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Reduced ovarian reserve is associated with an increased risk of trisomic pregnancy

Women who have a diminished number of eggs in their ovaries, either because they are older or for some other reason such as ovarian surgery, may be more at risk of a trisomic pregnancy than women with an ovarian reserve within the normal, fertile range.

30 Jun 2009

Two studies on polycystic ovarian syndrome shed light on its causes and its effect on brothers of women with the condition

Researchers have found evidence that chronic disease in either a mother or father can create unfavourable conditions in the womb that are associated with the development of polycystic ovarian syndrome (PCOS) in daughters. In another study, researchers found that brothers of women with PCOS and insulin resistance are themselves at greater risk of developing insulin resistance or diabetes, suggesting that factors associated with the condition can be passed down to sons as well as daughters.

30 Jun 2009

New pieces in the autism inheritance puzzle

Pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from the University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia (CHOP). The study identified 27 different genetic regions where rare copy number variations - missing or extra copies of DNA segments - were found in the genes of children with autism spectrum disorders, but not in the healthy controls. The findings are published June 26 in the open-access journal PLoS Genetics.

30 Jun 2009

Deep brain stimulation for psychiatric disorders

Pioneering therapeutic trials to investigate the effectiveness of deep brain stimulation (DBS) in hard-to-treat depression, obsessive-compulsive disorder (OCD) and Tourette's syndrome are underway at multiple medical centers around the world, according to a review in the June 2009 issue of Mayo Clinic Proceedings.

30 Jun 2009

Review of endocrine disorders in the U.S.

A dogged review of the medical literature has produced what is believed to be the nation's first comprehensive estimate of the extent of dozens of endocrine disorders in the United States.

29 Jun 2009

New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis

A new test examining chromosomes in human eggs a few hours after fertilisation can identify those that are capable of forming a healthy baby, a researcher told the 25th annual conference of the European Society of Human Reproduction and Embryology today (Monday 29 June).

29 Jun 2009

Heart attacks kill 10,000 Australians each year and many could be avoided

A new report by Access Economics has revealed that this year 80,000 Australians can expect to be treated in hospital for heart attacks or chest pain - at a cost to the economy of $18 billion and 10,000 people will die from a heart attack.

28 Jun 2009

ADHD genes found - missing DNA segments may suggest future drug targets

Pediatric researchers have identified hundreds of gene variations that occur more frequently in children with attention-deficit hyperactivity disorder (ADHD) than in children without ADHD. Many of those genes were already known to be important for learning, behavior, brain function and neurodevelopment, but had not been previously associated with ADHD.

24 Jun 2009

Measuring fragile X mental retardation

Researchers from the University of California, Davis have developed a specific and quantitative means of measuring levels of the fragile X mental retardation 1 (FMR1) protein (FMRP), which is mutated in fragile X syndrome. The related report by Iwahashi et al, "A quantitative ELISA assay for the fragile X mental retardation 1 protein," appears in the July 2009 issue of the Journal of Molecular Diagnostics.

24 Jun 2009

Scientists unearth the roots of human genetic variation

A new study at the University of Leicester is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans.

23 Jun 2009

Women warned not to wait too long to have a baby

Women are being warned that they should consider starting a family before the age of 35 or they will risk missing out on motherhood.

21 Jun 2009

HIV antibody tests unreliable for early infections in teens

A previously healthy teenager shows up at the doctor's office with a sore throat, fever, aches and general malaise. Routine blood tests are normal, an HIV test comes back negative, and the pediatrician sends the patient home with a diagnosis of acute viral infection.

21 Jun 2009

New theory for global diabetes epidemic

A new "fertility first" hypothesis published this week by a group of international experts in the American Journal of Human Biology, proposes that the global epidemic of Type 2 diabetes has its origins in the struggle, over millennia, to sustain human fertility in environments defined by famine.

19 Jun 2009

Marker in blood may explain susceptibility to interstitial cystitis

A marker in the blood of both cats and humans that was identified in a recent study might signal both species' susceptibility for a painful bladder disorder called interstitial cystitis, a condition that is often difficult to diagnose.

16 Jun 2009

High-tech approach to combat sepsis

When Jason Martin gives a talk about his research, he begins with the dramatic story of Mariana Bridi da Costa: The young Brazilian supermodel died from severe sepsis in January after amputation of both her hands and feet failed to stop its spread.

15 Jun 2009

Rhinosinusitis may be a factor in toxic shock syndrome in children

Rhinosinusitis (infection and inflammation in the sinus passages surrounding the nose) appears to be a primary factor in about one-fifth of toxic shock syndrome cases in children, according to a report in the June issue of Archives of Otolaryngology-Head & Neck Surgery.

15 Jun 2009

Inflammation of microglia may not be associated with dementia in Alzheimer's disease

The idea that anti-inflammatory drugs might protect people struggling with dementia from Alzheimer's disease has received a blow with the online release of a study of human brain tissue in Acta Neuropathologica.

15 Jun 2009

Don't stress when the going gets tough - you'll go gray!

A study by Japanese researchers has revealed that a certain kind of stress damages the hair - they say "genotoxic stress" damages DNA by depleting the melanocyte stem cells (MSCs) within hair follicles that are responsible for making the pigment-producing cells.

14 Jun 2009

Genotoxic stress makes your hair go gray

Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the June 12 issue of Cell, a Cell Press publication.

12 Jun 2009

Snoring during pregnancy may mean greater risk for gestational diabetes

If you are pregnant and your mate complains your frequent snoring is rattling the bedroom windows, you may have bigger problems than an annoyed, sleep-deprived partner.

12 Jun 2009