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New combination treatment offers hope for older patients with mantle cell lymphoma

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting.

11 Dec 2023

Synbiotic formula shows promise in reducing long COVID symptoms

Study finds that the synbiotic preparation SIM01 significantly reduces post-acute COVID-19 syndrome symptoms in patients, including fatigue, memory issues, and gastrointestinal distress, indicating its potential as a treatment for long COVID.

11 Dec 2023

Study finds tree nuts as snack alternative boost metabolic health in young adults

Study found that replacing typical carbohydrate snacks with tree nuts in young adults' diets for 16 weeks improves metabolic health, with females showing reduced waist circumference and lipid biomarkers, and males enhanced insulin sensitivity, without other dietary changes.

11 Dec 2023

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third-generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm.

11 Dec 2023

New SARS-CoV-2 variant JN.1 shows increased transmissibility and immune resistance

A Japanese study published in BioRxiv explores the virological characteristics of the SARS-CoV-2 JN.1 variant, finding it has a higher effective reproductive number and stronger resistance to immunity from other variants, potentially due to the L455S spike protein mutation.

11 Dec 2023

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

A study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests that CAR-T immunotherapy remains a viable option for patients who have lymphoma that goes into remission before the cell therapy begins.

11 Dec 2023

MD Anderson researchers report early success of novel menin-targeted therapies in leukemia

Two clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated early positive results from novel therapies targeting menin for the treatment of relapsed or refractory acute leukemias with specific genetic alterations.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

Phase 2 trial data shows safety, tolerability and efficacy of imlifidase in GBS patients

Hansa Biopharma today announced positive high-level data from the 15-HMedIdeS-09 phase 2 trial that demonstrated imlifidase was safe and well tolerated when administered prior to standard of care, including rapid improvement in disease-related efficacy measures.

11 Dec 2023

COVID-19 significantly raises risk of severe complications in pregnant women

Study found that pregnant mothers with COVID-19 face a significantly higher risk of severe maternal morbidity (SMM), including adult respiratory distress syndrome and acute renal failure, emphasizing the urgent need for their early diagnosis and treatment.

10 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

The University of Texas MD Anderson Cancer Center and Rigel Pharmaceuticals, Inc. today announced a multi-year strategic development collaboration to expand the evaluation of olutasidenib in acute myeloid leukemia (AML) and other hematologic cancers.

8 Dec 2023

Being Black and pregnant in the deep South can be a dangerous combination

O'laysha Davis was a few weeks shy of her due date when in mid-August she decided it was time to switch doctors.

8 Dec 2023

Key gene linked to male bias in autism, Tourette's, and ADHD uncovered

Sex bias in attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and Tourette syndrome (TS).

8 Dec 2023

Repeated mRNA vaccines supercharge immune response against COVID-19, study finds

Study published in Nature Immunology reveals that repeated mRNA COVID-19 vaccinations enhance immune response, especially in previously infected individuals, leading to a diversified and increased number of immune cell clones and a stronger ability to combat various virus strains.

7 Dec 2023

Syndrome News and Research

New combination treatment offers hope for older patients with mantle cell lymphoma

Synbiotic formula shows promise in reducing long COVID symptoms

Study finds tree nuts as snack alternative boost metabolic health in young adults

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

New SARS-CoV-2 variant JN.1 shows increased transmissibility and immune resistance

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

MD Anderson researchers report early success of novel menin-targeted therapies in leukemia

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Phase 2 trial data shows safety, tolerability and efficacy of imlifidase in GBS patients

COVID-19 significantly raises risk of severe complications in pregnant women

Study explores the intricate gut-brain-liver connection and its impact on health

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

Being Black and pregnant in the deep South can be a dangerous combination

Key gene linked to male bias in autism, Tourette's, and ADHD uncovered

Repeated mRNA vaccines supercharge immune response against COVID-19, study finds

Immunoregulatory nanomedicines for the prevention and treatment of respiratory diseases

Can oral contraceptive therapy improve the vaginal microbiome in women with PCOS?

The association between viral infections and glioma risk

Study links elevated BMI to weaker immune response post-SARS-CoV-2 infection

Irregular sleep patterns linked to cognitive decline in older adults, study shows

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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