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Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Researchers investigated the effects of SARS-CoV-2 spike mutations on antiviral restriction mediated by interferon-induced transmembrane proteins and guanylate binding proteins.

11 Mar 2022

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Researchers defined a novel polynucleotide-based Distinctiveness metric to capture the proteome-level differences of emerging SARS-CoV-2 variants and lineages against all previously identified ones.

11 Mar 2022

Multi-institutional teams awarded grant support from the Starr Cancer Consortium

Two multi-institutional teams led by Weill Cornell Medicine scientists have been awarded grant support from the Starr Cancer Consortium. Both grants will fund work applying new technologies to develop more detailed knowledge of tumor biology, with one team focusing on Hodgkin lymphoma and the other on the purity of tumor samples on pathology slides.

10 Mar 2022

Researchers identify motor neuron toxin associated with ALS

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases.

10 Mar 2022

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

In a new study, researchers presented the origins and evolution of the SARS-CoV-2 lineage B.1.1.7 in the United Kingdom.

10 Mar 2022

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

A new study provides an overview of the use of mathematical modeling to determine severe acute respiratory syndrome coronavirus 2 kinetics.

9 Mar 2022

Research sheds light on important events that may play a role in infertility

Everyone considers sperm to be made exclusively by males. But did you know that females also make sperm? Well, it turns out that females also contribute to what makes a sperm a sperm.

8 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

SARS-CoV-2 spike protein characteristics responsible for viral evolution in human hosts

Researchers directly compared the pre-fusion spikes of SARS-CoV-2 Alpha and Beta variants with the original Wuhan strain and the D614G-only variant.

8 Mar 2022

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

A new study examined a unique case of extended viral shedding in an immunocompromised patient that produced a series of SARS-CoV-2 immune escape mutations over a seven-month period.

8 Mar 2022

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

Researchers identified recurrent mutations in SARS-CoV-2.

8 Mar 2022

French study shows COVID vaccine efficacy 94% against severe outcomes

A recent paper published on the medRxiv preprint server utilized data from three national databases containing an abundance of information on Covid-19 screening (SI-DEP), vaccination (VAC-SI), and hospitalizations (SI-VIC) in France to provide additional perspectives on vaccine effectiveness and its evolution over the year 2021 in the French context.

7 Mar 2022

Omicron-specific mRNA vaccine generates immune responses in mice, hamsters and Macaques

Researchers develop an Omicron variant mRNA vaccine that is be more potent in generating nAbs as compared to other available vaccines.

6 Mar 2022

New micro-protein supports cell division and proliferation during nutrient scarcity

Researchers from the University of Eastern Finland and the University of Montreal (Canada) have discovered that a micro-protein, which they named Nrs1, supports cell division and proliferation when nutrients are scarce.

4 Mar 2022

A new method to produce complex natural products in amoebae

A research team at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute in Jena, Germany has developed a new method to produce complex natural products in amoebae.

4 Mar 2022

Patterns of bat β-coronaviruses evolution

Researchers conduct an evolutionary analysis of SARS-CoV-2-related bat β-coronavirus genomes.

4 Mar 2022

Study finds how genetic baggage can accumulate in the genomes of normal and mutant animals

You are probably familiar with the term that some people carry "a lot of extra baggage." Usually that term refers to that person's emotional history, but in genetics and our genomes, "extra baggage" can also describe the transposons lurking in our genomes, a historical record of our genomes surviving traumatic invasions during evolution.

4 Mar 2022

Evolution News and Research

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Multi-institutional teams awarded grant support from the Starr Cancer Consortium

Researchers identify motor neuron toxin associated with ALS

Origins and evolutions of SARS-CoV-2 Alpha variant in the UK

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

Research sheds light on important events that may play a role in infertility

How will mutations change the SARS-CoV-2 spike protein in the future?

SARS-CoV-2 spike protein characteristics responsible for viral evolution in human hosts

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

Recurrent mutations across the SARS-CoV-2 genome associated with long-term infections in immunodeficient patients

French study shows COVID vaccine efficacy 94% against severe outcomes

Omicron-specific mRNA vaccine generates immune responses in mice, hamsters and Macaques

New micro-protein supports cell division and proliferation during nutrient scarcity

A new method to produce complex natural products in amoebae

Patterns of bat β-coronaviruses evolution

Study finds how genetic baggage can accumulate in the genomes of normal and mutant animals

Theoretical biologists capture the mechanisms underlying evolvability

World's first Microhub makes spatial context accessible for all

Study explores coronavirus surveillance in bats from Argentina

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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