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Century old rule of chemistry overturned - major implications for drug delivery

A new study by research chemists at the University of Warwick has challenged a century old rule of pharmacology that defined how quickly key chemicals can pass across cell walls. The new observations of the Warwick researchers suggest that the real transport rates could be up to a hundred times slower than predicted by the century old "Overton's Rule". This could have major implications for the development and testing of many future drugs.

25 Aug 2008

NicOx updates on PF-03187207 and research collaboration with Pfizer

NicOx S.A. has announced the results of a dose-ranging phase 2 study conducted with PF‑03187207 in Japanese patients with glaucoma by its partner Pfizer Inc. PF-03187207 is a nitric oxide-donating prostaglandin analog. The study was designed to compare the safety and efficacy of several doses of PF-03187207 to Xalatan (latanoprost) and enrolled 112 Japanese patients with primary open-angle glaucoma or ocular hypertension.

25 Aug 2008

Study reveals how blood flow force protects against atherosclerosis

Machines on cell surfaces, mechanical and lifeless as bed springs, protect blood vessels by responding to blood flow force, according to research published today in the Journal of Cell Biology. By sensing and reacting to force, such machines interfere with inflammatory pathways central to atherosclerosis, the cause of clogged arteries that lead to heart attack and stroke, the authors said. The next set of studies, already underway, seeks to "tweak" the process with the goal of designing a new class of therapies.

25 Aug 2008

UT Southwestern scientists discover leptin can also aid type 1 diabetics

Terminally ill rodents with type 1 diabetes have been restored to full health with a single injection of a substance other than insulin by scientists at UT Southwestern Medical Center.

25 Aug 2008

Charity warns elderly still go hungry in hospital

A charity in Britain says elderly people are still going hungry on hospital wards and many hospitals are still not doing enough to ensure they are properly fed.

25 Aug 2008

Mosquitoes stay away from DEET because they hate the smell!

According to scientists in the U.S. the reason why the insect repellent DEET works so well is because mosquitoes don't like the smell.

25 Aug 2008

Daily aspirin recommended for all middle-aged

Researchers in the UK say that taking an aspirin each day could prevent heart attacks in middle-age.

25 Aug 2008

Sniffing out skin cancer by smell

According to researchers in the U.S. the smell skin gives off could indicate the presence of skin cancers. They say cancers such as basal cell carcinomas can be identified by the odour on the skin.

25 Aug 2008

Gene responsible for rare and inherited, deadly childhood cancer discovered

The discovery of a gene which causes a rare, inherited and deadly form of childhood cancer, could lead to new treatments for the disease.

25 Aug 2008

Good tidings for women on HRT

For many women struggling to deal with the symptoms of the menopause, the latest research on hormone replacement therapy (HRT) bears good tidings.

25 Aug 2008

FDA approves Nplate (romiplostim), first bone marrow stimulator for chronic immune thrombocytopenic purpura

The U.S. Food and Drug Administration has approved Nplate (romiplostim), the first product that directly stimulates the bone marrow to produce needed platelets in patients with a rare blood disorder that can lead to serious bleeding.

24 Aug 2008

Researchers discover key allergy gene

Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universitat Munchen, scientists at the Helmholtz Zentrum Munchen have pinpointed a major gene for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Munchen.

24 Aug 2008

Brain study could lead to new understanding of depression

Brain scientists have moved a step closer to understanding why some people may be more prone to depression than others.

From The University of Manchester 24 Aug 2008

Australia-PNG partnership wins major research grant to investigate tuberculosis in children

An Australia-Papua New Guinea research partnership that aims to develop a new diagnostic tool to quickly and accurately identify children with tuberculosis has been awarded a sought-after funding grant at the recent International AIDS Conference in Mexico City.

24 Aug 2008

Malaria researchers discover new mosquito virus

Researchers at the Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute have identified a previously unknown virus that is infectious to Anopheles gambiae-the mosquito primarily responsible for transmitting malaria.

24 Aug 2008

Computer modeling technology helps HIV treatment in developing nations

In the past 10 years, the global campaign to expand treatment for millions of people with AIDS living in resource-limited countries, especially in sub-Saharan Africa, has gained substantial commitments in public and private financing, and has made major strides in making treatment available to those who need it.

24 Aug 2008

New vaccine to fight multiple influenza strains

A universal vaccine effective against several strains of influenza has passed its first phase of testing, according to Dr. Christine Turley of the University of Texas at Galveston.

21 Aug 2008

Obesity in elderly creating a ticking time bomb for health services in developed countries

Research carried out at the Peninsula Medical School in the South West of England has discovered that obesity in later life does not make a substantial difference to risks of death among older people but that it is a major contributor to increased disability in later life - creating a ticking time bomb for health services in developed countries.

21 Aug 2008

Novel imaging reagents and technology that non-invasively locates, quantifies specific cells in the body

Magnetic resonance imaging (MRI) isn't just for capturing detailed images of the body's anatomy. Thanks to novel imaging reagents and technology developed by Carnegie Mellon University scientist Eric Ahrens, MRI can be used to visualize - with "exquisite" specificity - cell populations of interest in the living body. The ability to non-invasively locate and track cells, such as immune cells, will greatly aid the study and treatment of cancer, inflammation, and autoimmune diseases, as well as provide a tool for advancing clinical translation of the emerging field of cellular regenerative medicine, by tracking stem cells for example.

21 Aug 2008

Why hormone therapy for prostate cancer fails

Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.

21 Aug 2008