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Role of SARS-CoV-2 infection biomarkers in HIV replication

A new study investigates the role of the S100A8/A9 complex in the replication of HIV.

25 Oct 2021

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

Osteocalcin (OCN) is a multifunctional bone-derived hormone that modulates numerous physiological activities. OCN can cross the blood brain barrier (BBB) and thus play critical roles in neuronal and brain development.

25 Oct 2021

Honeybees can be trained to identify SARS-CoV-2 infected samples, say scientists

In a recent study published on the bioRxiv* pre-print server, researchers from the Netherlands successfully trained honeybees (Apis mellifera) to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected minks (Neovison vison) using Pavlovian conditioning protocols.

21 Oct 2021

Biomarker predicts severity of SARS-CoV-2 infection in patients

A new study investigates a biomarker to predict the severity of disease in patients infected with SARS-CoV-2.

20 Oct 2021

Two doses of Pfizer-BioNTech vaccine effective in preventing COVID-19 hospitalization among adolescents

The Centres for Disease Control and Prevention conducted a study to determine the vaccination efficacy in the adolescent population, published recently.

20 Oct 2021

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

Study highlights the critical role of junk DNA in mammalian development

Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or broken genes, viruses that got stuck in our genome and were dismembered or silenced, none of it relevant to the human organism or human evolution.

19 Oct 2021

Scientists scan 110 natural compounds for SARS-CoV-2 antiviral potential

Phytochemicals are plant-derived molecules from medicinal plants that act as a prominent reservoir for treating a wide range of viral infections. In a new study, published in the journal Scientific Reports, scientists adopted a computational approach to identify Mpro inhibitors.

19 Oct 2021

Study assesses T-cell responses directed against highly conserved regions of SARS-CoV-2

The study aimed to assess whether highly conserved regions within coronaviruses harbor CD8+ T-cell epitopes, capable of being cross-recognized between different coronaviruses.

18 Oct 2021

Inhibition of SARS-CoV-2 helicase by single DNA lesions

In a paper, the impact of specific DNA lesions is investigated regarding the unwinding activity of NSP13.

18 Oct 2021

Mothers pass on the legacy of stress exposure to future generations

A mother's response to stress can even influence her grandchildren. Biologists at the University of Iowa found that roundworm mothers subjected to heat stress passed, under certain conditions and through modifications to their genes, the legacy of that stress exposure not only to their offspring but even to their offspring's children.

13 Oct 2021

Study reveals the zoonotic potential of the rat Sialodacryoadenitis virus

A new review aimed to describe the current state of knowledge on Sialodacryoadenitis virus, along with its characteristics and potential zoonotic threat.

13 Oct 2021

Anti-rheumatic drug as a potential candidate for treating COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces inflammatory cytokine storms. But an FDA-approved anti-rheumatic drug, Auranofin, used to treat autoimmune and infectious diseases, may also help serve as an antiviral treatment for COVID-19 infection.

13 Oct 2021

Researchers find how iron deficient plants protect themselves from damaging light

Researchers have identified how iron deficient plants protect themselves from damaging light, according to a Dartmouth study.

13 Oct 2021

Comparing lateral flow testing with RT-PCR to detect SARS-CoV-2

Lateral flow devices (LFDs) are point-of-care tests that require significantly more time to develop than RT-PCR assays but can be used locally with minimal to no training, some of which can provide results in as little as 30 minutes. However, there have been some worries about the sensitivity of such kits. As a result, researchers from Micropathology Ltd have been comparing the two methods.

12 Oct 2021

Research elucidates how chaperones display "selective promiscuity" for specific proteins

A team of researchers at the University of Massachusetts Amherst has announced a major new advance in understanding how our genetic information eventually translates into functional proteins - one of the building blocks of human life.

12 Oct 2021

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Researchers in Germany have developed a promising approach to suppressing the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

12 Oct 2021

Single-genome sequencing reveals malaria parasite genetics and evolution

Understanding how malaria parasites evolve after a human is bitten by an infected mosquito is very difficult. There can be billions of individual parasites in a patient's bloodstream and traditional genetic sequencing techniques can't identify the raw material for evolution: new mutations.

12 Oct 2021

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Researchers review diverse computational methods for drug/inhibitor design and enzymes as potential targets for inhibitors to treat coronaviruses diseases.

12 Oct 2021

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new paper shows that human TLR3, TLR7, and TLR8 receptors are activated with naturally occurring RNA, but this is eliminated once modified nucleosides such as m5C, m6A, m5U s2U, or pseudouridine are incorporated.

12 Oct 2021

Transcription News and Research

Role of SARS-CoV-2 infection biomarkers in HIV replication

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

Honeybees can be trained to identify SARS-CoV-2 infected samples, say scientists

Biomarker predicts severity of SARS-CoV-2 infection in patients

Two doses of Pfizer-BioNTech vaccine effective in preventing COVID-19 hospitalization among adolescents

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

Study highlights the critical role of junk DNA in mammalian development

Scientists scan 110 natural compounds for SARS-CoV-2 antiviral potential

Study assesses T-cell responses directed against highly conserved regions of SARS-CoV-2

Inhibition of SARS-CoV-2 helicase by single DNA lesions

Mothers pass on the legacy of stress exposure to future generations

Study reveals the zoonotic potential of the rat Sialodacryoadenitis virus

Anti-rheumatic drug as a potential candidate for treating COVID-19

Researchers find how iron deficient plants protect themselves from damaging light

Comparing lateral flow testing with RT-PCR to detect SARS-CoV-2

Research elucidates how chaperones display "selective promiscuity" for specific proteins

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Single-genome sequencing reveals malaria parasite genetics and evolution

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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