Protein C News and Research

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Researchers find new role for SHARPIN protein in melanoma growth

Researchers at Sanford Burnham Prebys Medical Discovery and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex, regulating NFκB and other inflammatory molecules, SHARPIN modulates PRMT5, an epigenetic master switch that controls several proteins linked to melanoma. The research was published in The Journal of Clinical Investigation.

12 Dec 2017

Huntington's disease drug clears initial hurdles - raising hopes

Huntington’s disease is a genetic disorder that affects the brain progressively and has no known cure till date. In a breakthrough, the first drug that can target and reduce the cause behind this dreaded disease has been found to be effective, safe and well tolerated in a human clinical trial that was conducted by UCL scientists.

11 Dec 2017

Having older brothers may increase the likelihood of being gay

Scientists have found a distinct pattern that having older brothers raise the chances of the younger sibling being gay. This effect has been termed the “fraternal birth order effect”. They explain the biological reason behind this propensity in their new study that was published this week in the journal PNAS.

11 Dec 2017

Study: Combination targeted therapy has high response rates in AML patients

Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 percent patients say researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2017

Genentech researchers uncover epigenetic regulator of pancreatic cancer cells

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells' chromatin.

11 Dec 2017

Researchers uncover novel strategy to program immune system for fighting cancer

Looking to bolster the body's immune system in the fight against infection and cancer, researchers at the University of California San Diego and their colleagues have identified a promising new strategy to program the immune system to meet the pathogen or malignancy in the tissues where they first pose a threat.

11 Dec 2017

Study provides new insights into mechanism of tumor survival in glioblastoma

A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation therapy.

11 Dec 2017

Researchers discover potential regulator essential for killer T cells to reside in tumors

Researchers report the discovery that a protein called "Runx3" programs killer T cells to establish residence in tumors and infection sites.

11 Dec 2017

Scientists discover specific mechanism of Zika virus-associated microcephaly

Epidemiological studies show that in utero fetal infection with the Zika virus (ZIKV) may lead to microcephaly, an irreversible congenital malformation of the brain characterized by an incomplete development of the cerebral cortex.

11 Dec 2017

Russian researchers create new approaches to prevention and treatment of diabetes

A team of scientists from the Ural Federal University and the Institute of Immunology and Physiology modeled type 1 diabetes in an experiment to study recovery processes in the pancreas.

11 Dec 2017

New, more easily administered therapies offer benefits for bleeding and clotting disorders

In three studies being presented today during the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta, researchers report remarkable benefits from new, more easily administered therapies for bleeding and clotting disorders.

11 Dec 2017

Kidney dysfunction raises diabetes risk, study suggests

Diabetes is known to increase a person's risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes.

11 Dec 2017

Live-cell microscopy reveals internal forces that direct cell migration

Two new studies conducted at the Marine Biological Laboratory (MBL) indicate the way by which cells react to internal forces when they orient, gain traction, and migrate in a particular direction.

11 Dec 2017

Combination of chemotherapy and targeted drug improves response in younger CLL patients

Among younger patients newly diagnosed with chronic lymphocytic leukemia (CLL), treatment with a combination of chemotherapy and a molecularly targeted drug significantly improves response over what is typically seen with chemotherapy alone, according to an investigator-initiated multi-center phase II clinical trial.

11 Dec 2017

Breakthrough research could lead to development of yeast-based protein therapies

It took several years, but a research team headed by Professor Jens Nielsen at Chalmers University of Technology has finally succeeded in mapping out the complex metabolism of yeast cells.

11 Dec 2017

CAR T cell therapy shows long-lasting remissions in non-Hodgkin's lymphoma patients

In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah (formerly known as CTL019) demonstrated long-lasting remissions in non-Hodgkin's lymphoma (NHL) patients.

11 Dec 2017

Two immunotherapy approaches for multiple myeloma show hope

Researchers from the University of Pennsylvania's Abramson Cancer Center have developed two experimental immunotherapy methods that include one chimeric antigen receptor (CAR) T cell therapy for the treatment of multiple myeloma patients who were not responding to other treatments.

11 Dec 2017

Protein C News and Research

Researchers find new role for SHARPIN protein in melanoma growth

Huntington's disease drug clears initial hurdles - raising hopes

Having older brothers may increase the likelihood of being gay

Study: Combination targeted therapy has high response rates in AML patients

Genentech researchers uncover epigenetic regulator of pancreatic cancer cells

Researchers uncover novel strategy to program immune system for fighting cancer

Study provides new insights into mechanism of tumor survival in glioblastoma

Researchers discover potential regulator essential for killer T cells to reside in tumors

Scientists discover specific mechanism of Zika virus-associated microcephaly

Russian researchers create new approaches to prevention and treatment of diabetes

New, more easily administered therapies offer benefits for bleeding and clotting disorders

Kidney dysfunction raises diabetes risk, study suggests

Live-cell microscopy reveals internal forces that direct cell migration

Combination of chemotherapy and targeted drug improves response in younger CLL patients

Breakthrough research could lead to development of yeast-based protein therapies

CAR T cell therapy shows long-lasting remissions in non-Hodgkin's lymphoma patients

Two immunotherapy approaches for multiple myeloma show hope

Salk scientists unravel mystery about how the spinal cord deals with different information

Study estimates number of Americans with preclinical Alzheimer's or mild cognitive impairment

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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