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New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

A new study published in the journal Science Signaling on November 26, 2019, describes a mouse experiment, in which the immune response to the dengue vaccine was boosted when the mice were first given halofuginone, a plant compound that is well known to herbalists.

27 Nov 2019

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection.

26 Nov 2019

Newly discovered immune cells play key role in group A streptococcal toxic shock

Recently discovered immune cells called MAIT cells play a key role in group A streptococcal toxic shock, researchers at Karolinska Institutet in Sweden report.

25 Nov 2019

Yale study uncovers why belly fat surrounding organs increases as people age

A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation.

15 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

UAB study suggests potential treatment target for IPF

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair.

12 Nov 2019

Methotrexate reduces joint damage in hand osteoarthritis

A new study presented at the 2019 ACR/ARP meeting shows that methotrexate stopped further damage to the hand joints and even perhaps improved bone remodeling in patients with osteoarthritis (OA) of the hand, when they were assessed at 3 and 12 months.

11 Nov 2019

New textbook on mysterious and deadly cytokine storm syndrome

There's no telling where the call will come from, or when. But Randy Cron, M.D., Ph.D., professor of pediatrics and medicine at UAB, knows to expect them.

11 Nov 2019

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, methotrexate did not demonstrate superior efficacy over placebo for pain relief and function evolution at three and 12 months in patients with erosive hand osteoarthritis.

11 Nov 2019

Study shows ADA2 is a sensitive, specific biomarker for macrophage activation syndrome

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, adenosine deaminase 2 (ADA2) in the peripheral blood is a sensitive, specific biomarker for macrophage activation syndrome, a potentially life-threatening complication of systemic juvenile idiopathic arthritis (systemic JIA)

10 Nov 2019

Study: Pleural effusions are linked with NSCLC and malignant mesothelioma

Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system.

6 Nov 2019

MD Anderson and Takeda announce agreement to develop off-the-shelf CAR NK-cell therapy platform

The University of Texas MD Anderson Cancer Center and Takeda Pharmaceutical Company Limited today announced an exclusive license agreement and research agreement to develop cord blood-derived chimeric antigen receptor-directed natural killer (CAR NK)-cell therapies, 'armored' with IL-15, for the treatment of B-cell malignancies and other cancers.

5 Nov 2019

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

Granulocyte colony-stimulating factor, which causes division and differentiation of bone marrow cells depending on the body's need for leukocytes, has a significant regulatory effect not only on innate, but also on adaptive immunity.

31 Oct 2019

Early detection, treatment may reduce risk of death from systemic JIA-associated lung disease

For thousands of children living with the debilitating disease systemic juvenile idiopathic arthritis, a class of medications known as "biologics" have produced dramatic, life-changing improvements.

29 Oct 2019

Anti-inflammatory agents can safely, effectively reduce symptoms of major depression

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a pooled analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry.

29 Oct 2019

Pro-inflammatory protein could play key role in protecting against herpes virus

Researchers at the University of Arizona College of Medicine - Phoenix have discovered a function in a pro-inflammatory protein that could play an important part in improving current and future therapeutics for the herpes virus.

29 Oct 2019

Nerve cell protection without side effects on erythropoiesis

The hormone erythropoietin (Epo) is a well-known doping substance that has a long history of abuse in endurance sports, such as cycling. In addition to promoting red blood cell production (erythropoiesis), which improves the oxygen supply in the organism, Epo also protects nerve cells from cell death.

25 Oct 2019

Temple researchers win NIH grant to study HIV-related neuroinflammation in context of opioid addiction

The National Institutes of Health has awarded a Temple research team a 5-year, $3.27 million grant to study neuroinflammation following HIV-infection in the context of opioid addiction.

16 Oct 2019

Research reveals increased inflammatory activity in patients with frontotemporal dementia

Recent research from the University of Eastern Finland revealed increased inflammatory activity in a subgroup of patients with frontotemporal dementia. Increased inflammation was associated with parkinsonism symptoms and more rapid disease progression.

15 Oct 2019

Dysfunctions in blood vessels contribute to the development of chronic inflammatory bowel diseases

In Germany alone there are around 400,000 patients who suffer from chronic inflammatory bowel diseases. For the first time, researchers at Universitätsklinikum Erlangen have discovered that dysfunctions in blood vessels play a significant role in the development of such diseases.

9 Oct 2019

Cytokine News and Research

New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Newly discovered immune cells play key role in group A streptococcal toxic shock

Yale study uncovers why belly fat surrounding organs increases as people age

Research explains why immunotherapy fails against prostate cancer bone metastases

UAB study suggests potential treatment target for IPF

Methotrexate reduces joint damage in hand osteoarthritis

New textbook on mysterious and deadly cytokine storm syndrome

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Study shows ADA2 is a sensitive, specific biomarker for macrophage activation syndrome

Study: Pleural effusions are linked with NSCLC and malignant mesothelioma

MD Anderson and Takeda announce agreement to develop off-the-shelf CAR NK-cell therapy platform

Factor responsible for formation of white blood cells has regulatory effect on adaptive immunity

Early detection, treatment may reduce risk of death from systemic JIA-associated lung disease

Anti-inflammatory agents can safely, effectively reduce symptoms of major depression

Pro-inflammatory protein could play key role in protecting against herpes virus

Nerve cell protection without side effects on erythropoiesis

Temple researchers win NIH grant to study HIV-related neuroinflammation in context of opioid addiction

Research reveals increased inflammatory activity in patients with frontotemporal dementia

Dysfunctions in blood vessels contribute to the development of chronic inflammatory bowel diseases

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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