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Antidepressant amitriptyline shown to alleviate symptoms of irritable bowel syndrome

Researchers at Mattel Children's Hospital UCLA have found that low-dose antidepressant therapy can significantly improve the overall quality of life for adolescents suffering from irritable bowel syndrome (IBS).

1 May 2008

Breakthrough compound could lead to new class of antihypertensive drugs

University of Florida researchers have identified a drug compound that dramatically lowers blood pressure, improves heart function and - in a remarkable finding - prevents damage to the heart and kidneys in rats with persistent hypertension

1 May 2008

Short and long sleepers more likely to have metabolic syndrome

A study published in the May 1 issue of the journal SLEEP is the first known to report that short and long sleepers are more likely to have metabolic syndrome, or a combination of medical disorders that increase the risk of developing cardiovascular disease.

1 May 2008

Stanford researchers synthesize new agents to flush HIV out of hiding

Any hunter will tell you that when your quarry goes into hiding, you have to flush it out to get a good shot at it. Such is the case with HIV, the virus that causes AIDS.

1 May 2008

Phase of clock gene expression in human leukocytes correlates with habitual sleep timing

The phase of clock gene expression in leukocytes, assessed in the absence of the masking effects of light-dark and sleep-wake cycles, correlates with habitual sleep timing, according to a study published in the May 1 issue of the journal SLEEP.

1 May 2008

Novel automated anesthetic technique

Researchers at McGill University and the McGill University Health Centre (MUHC) have performed the world's first totally automated administration of an anesthetic. Nicknamed "McSleepy," the new system developed by the researchers administers drugs for general anesthesia and monitors their separate effects completely automatically, with no manual intervention.

1 May 2008

Children's experiences in a pediatric intensive care unit

Nearly one in three children admitted to pediatric intensive care will experience delusions or hallucinations, which put them at higher risk for post-traumatic stress symptoms, according to a new study of children's experiences in a pediatric intensive care unit (PICU).

1 May 2008

Obesity and heart failure risk

Heart specialists at Johns Hopkins and elsewhere report what is believed to be the first wide-scale evidence linking severe overweight to prolonged inflammation of heart tissue and the subsequent damage leading to failure of the body's blood-pumping organ.

1 May 2008

3M Drug Delivery System collaborates on vaccine adjuvants

3M Drug Delivery Systems announces the signing of a non-exclusive license agreement with the Infectious Disease Research Institute (IDRI) in support of vaccine research for humanitarian efforts in developing countries. Under the agreement, 3M will donate its patented toll-like receptor (TLR) immune response modifier compounds.

1 May 2008

New study raises questions about prostate cancer therapies targeting insulin-like growth factor receptor

Therapies under development to treat prostate cancer by inhibiting the ability of insulin-like growth factor (IGF-1) to activate its target receptor could have unexpected results especially if a major tumor suppressor gene - p53 - is already compromised, according to new research by investigators at Fred Hutchinson Cancer Research Center.

1 May 2008

Small molecule nutlin-3a activates an important cancer suppressor gene

By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health.

1 May 2008

Intensive training for medical staff in Latin American hospitals reduces serious complication of pregnancy

An intensive educational program for physicians and midwives involving 19 hospitals in Argentina and Uruguay dramatically reduced the rate of postpartum hemorrhage, according to researchers from the National Institutes of Health and other institutions.

1 May 2008

U-M receives grant to provide free and open, online health professions educational materials

The University of Michigan has launched an ambitious pilot project to make comprehensive pre-clinical health curricula available worldwide via the Internet.

1 May 2008

TV injury coverage lacking, study finds

Nearly every night, on nearly every TV station in the country, the local newscast features news of the day's car crashes, fires and other injury-causing events.

1 May 2008

High blood pressure still sneaking past doctors, Stanford study shows

Despite the well-known dangers of high blood pressure, major shortfalls still exist in the screening, treatment and control of the disease even when patients are getting a doctor's care, according to a study from the Stanford University School of Medicine.

1 May 2008

Dual treatment of incontinence and dementia associated with functional decline

Older nursing home residents who took medications for dementia and incontinence at the same time had a 50 percent faster decline in function than those who were being treated only for dementia, according to a study from researchers at Wake Forest University School of Medicine and colleagues.

1 May 2008

Scientists produce stem cells from ordinary mouse skin cells

Researchers in the United States say they have produced a stem cell made from ordinary mouse skin cells which they have coaxed into becoming three different types of heart and blood cells in mice.

1 May 2008

Cocaine addicts who use other substances have more mental health problems

A study carried out by Spanish scientists shows that cocaine users who take other addictive substances demonstrate a higher risk of mental health problems.

1 May 2008

Biomarker predicts malignancy potential of HG-PIN lesions in the prostate

Men whose prostate cancer screenings show high grade prostatic intraepithelial neoplasia (HG-PIN) may find themselves in limbo, "stuck" between diagnoses - they are told prostate cancer has not yet developed, but it might, and they are advised to undergo repeated needle biopsies as a precaution.

1 May 2008

Early treatment of Helicobacter pylori infection may prevent cancer

Based on research using a new mouse model of gastritis and stomach cancer, researchers from the Massachusetts Institute of Technology (MIT) say that prompt treatment of Helicobacter pylori (H. pylori) infections reverses damage to the lining of the stomach that can lead to cancer.

1 May 2008