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Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Subgroups of tuberculosis (TB)-causing bacteria can persist even when antibiotics wipe out most of the overall population. The need to eliminate these persistent subpopulations is one reason why TB treatment regimens are so lengthy.

1 Jun 2017

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

A phase 2 clinical trial in young adults with Down syndrome of a drug being investigated for the treatment of Alzheimer's disease supports further investigation of its potential.

1 Jun 2017

Researchers discover molecular signaling circuit that regulates autophagy

Autophagy is the recycling process by which our cells keep themselves young. They continually break down and renew small parts of themselves in a kind of self-digestion; this helps to counteract harmful deposits which may form.

1 Jun 2017

TSRI professor receives $2 million grant to study neurofibromatosis type I

Assistant Professor Seth Tomchik of the Florida campus of The Scripps Research Institute (TSRI) has received $2 million in funding from the National Institutes of Health's National Institute of Neurological Disorders and Stroke.

31 May 2017

Collaborative effort to develop rare disease patient registries

The Orphan Disease Center in the Perelman School of Medicine at the University of Pennsylvania will collaborate with Pulse Infoframe Inc., a medical informatics company, to develop rare disease patient registries aimed at enabling international collaboration to better understand these diseases, as well as accelerate and improve clinical studies to develop new therapies.

31 May 2017

Therapeutic small molecules safely prevent blood clots without excessive bleeding

It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications.

31 May 2017

Cognitive tests can detect early Alzheimer's in people without symptoms, study suggests

Long before symptoms of Alzheimer's disease become apparent to patients and their families, biological changes are occurring within the brain. Amyloid plaques, which are clusters of protein fragments, along with tangles of protein known as tau, form in the brain and grow in number, eventually getting in the way of the brain's ability to function.

31 May 2017

Novel vaccine therapy can generate immune responses in patients with HPV-related head and neck cancer

A novel vaccine therapy can generate immune responses in patients with head and neck squamous cell carcinoma (HNSCCa), according to researchers at the Abramson Cancer Center of the University of Pennsylvania.

31 May 2017

Cancer treatment may be effective therapy for psoriasis

HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report.

31 May 2017

Clinical trial uses small molecule to treat men with incurable prostate cancer

NewYork-Presbyterian and Weill Cornell Medicine have begun the first clinical trial in the United States that uses a small molecule to treat men with progressive prostate cancer that has spread beyond the prostate and is no longer responding to hormonal therapy.

31 May 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

Radboudumc, iMM Lisboa, PATH team up to test new malaria vaccine concept

The Radboud University Medical Center in the Netherlands, the Instituto de Medicina Molecular Lisboa in Portugal, and PATH in Seattle, Washington announced today that they will collaborate to test a new approach to malaria vaccine development in humans for the first time.

31 May 2017

Small clinical trial reveals promising results of triple immunotherapy in treating rare skin cancer

Three out of four patients treated with an experimental combination of three different therapies for the rare skin cancer known as Merkel cell carcinoma are in complete remission following the treatment, according to study results from a small clinical trial led at Fred Hutchinson Cancer Research Center.

31 May 2017

Common, inexpensive chemical could slow aging of human skin, research suggests

New work from the University of Maryland suggests that a common, inexpensive and safe chemical could slow the aging of human skin.

31 May 2017

CRISPR may not be as foolproof as earlier believed – gene editing tech leads to unwanted mutations

CRISPR-Cas9 is a revolutionary new gene-editing technology that has been called “molecular scissors” and has been one of the handiest tools for genetic engineers in the recent times. It makes cutting and pasting gene sequences almost as easy as it sounds. CRISPR has been hailed as a breakthrough in genetic engineering.

30 May 2017

Protein C News and Research

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Phase 2 clinical study examines Alzheimer's disease drug to treat adults with Down syndrome

Researchers discover molecular signaling circuit that regulates autophagy

TSRI professor receives $2 million grant to study neurofibromatosis type I

Collaborative effort to develop rare disease patient registries

Therapeutic small molecules safely prevent blood clots without excessive bleeding

Cognitive tests can detect early Alzheimer's in people without symptoms, study suggests

Novel vaccine therapy can generate immune responses in patients with HPV-related head and neck cancer

Cancer treatment may be effective therapy for psoriasis

Clinical trial uses small molecule to treat men with incurable prostate cancer

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Radboudumc, iMM Lisboa, PATH team up to test new malaria vaccine concept

Small clinical trial reveals promising results of triple immunotherapy in treating rare skin cancer

Common, inexpensive chemical could slow aging of human skin, research suggests

CRISPR may not be as foolproof as earlier believed – gene editing tech leads to unwanted mutations

Radiopharmaceutical for cancer diagnosis is ready for preclinical-phase trial

Kyoto University researchers identify specific gene as key regulator in iron uptake

Researchers develop new mouse model that could lead to better treatment of kidney cancer

Visual cortex of the brain develops gradually throughout life, study reveals

UT scientists develop glass microchip for ultrafast separation, purification of DNA fragments

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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