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One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

The frequency of viral rebound (VR) among acute coronavirus disease 2019 patients.

16 Nov 2023

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.

15 Nov 2023

Longitudinal study elucidates mechanisms driving progression of neurodegenerative disorders

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, "Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model."

15 Nov 2023

Study sheds light on specific variants responsible for rare and serious disorder

Many disorders are caused by genetic variants; to make matters worse, the genetic origin of most disorders remains unknown.

15 Nov 2023

Cannabis shows promise in easing endometriosis pain, new research suggests

The Journal of Clinical Medicine review explores cannabis as a self-management strategy for endometriosis pain, revealing its potential to reduce gut inflammation and improve gut permeability, thereby alleviating bloating and suppressing pain through interactions with the endocannabinoid system and gut microbiota.

14 Nov 2023

Review sheds light on the complex challenge of diagnosing and managing cow's milk allergy in children

The Nutrients journal review highlights the challenges in diagnosing and managing Cow's Milk Allergy (CMA) in children, emphasizing the discrepancy between clinical guidelines and actual practice, and the need for improved strategies in prevention and management.

14 Nov 2023

New approach to CAR T cell therapy may extend treatment effectiveness

CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize and attack cancer cells.

14 Nov 2023

Alcohol consumption linked to accelerated biological aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Alcohol consumption and epigenetic age acceleration across human adulthood."

14 Nov 2023

New vaccine against Strep A could drastically cut antibiotic use for sore throats, study suggests

Study predicts that a vaccine against group A Streptococcus (Strep A) could significantly reduce antibiotic prescriptions for sore throat, potentially leading to a 33% decrease in global antibiotic use for this condition.

14 Nov 2023

Drinking coffee regularly may help prevent irritable bowel syndrome

Study reveals that coffee consumption is associated with a reduced risk of developing irritable bowel syndrome (IBS), as determined by a systematic review and meta-analysis of global studies.

14 Nov 2023

High-dose CBD fails to relieve pain in knee osteoarthritis patients

Cannabidiol (CBD) is marketed by some suppliers as a painkiller, e.g. for osteoarthritis of the knee. Animal experiments have shown that the substance, which is extracted from the hemp plant, has an anti-inflammatory and pain-relieving effect in arthritis.

14 Nov 2023

Placental inflammation's role in adult depression and heart disease

An expression signature related to inflammation expressed in Hofbauer cells in the placenta, calculating polygenic risk scores to predict its expression.

14 Nov 2023

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

The study in JAMA Network Open evaluates the effectiveness of simultaneously administering the Pfizer-BioNTech BNT162b2 BA.4/5 COVID-19 vaccine and seasonal influenza vaccines versus separate administration. Results suggest similar or slightly increased COVID-19 outcomes and lower influenza-related outcomes with coadministration, particularly in those aged 65 and above.

13 Nov 2023

Hospital-acquired COVID-19 mortality drops in Omicron era post-vaccination, reveals Swedish study

In a study published in JAMA Network Open, researchers found that hospital-acquired SARS-CoV-2 infections in Stockholm led to increased 30-day mortality in the pre-vaccination period but showed significantly lower mortality during the Omicron wave post-vaccination. The study underscores the importance of vaccination in reducing mortality risks from nosocomial SARS-CoV-2 infections.

13 Nov 2023

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

In a JAMA Network Open study, researchers found no evidence of neuroinflammation or blood-brain barrier dysfunction in cerebrospinal fluid markers of individuals with post-COVID-19 condition and neuropsychiatric symptoms compared to controls. The study, which assessed cytokines, chemokines, and neuroinflammation markers, suggests that persistent central nervous system immune activation may not be the primary driver of neurological long COVID symptoms.

13 Nov 2023

Initial high-risk antibody profile for antiphospholipid syndrome tends to remain high in pediatric patients, study finds

A new study by Hospital for Special Surgery (HSS) investigators has found that an initial high-risk antibody profile for antiphospholipid syndrome (APS) tended to remain high in pediatric patients.

13 Nov 2023

Revolutionizing critical care: the potential of gut microbiota therapeutics

The curative potential and limitations of gut microbiome-based therapeutics in critical illnesses.

13 Nov 2023

Food allergies may be linked to increased cardiovascular death risk, study finds

Sensitivity to common food allergens such as dairy and peanuts could be an important and previously unappreciated cause of heart disease, new research suggests – and the increased risk for cardiovascular death includes people without obvious food allergies.

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

In an Australian study published in EClinicalMedicine, researchers evaluated the impact of a combined genomic screening program for hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia in young adults. The program proved to be cost-effective, reducing healthcare costs and averting numerous health events, while emphasizing the need for further optimization and equitable access within public healthcare systems.

12 Nov 2023

Syndrome News and Research

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Longitudinal study elucidates mechanisms driving progression of neurodegenerative disorders

Study sheds light on specific variants responsible for rare and serious disorder

Cannabis shows promise in easing endometriosis pain, new research suggests

Review sheds light on the complex challenge of diagnosing and managing cow's milk allergy in children

New approach to CAR T cell therapy may extend treatment effectiveness

Alcohol consumption linked to accelerated biological aging

New vaccine against Strep A could drastically cut antibiotic use for sore throats, study suggests

Drinking coffee regularly may help prevent irritable bowel syndrome

High-dose CBD fails to relieve pain in knee osteoarthritis patients

Placental inflammation's role in adult depression and heart disease

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

Hospital-acquired COVID-19 mortality drops in Omicron era post-vaccination, reveals Swedish study

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

Initial high-risk antibody profile for antiphospholipid syndrome tends to remain high in pediatric patients, study finds

Revolutionizing critical care: the potential of gut microbiota therapeutics

Food allergies may be linked to increased cardiovascular death risk, study finds

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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