009

New method selectively kills metastatic melanoma

An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma – a cancer that is highly resistant to current treatment strategies.

4 Aug 2009

Antidepressant use becoming more common in the United States

A marked and broad expansion in antidepressant treatment occurred among Americans older than 6 years between 1996 and 2005, although treatment rates remain low among racial and ethnic minorities, according to a report in the August issue of Archives of General Psychiatry.

4 Aug 2009

Carbon nanosensor sniffs out kidney disease

A carbon nanosensor “electronic nose” - first developed by Technion-Israel Institute of Technology researchers to detect cancer from breath samples - has been modified to identify chronic renal failure (CRF).

4 Aug 2009

Heavy drinkers have much higher risk of developing cancer

Heavy drinkers of beer and spirits face a much higher risk of developing cancer than the population at large, says a group of Montreal epidemiologists and cancer researchers.

4 Aug 2009

Tuberculosis drugs under development could have large impact on the disease

The latest drug regimens, vaccines and diagnostic tools under development to combat tuberculosis could have a potentially large impact on the disease once they become available, according to research findings published in the Aug. 3 early edition online of the Proceedings of the National Academy of Sciences.

4 Aug 2009

Virtual reality users adjust their identity to be consistent with that of their avatars

Creating a Second Life avatar, or virtual representation of oneself, that is thin and physically fit may encourage individuals to become healthier and more physically fit in their real lives, according to a study by researchers at RTI International.

4 Aug 2009

Discovery of novel tumor suppressor

La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia.

4 Aug 2009

Stem cell technology innovation could reduce the number of animal experiments

Researchers from the University of Bath are embarking on a project to use stem cell technology that could reduce the number of animal experiments used to study conditions such as motor neurone disease.

4 Aug 2009

Elevated cholesterol levels in midlife raises risk of late-life dementia

Elevated cholesterol levels in midlife - even levels considered only borderline elevated - significantly increase the risk of Alzheimer's disease and vascular dementia later in life, according to a new study by researchers at Kaiser Permanente's Division of Research and the University of Kuopio in Finland. The study appears in the journal Dementia & Geriatric Cognitive Disorders.

4 Aug 2009

Eye movements of Parkinson’s disease patients during sentence comprehension support subcortical role in processing syntax

The study of the neural basis of language has largely focused on regions in the cortex – the outer brain layers thought by many researchers to have expanded during human evolution.

4 Aug 2009

The extremes of BMI a cause for concern in liver transplantation

A recent study by doctors at the University of Washington explained that patients who are significantly underweight or very severely obese prior to liver transplantation are at increased risk of death following transplantation surgery.

4 Aug 2009

Divers who hold breath for several minutes elevate a marker for brain damage

Divers who held their breath for several minutes had elevated levels of a protein that can signal brain damage, according to a new study from the Journal of Applied Physiology. However, the appearance of the protein, S100B, was transient and leaves open the question of whether lengthy apnea (breath-holding) can damage the brain over the long term.

4 Aug 2009

New findings on role of diet on breast cancer risk

How you eat may be just as important as how much you eat, if mice studies are any clue. Cancer researchers have long studied the role of diet on breast cancer risk, but results to date have been mixed.

4 Aug 2009

Public baffled by health care arguments

As members of Congress head home for the summer recess, they will use the time to either sell to their constituents the national health care and insurance overhaul being fiercely debated in Washington, or deep-six it.

4 Aug 2009

Will emphasis on prevention bring health costs down?

If there is one thing that both parties can agree on in the health overhaul debate, it’s the need to build a health system that promotes prevention rather than just manages disease.

4 Aug 2009

New bio-hybrid materials could be used as sensors, catalysts, drug-delivery systems, more

Bacteria play a role in myriad industrial processes from fermentation to cleaning up environmental pollution. But floating freely in solution, the microbial cells constantly multiply, generating biomass that must be removed periodically, causing downtime. Additionally, the microorganisms cannot be localized to a specific region of interest.

3 Aug 2009

FDA approves Livalo (pitavastatin), a new cholesterol-lowering drug

The U.S. Food and Drug Administration today approved the 4 milligram maximum dose of Livalo (pitavastatin), a drug intended to improve blood cholesterol levels in persons with elevated or abnormal blood cholesterol levels.

3 Aug 2009