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Developing enhanced personalized cancer vaccines

Therapeutic cancer vaccines were first developed 100 years ago and have remained broadly ineffective to date. Before tangible results can be achieved, two major obstacles must be overcome.

11 Feb 2020

Braincool completes patient recruitment to study Cooral System for prevention of Oral Mucositis

BrainCool AB, a Swedish medical device innovator, and a world leader in medical cooling technology for therapeutic hypothermia (brain cooling) and oncology, is pleased to announce that it has completed patient recruitment in the Scandinavian multi-center pivotal trial of 180 patients to investigate the patented Cooral® System for prevention of Oral Mucositis, one of the most debilitating side-effects of both standard and high-dose chemotherapeutic oncology treatments.

11 Feb 2020

Blood test for inflammatory and cell senescence biomarkers may help predict cognitive decline

In order to provide the best medical care for newly diagnosed Parkinson's disease (PD) patients, a method of predicting their cognitive and motor progression, beyond using purely clinical parameters, would have major implications for their management.

11 Feb 2020

New multiplexed electrical biosensor for accurate detection of Alzheimer's disease

A research team at KAIST reported clinically accurate multiplexed electrical biosensor for detecting Alzheimer's disease by measuring its core biomarkers using densely aligned carbon nanotubes.

11 Feb 2020

Biological age metric can provide new opportunities for preventative healthcare

People age in different ways. Biological age is a metric that scientists use to predict health risks, the relevance of which can be enhanced by combining different markers. Particularly important markers are frailty and the epigenetic clock, write researchers from Karolinska Institutet in a study published in eLife.

11 Feb 2020

Free radicals from immune cells linked to salt-sensitive hypertension

In salt-sensitive hypertension, immune cells gather in the kidneys and shoot out free radicals, heightening blood pressure and damaging this pair of vital organs, scientists report.

11 Feb 2020

Better than other plans or better than nothing? Trump’s claim about ‘affordable’ options

In his wide-ranging State of the Union address, President Donald Trump returned to a favorite theme: the cost of health insurance.

11 Feb 2020

Western diet rich in fat and sugar may lead to inflammatory skin diseases

A Western diet rich in fat and sugar may lead to inflammatory skin diseases such as psoriasis, a study by UC Davis Health researchers has found.

10 Feb 2020

Depression treatment using AI, brain scans

Artificial intelligence (AI) may be a useful and even essential tool in selecting the best treatment for depression, according to a new study published in the journal Nature Biotechnology on February 2020.

10 Feb 2020

Finding the origins of angiosarcoma

In a new study published in the journal Nature Medicine on February 2020, scientists report some newly discovered reasons for the occurrence of a rare blood vessel wall cancer called angiosarcoma. This could one day help develop better therapies for this aggressive tumor. The project is a striking example of unexpectedly rich findings from a crowd-sourced venture that brings together a scattered group of patients with a rare disease.

10 Feb 2020

Novel method to spot melanoma may save lives

A new method to detect melanoma cancer cells circulating in the blood may be the key to detecting deadly cancer early and saving lives, a new study says.

10 Feb 2020

Researchers culture human blood-brain barrier on a chip

A scrupulous gatekeeper stands between the brain and its circulatory system to let in the good and keep out the bad, but this porter, called the blood-brain barrier, also blocks trial drugs to treat diseases like Alzheimer's or cancer from getting into the brain.

10 Feb 2020

Human textiles to replace damaged blood vessels

What if we could replace a patient's damaged blood vessels with brand new ones produced in a laboratory? This is the challenge set by Inserm researcher Nicolas L'Heureux, who is working on the human extracellular matrix - the structural support of human tissues that is found around practically all of the body's cells.

10 Feb 2020

Migraine sufferers appear to have hyper-excitable visual cortex, study suggests

Individuals who suffer from migraine headaches appear to have a hyper-excitable visual cortex researchers at the Universities of Birmingham and Lancaster suggest.

10 Feb 2020

Clinical trial of two investigational drugs for rare, inherited Alzheimer's yields disappointing results

An international clinical trial evaluating whether two investigational drugs can slow memory loss and cognitive decline in people in the early stages of a rare, inherited form of Alzheimer's disease has yielded disappointing results, an initial analysis of the data has shown.

10 Feb 2020

Youth with HIV have lower rates of viral suppression than adults

Despite similar rates of enrollment into medical care, youth with HIV have much lower rates of viral suppression--reducing HIV to undetectable levels--compared to adults, according to an analysis funded by the National Institutes of Health.

10 Feb 2020

Common drug could mitigate risk of 'a broken heart' during bereavement

The increased risk of heart attack or "a broken heart" in early bereavement could be reduced by using common medication in a novel way, according to a world-first study led by the University of Sydney and funded by Heart Research Australia.

10 Feb 2020

Higher maternal blood pressure linked to placental gene modifications

Higher maternal blood pressure in pregnancy is associated with chemical modifications to placental genes, according to a study by researchers from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health.

10 Feb 2020

Study uncovers new avenue for melanoma diagnosis and therapies

A new way to spot melanoma cells circulating in the blood has the potential to significantly improve the monitoring of cancer patients and guide future treatment.

10 Feb 2020

Research reveals novel way to treat cancers using CAR T cell therapy

Too many patients with cancers like multiple myeloma relapse after treatment. This grim reality motivated researchers at Huntsman Cancer Institute at the University of Utah to try to improve the depth and durability of treatment response in multiple myeloma through a new cancer cell targeting mechanism.

10 Feb 2020