Laboratory News and Research

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Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

13 Mar 2014

Knopp and NIAID collaborate to investigate eosinophil-lowering effects of dexpramipexole

Knopp Biosciences LLC today announced a second collaboration with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to investigate the eosinophil-lowering effects of the investigational drug dexpramipexole.

13 Mar 2014

New research raises hopes of new class of drugs to combat antibiotic resistant infections

New research has found some compounds effective in blocking the proliferation of certain bacteria, raising hopes of a new class of drugs to combat antibiotic resistant infections

13 Mar 2014

Two definitions of CMI symptoms should guide research and treatment of Gulf War veterans

Two existing definitions of chronic multisymptom illness (CMI) -- one by the Centers for Disease Control and Prevention and another from a study of Kansas Gulf War veterans -- should be used by the U.S. Department of Veterans Affairs to guide research and treatment of Gulf War veterans, says a new report from the Institute of Medicine.

13 Mar 2014

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear.

13 Mar 2014

Two synergistic therapies allow solid tumors to act as their own cancer-fighting vaccine

Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. These two synergistic therapies stimulate an immune response, ultimately allowing solid tumors to act as their own cancer-fighting vaccine.

13 Mar 2014

Duke-NUS researchers shed light on process that inhibits tumor development

A team of researchers from Duke-NUS Graduate Medical School have discovered a protein complex that disrupts the process known as dedifferentiation, known to promote tumor development.

13 Mar 2014

Researchers identify new player in onset and progression of heart failure

A team of cardiovascular researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai, Sanford-Burnham Medical Research Institute, and University of California, San Diego have identified a small, but powerful, new player in the onset and progression of heart failure.

13 Mar 2014

Blocking function of enzyme slows spread of pancreatic cancer, say researchers

A research team from Imperial College London has shown that blocking the function of an enzyme known as Hhat slows the growth and spread of pancreatic cancer, by preventing a protein called Hedgehog from stimulating nearby normal cells to help the cancer.

13 Mar 2014

Researchers to send 48 microbes to International Space Station

Microbes collected from Northern California and throughout the nation will soon blast into orbit for research and a microgravity growth competition on the International Space Station (ISS).

13 Mar 2014

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by University of Maryland School of Public Health researchers.

13 Mar 2014

EPFL sets up foundation to release antibiotic for tuberculosis

Even though tuberculosis kills more than 1.5 million people every year, the market is not cost-effective for pharmaceutical companies. So EPFL is setting up a foundation to release an antibiotic developed in its own laboratories under EU funding.

12 Mar 2014

Bone healing cells in non-smokers are of better quality than those of smokers

Bone healing cells in non-smokers are of a better quality, more active and quicker at dividing than those of smokers, according to new research.

12 Mar 2014

Three innovative tools to detect, test and initiate personalized drug treatment for seizures

A team of researchers from the National Institutes of Health, Emory University and Cedars-Sinai - specialists in identifying and treating very rare diseases - used three innovative tools to detect a previously unknown gene mutation, test potential therapies in the lab, and initiate personalized drug treatment for a boy with a lifelong history of uncontrollable seizures that caused significant impact on his cognitive and social development.

12 Mar 2014

Researchers explore how genetics affects causes and prevalence of preterm birth

More than 450,000 babies are born too soon each year in the U.S. Preterm birth is a serious health problem that costs the nation more than $26 billion annually, according to the Institute of Medicine, and is the leading cause of newborn death.

12 Mar 2014

Researchers find that brain cell regeneration may alleviate symptoms of Alzheimer's disease

Alzheimer's disease is the most widespread degenerative neurological disorder in the world. Over five million Americans live with it, and one in three senior citizens will die with the disease or a similar form of dementia. While memory loss is a common symptom of Alzheimer's, other behavioral manifestations - depression, loss of inhibition, delusions, agitation, anxiety, and aggression - can be even more challenging for victims and their families to live with.

12 Mar 2014

Researchers identify distinct profiles of brain activity present when making decisions

Although choosing to do something because the perceived benefit outweighs the financial cost is something people do daily, little is known about what happens in the brain when a person makes these kinds of decisions.

12 Mar 2014

Molecular substance that occurs naturally in humans reduces brain damage after acute stroke

A molecular substance that occurs naturally in humans and rats was found to "substantially reduce" brain damage after an acute stroke and contribute to a better recovery, according to a newly released animal study by researchers at Henry Ford Hospital.

12 Mar 2014

Sysmex America, Henry Schein sign three-year distribution agreement

Sysmex America, Inc., a global leader in medical diagnostic testing equipment and information systems technology, and Henry Schein, Inc., the world's largest provider of health care products and services to office-based dental, animal health and medical practitioners, today announced the signing of a three-year distribution agreement between the companies effective immediately.

From Sysmex America, Inc. 11 Mar 2014

Quest Diagnostics enters into definitive purchase agreement to acquire Summit Health

Quest Diagnostics, the world's leading provider of diagnostic information services, today announced that it has entered into a definitive purchase agreement under which Quest will acquire Summit Health.

From Quest Diagnostics 11 Mar 2014

Laboratory News and Research

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

Knopp and NIAID collaborate to investigate eosinophil-lowering effects of dexpramipexole

New research raises hopes of new class of drugs to combat antibiotic resistant infections

Two definitions of CMI symptoms should guide research and treatment of Gulf War veterans

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Two synergistic therapies allow solid tumors to act as their own cancer-fighting vaccine

Duke-NUS researchers shed light on process that inhibits tumor development

Researchers identify new player in onset and progression of heart failure

Blocking function of enzyme slows spread of pancreatic cancer, say researchers

Researchers to send 48 microbes to International Space Station

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

EPFL sets up foundation to release antibiotic for tuberculosis

Bone healing cells in non-smokers are of better quality than those of smokers

Three innovative tools to detect, test and initiate personalized drug treatment for seizures

Researchers explore how genetics affects causes and prevalence of preterm birth

Researchers find that brain cell regeneration may alleviate symptoms of Alzheimer's disease

Researchers identify distinct profiles of brain activity present when making decisions

Molecular substance that occurs naturally in humans reduces brain damage after acute stroke

Sysmex America, Henry Schein sign three-year distribution agreement

Quest Diagnostics enters into definitive purchase agreement to acquire Summit Health

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