Laboratory News and Research

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Researchers identify important steps to understand mechanisms underlying pathogenic effect of prions

"When they are healthy, they look like tiny spheres; when they are malignant, they appear as cubes" stated Giuseppe Legname, principal investigator of the Prion Biology Laboratory at the Scuola Internazionale Superiore di Studi Avanzati (SISSA) in Trieste, when describing prion proteins.

25 Jan 2014

Clinical trial of experimental vaccine targets cancer stem cells in patients with recurrent brain tumor

An early-phase clinical trial of an experimental vaccine that targets cancer stem cells in patients with recurrent glioblastoma multiforme, the most common and aggressive malignant brain tumor, has been launched by researchers at Cedars-Sinai's Department of Neurosurgery, Johnnie L. Cochran, Jr. Brain Tumor Center and Department of Neurology.

25 Jan 2014

Scientists develop powerful RapidCaP mouse models for metastatic prostate cancer

Prostate cancer is the most common form of cancer in men. Affecting about 1 in 6 men, it is the second deadliest cancer. Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness.

25 Jan 2014

Aspirin intake correlates with halted growth of lethal intracranial tumor

Researchers from Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Institute of Technology and Massachusetts General Hospital have demonstrated, for the first time, that aspirin intake correlates with halted growth of vestibular schwannomas (also known as acoustic neuromas), a sometimes lethal intracranial tumor that typically causes hearing loss and tinnitus.

24 Jan 2014

Scientists aim to develop business plan to guide drug development for potential use in patients

What if an experimental treatment for an aggressive breast cancer had the potential to save women's lives, but nobody could use it because there was no money to develop and test it? With funding sources for research and development more scarce than in the past, it is not an unusual situation. It's a problem that Sourav Sinha, a Master's degree candidate at Rutgers' Graduate School of Biomedical Sciences, is working to tackle head-on.

24 Jan 2014

Researchers reveal how genetic susceptibility plays large role in cancer risk

In laboratory experiments conducted on human cell lines at the Johns Hopkins Kimmel Cancer Center, scientists have shown that people carrying certain mutations in two hereditary cancer genes, BRCA2 and PALB2, may have a higher than usual susceptibility to DNA damage caused by a byproduct of alcohol, called acetaldehyde.

24 Jan 2014

Omega-3 fatty acids especially DHA may have even wider range of biological impacts, shows study

A study of the metabolic effects of omega-3 fatty acids, especially DHA, concludes that these compounds may have an even wider range of biological impacts than previously considered, and suggests they could be of significant value in the prevention of fatty liver disease.

24 Jan 2014

Scientists identify molecules that block accumulation of toxic eye protein responsible for early onset of glaucoma

Using a novel high-throughput screening process, scientists have for the first time identified molecules with the potential to block the accumulation of a toxic eye protein that can lead to early onset of glaucoma.

24 Jan 2014

Study suggests potential therapeutic role of aspirin in inhibiting vestibular schwannoma growth

24 Jan 2014

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice. The stem cells, derived from human umbilical cord-blood and coaxed into an embryonic-like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

24 Jan 2014

BRI receives grant to lead ITN for evaluating novel therapies for transplantation, allergy and autoimmune diseases

The National Institutes of Health has awarded Benaroya Research Institute at Virginia Mason a 7-year grant to lead the Immune Tolerance Network.

24 Jan 2014

Loyola professor receives prestigious Presidential Early Career Award for Scientists and Engineers

Katherine Radek, PhD, of Loyola University Chicago Stritch School of Medicine, has received a prestigious Presidential Early Career Award for Scientists and Engineers.

24 Jan 2014

Human body odor contains an early chemosensory cue of sickness

Humans are able to smell sickness in someone whose immune system is highly active within just a few hours of exposure to a toxin, according to new research published in Psychological Science, a journal of the Association for Psychological Science.

24 Jan 2014

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.

23 Jan 2014

ACM Global acquires Phoenix PCS to expand operation in the Asia Pacific region

ACM Global Central Laboratory, a diagnostic central laboratory specializing in delivering high quality testing services which optimize clinical trial outcomes, today announced it has acquired Phoenix Pharma Central Services Pte. Ltd, a premier central laboratory services provider for Asia Pacific clinical trials, with laboratory facilities in Singapore and Shanghai, China. The acquisition enables ACM Global to deliver increased operational and financial efficiencies to clients conducting clinical studies in the Asia Pacific region. Terms of the transaction were not disclosed.

23 Jan 2014

Compact liquid handling workstation for PCR launched by Hamilton Robotics

At the annual Society for Laboratory Automation and Screening (SLAS) conference, Hamilton Robotics has introduces the NIMBUS® PCR Workstation, which is a compact and affordable pipetting workstation enabling fast and flexible assay setup for endpoint, real-time, qPCR or multiplex PCR.

23 Jan 2014

People with higher levels of omega-3 fatty acids may have larger brain volumes in old age

People with higher levels of the omega-3 fatty acids found in fish oil may also have larger brain volumes in old age equivalent to preserving one to two years of brain health, according to a study published in the January 22, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology. Shrinking brain volume is a sign of Alzheimer's disease as well as normal aging.

23 Jan 2014

ACMG’s Genomics Annual Clinical Genetics Meeting showcases latest breakthroughs in genetics research

Do you cover genetics, genomics, healthcare or medicine? The media are invited to register now for the American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting, March 25-29, 2014 at the Nashville Convention Center.

23 Jan 2014

Rice University-based research develops fast biosensor for pathogens in food

An array of tiny diving boards can perform the Olympian feat of identifying many strains of salmonella at once.

23 Jan 2014

New heart tissue could help patients suffering from irreparable damage

In the U.S., someone suffers a heart attack every 34 seconds - their heart is starved of oxygen and suffers irreparable damage. Engineering new heart tissue in the laboratory that could eventually be implanted into patients could help, and scientists are reporting a promising approach tested with rat cells.

23 Jan 2014

Laboratory News and Research

Researchers identify important steps to understand mechanisms underlying pathogenic effect of prions

Clinical trial of experimental vaccine targets cancer stem cells in patients with recurrent brain tumor

Scientists develop powerful RapidCaP mouse models for metastatic prostate cancer

Aspirin intake correlates with halted growth of lethal intracranial tumor

Scientists aim to develop business plan to guide drug development for potential use in patients

Researchers reveal how genetic susceptibility plays large role in cancer risk

Omega-3 fatty acids especially DHA may have even wider range of biological impacts, shows study

Scientists identify molecules that block accumulation of toxic eye protein responsible for early onset of glaucoma

Study suggests potential therapeutic role of aspirin in inhibiting vestibular schwannoma growth

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

BRI receives grant to lead ITN for evaluating novel therapies for transplantation, allergy and autoimmune diseases

Loyola professor receives prestigious Presidential Early Career Award for Scientists and Engineers

Human body odor contains an early chemosensory cue of sickness

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

ACM Global acquires Phoenix PCS to expand operation in the Asia Pacific region

Compact liquid handling workstation for PCR launched by Hamilton Robotics

People with higher levels of omega-3 fatty acids may have larger brain volumes in old age

ACMG’s Genomics Annual Clinical Genetics Meeting showcases latest breakthroughs in genetics research

Rice University-based research develops fast biosensor for pathogens in food

New heart tissue could help patients suffering from irreparable damage

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