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Antibodies boost immune system to fight childhood cancer, shows study

Researchers in the Antibody and Vaccine Group have developed two monoclonal antibodies (mAbs) called anti-4-1BB and anti-CD40 and investigated a third called anti-CTLA-4. Each of these antibodies binds to a different target molecule in the immune system, potentially heightening the body's own immune response to cancer.

12 Jul 2013

Scientists set out to develop safer versions of acetaminophen

Efforts to develop a safer form of acetaminophen - the pain and fever-reducer that is one of the most widely used drugs - have led to discovery of substances that may have less potentially toxic effects on the liver. A report on the research appears in ACS Medicinal Chemistry Letters.

12 Jul 2013

3D-printed airway splint saves life of infant born with severe tracheobronchomalacia

Half a millennium after Johannes Gutenberg printed the bible, researchers printed a 3D splint that saved the life of an infant born with severe tracheobronchomalacia, a birth defect that causes the airway to collapse.

12 Jul 2013

Global recruitment drive to bring best cancer experts to Manchester now underway

A global recruitment drive to bring 20 of the world's best cancer experts and their teams to Manchester, in the United Kingdom, is now underway.

From The University of Manchester 12 Jul 2013

Alnylam releases positive top-line data from ALN-TTRsc Phase I trial for TTR-mediated amyloidosis

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today positive top-line results from its ongoing Phase I trial of ALN-TTRsc, a subcutaneously administered RNAi therapeutic targeting the transthyretin gene for the treatment of TTR-mediated amyloidosis.

12 Jul 2013

Protein that triggers blood clotting plays critical role in growth of pancreatic and breast cancer

A recently discovered form of the protein that triggers blood clotting plays a critical role in promoting the growth of metastatic pancreatic cancer and primary breast cancer, according to the cumulative findings from two new scientific manuscripts published online ahead of print in the International Journal of Cancer and PNAS (Proceedings of the National Academy of Sciences).

12 Jul 2013

Researchers identify receptor mutation that blocked estrogen action in young woman

A receptor mutation that essentially blocks estrogen's action has been identified for the first time a female, researchers report.

12 Jul 2013

Research opens door to better understanding of inner-ear development process, potential treatments

Indiana University scientists have transformed mouse embryonic stem cells into key structures of the inner ear. The discovery provides new insights into the sensory organ's developmental process and sets the stage for laboratory models of disease, drug discovery and potential treatments for hearing loss and balance disorders.

12 Jul 2013

UIC researchers help minority patients to manage their health with common blood thinner

Minority patients trying to self-manage their health with the blood-thinning drug warfarin face difficulties, and researchers at the University of Illinois at Chicago College of Pharmacy are trying to help overcome them.

12 Jul 2013

New discovery may help doctors determine role of microchimerism in human diseases

Some people possess a small number of cells in their bodies that are not genetically their own; this condition is known as microchimerism. It is difficult to determine potential health effects from this condition because of humans' relatively long life-spans.

12 Jul 2013

New report says most psychological intervention studies do not account for placebo effect

Many brain-training companies tout the scientific backing of their products - the laboratory studies that reveal how their programs improve your brainpower. But according to a new report, most intervention studies like these have a critical flaw: They do not adequately account for the placebo effect.

12 Jul 2013

MDPV stimulant effects could be more addictive than methamphetamine, say TSRI researchers

Scientists at The Scripps Research Institute have published one of the first laboratory studies of MDPV, an emerging recreational drug that has been sold as “bath salts.”

11 Jul 2013

Scientists discover bacterium that stores biodegradable plastic

In Bolivia, in the largest continuous salt desert in the world, researchers from the Polytechnic University of Catalonia have found a bacterium that stores large amounts of PHB, a prized polymer. This biodegradable plastic is used by the food and pharmaceutical industries, for example to produce nanospheres to transport antibiotics.

11 Jul 2013

Study shows cigarette smoke inhibits activity of key genes that protect heart and lungs

New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage.

11 Jul 2013

Protein used by cancer cells also plays a vital role in heart health

St. Jude Children's Research Hospital scientists have discovered that a protein used by cancer cells to evade death also plays a vital role in heart health. This dual role complicates efforts to develop cancer drugs that target the protein, but may lead to new therapies for heart muscle damage. The research appeared in the June 15 edition of the scientific journal Genes & Development.

11 Jul 2013

Researchers confirm that bath salts could be more addictive than methamphetamine

Scientists at The Scripps Research Institute (TSRI) have published one of the first laboratory studies of MDPV, an emerging recreational drug that has been sold as "bath salts." The TSRI researchers confirmed the drug's powerful stimulant effects in rats and found evidence that it could be more addictive than methamphetamine, one of the most addictive substances to date.

11 Jul 2013

NIH awards Shared Instrumentation Grant to install 3D X-ray microscope at Creighton University

The National Institutes of Health (NIH) have awarded Mohammed Akhter, Ph.D., P.E., professor of medicine at Creighton University School of Medicine and director of the biomechanics laboratory at the Osteoporosis Research Center, a nearly $600,000 Shared Instrumentation Grant to install the area's first high-resolution 3D X-ray Microscope, the Xradia MicroXCT-200.

11 Jul 2013

YES workshop for adolescents to manage stress and control impulsive behavior

In May 2013, the Los Angeles school board voted to ban suspensions of students for "willful defiance" and directed school officials to use alternative disciplinary practices. The decision was controversial, and the question remains: How do you discipline rowdy students and keep them in the classroom while still being fair to other kids who want to learn?

11 Jul 2013

IDSA and ASM collaborate to guide the best use of lab tests for diagnosis of infectious diseases

A new guide developed by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM) will help physicians appropriately and accurately use laboratory tests for the diagnosis of infectious diseases. Laboratory test results drive approximately two-thirds of physicians' medical decisions.

11 Jul 2013

Study identifies new groups of people at risk of parasitic lung infection

A study conducted by Dr. James Diaz, Professor of Public Health and Preventive Medicine and Program Director of the Environmental/Occupational Health Sciences Program at the LSU Health Sciences Center New Orleans School of Public Health, analyzed cases of a parasitic lung infection and found new modes of transmission and associated behaviors, identifying new groups of people at risk.

11 Jul 2013

Laboratory News and Research

Antibodies boost immune system to fight childhood cancer, shows study

Scientists set out to develop safer versions of acetaminophen

3D-printed airway splint saves life of infant born with severe tracheobronchomalacia

Global recruitment drive to bring best cancer experts to Manchester now underway

Alnylam releases positive top-line data from ALN-TTRsc Phase I trial for TTR-mediated amyloidosis

Protein that triggers blood clotting plays critical role in growth of pancreatic and breast cancer

Researchers identify receptor mutation that blocked estrogen action in young woman

Research opens door to better understanding of inner-ear development process, potential treatments

UIC researchers help minority patients to manage their health with common blood thinner

New discovery may help doctors determine role of microchimerism in human diseases

New report says most psychological intervention studies do not account for placebo effect

MDPV stimulant effects could be more addictive than methamphetamine, say TSRI researchers

Scientists discover bacterium that stores biodegradable plastic

Study shows cigarette smoke inhibits activity of key genes that protect heart and lungs

Protein used by cancer cells also plays a vital role in heart health

Researchers confirm that bath salts could be more addictive than methamphetamine

NIH awards Shared Instrumentation Grant to install 3D X-ray microscope at Creighton University

YES workshop for adolescents to manage stress and control impulsive behavior

IDSA and ASM collaborate to guide the best use of lab tests for diagnosis of infectious diseases

Study identifies new groups of people at risk of parasitic lung infection

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