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Trial of unique malaria vaccine candidate to begin

In a move that highlights the strength of public-private collaboration in tackling international health challenges, the Maryland-based company Sanaria Inc., with support from the PATH Malaria Vaccine Initiative (MVI), has initiated a Phase 1 clinical trial - the first tests in adult volunteers - of its unique malaria vaccine candidate. Unlike other malaria vaccine candidates, Sanaria's approach deploys a weakened form of the whole malaria parasite harvested from irradiated mosquitoes instead of small portions of the parasite.

23 Apr 2009

Link found between vitamin D insufficiency and asthma severity

Serum levels of vitamin D in more than 600 Costa Rican children were inversely linked to several indicators of allergy and asthma severity, including hospitalizations for asthma, use of inhaled steroids and total IgE levels, according to a study that will appear in the first issue for May of the American Journal of Respiratory and Critical Care Medicine.

23 Apr 2009

Discovery of molecule that could improve success of blood stem cell transplants

University of British Columbia researchers have discovered a "molecular key" that could help increase the success of blood stem cell transplants, a procedure currently used to treat diseases such as leukemia, Hodgkin's lymphoma and aplastic anemia.

22 Apr 2009

Using combinatorial libraries to engineer genetic circuits advances synthetic biology

Streamlining the construction of synthetic gene networks has led a team of Boston University researchers to develop a technique that couples libraries of diversified components with computer modeling to guide predictable gene network construction without the back and forth tweaking.

22 Apr 2009

Many teens who smoke marijuana use it as a medication, not as a means of getting high

When legal therapies let them down, some teens turn to marijuana.

22 Apr 2009

Collagen bioscaffolds used to treat diabetic ulcers, save limbs

San Diego surgeons report that they have been successfully utilizing a collagen bioscaffold material developed by Irvine-based Pegasus Biologics, Inc. to complement soft tissue repair and regeneration among high risk wound patients.

22 Apr 2009

Seattle Genetics presents new data on antibody-drug conjugate

Seattle Genetics, Inc. has announced that data from its antibody-drug conjugate (ADC) programs, SGN-35 and SGN-75, were presented at the 2009 Annual Meeting of the American Association for Cancer Research (AACR) being held in Denver, CO. Preclinical data with SGN-35 further elucidate its mechanism of action and demonstrate its superior antitumor activity in lymphoma compared with non-targeted agents. In addition, data with SGN-75 indicate its therapeutic potential in multiple types of solid tumors.

22 Apr 2009

Test for hormones in blood not reflective of hormones in breast tissue; breast cancer risk

Many studies determine hormone levels in the blood as a marker of breast cancer risk.

22 Apr 2009

Discovery of new gene that stimulates the release of calcium in cells

International research collaborators have identified a new family of proteins, TPC2 (two-pore channels), that facilitates calcium signaling from specialized subcellular organelles.

22 Apr 2009

Scientists identify dozens of proteins the dengue fever virus depends upon

By painstakingly silencing genes one at a time, scientists at Duke University Medical Center have identified dozens of proteins the dengue fever virus depends upon to grow and spread among mosquitoes and humans.

22 Apr 2009

Scientists develop drugs to block skin cancer protein

Scientists have developed a potent group of potential drug candidates to treat skin cancer, according to a study in the Journal of Medicinal Chemistry today (Thursday).

22 Apr 2009

Physical activity counseling increases physical activity of older people

The research conducted at the Finnish Center for Interdisciplinary Gerontology at the University of Jyväskylä shows that physical activity counseling has positive effects on the mobility of older people.

22 Apr 2009

NSAIDs do not prevent Alzheimer's disease or other forms of dementia

A new study shows that nonsteroidal anti-inflammatory drugs (NSAIDs), such as the pain relievers ibuprofen and naproxen, do not prevent Alzheimer's disease or other forms of dementia.

22 Apr 2009

Organic biosensor detects onset of acute myocardial ischemia

Engineering researchers at the University of Arkansas have fabricated and tested a unique biosensor that measures concentrations of potassium and hydrogen ions in the human heart with high specificity.

22 Apr 2009

Palliative care skills training needed for health-care staff in sub-Saharan Africa

A new study, led by Lucy Selman and colleagues from King's College London, has found that patients with incurable, progressive diseases and their family carers in sub-Saharan Africa often do not receive enough information about the patient's disease and its management, which impacts negatively on their ability to cope with illness.

22 Apr 2009

Researchers create chemicals that kill the most deadly malaria-causing parasite

Researchers at the University of Leeds have developed chemicals which kill the most deadly malaria-causing parasite, Plasmodium falciparum - including those resistant to existing drugs.

22 Apr 2009

Liquid calorie intake a big cause of weight gain

Liwei Chen, MD, PhD, Assistant Professor of Epidemiology at the LSU Health Sciences Center New Orleans School of Public Health, is the lead author of a research paper showing that weight gain and obesity are more linked to an increase in liquid calories, particularly sugar-sweetened beverages, than calories from solid food.

22 Apr 2009

Genetic predisposition to impulsivity is a trait predictive of alcoholism

Solving the age-old chicken and the egg dilemma, Indiana University-Purdue University Indianapolis researchers report that genetic predisposition to impulsivity is a trait predictive of alcoholism.

22 Apr 2009

Media ignores health consequences of drink driving among celebrity DUI stories

The recent drinking and driving (DUI) arrests of celebrities - Paris Hilton, Nicole Ritchie, Michelle Rodriguez and Lindsay Lohan - yielded widespread news coverage, however, very little of it offered any public health context, according to a new report by researchers from the Johns Hopkins Bloomberg School of Public Health's Center for Injury Research and Policy.

22 Apr 2009