Protein C News and Research

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Study provides new understanding of molecular mechanisms that impact intellectual disability

Scientists from the Florida campus of The Scripps Research Institute have shown that a protein helps balance nerve cell communication.

25 Apr 2017

Research findings shed light on brain’s ability to make split-second decisions

When animals hunt or forage for food, they must constantly weigh whether the chance of a meal is worth the risk of being spotted by a predator. The same conflict between cost and benefit is at the heart of many of the decisions humans make on a daily basis.

25 Apr 2017

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Imagine this scenario on a highway: A driver starts to make a sudden lane change but realizes his mistake and quickly veers back, too late. Other motorists have already reacted and, in some cases, collide. Meanwhile, the original motorist - the one who caused the problem - drives on.

25 Apr 2017

Low levels of NPTX2 protein in the brain may lead to learning and memory loss in Alzheimer's disease

Working with human brain tissue samples and genetically engineered mice, Johns Hopkins Medicine researchers together with colleagues at the National Institutes of Health, the University of California San Diego Shiley-Marcos Alzheimer's Disease Research Center, Columbia University, and the Institute for Basic Research in Staten Island say that consequences of low levels of the protein NPTX2 in the brains of people with Alzheimer's disease (AD) may change the pattern of neural activity in ways that lead to the learning and memory loss that are hallmarks of the disease.

25 Apr 2017

Novel mechanism of antidepressant action may benefit patients unresponsive to SSRI treatment

Antidepressants treat symptoms of depression by increasing levels of brain signaling molecules such as serotonin, as with the most widely used type of antidepressant, selective serotonin reuptake inhibitors.

25 Apr 2017

Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

Cellular therapy hasn't had much success in fighting solid tumors, partly because it's been difficult to deliver anti-cancer T cells to the tumors.

25 Apr 2017

Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers

Whole-exome DNA sequencing -- a technology that saves time and money by sequencing only protein-coding regions and not the entire genome -- may routinely miss detecting some genetic variations associated with disease, according to Penn State researchers who have developed new ways to identify such omissions.

24 Apr 2017

UTSW researchers develop new nanoparticle vaccine immunotherapy that targets multiple tumor types

Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types.

24 Apr 2017

Scientists receive $2.8 million federal grant for diabetic cardiomyopathy research

Researchers from Georgia State University's Center for Molecular & Translational Medicine have received a four-year, $2.8 million federal grant to study diabetic cardiomyopathy, diabetes-related changes in the structure and function of the heart muscle.

24 Apr 2017

Researchers discover gene that may play role in restoring hearing after noise exposure

Researchers have discovered that a protein implicated in human longevity may also play a role in restoring hearing after noise exposure. The findings, where were published in the journal Scientific Reports, could one day provide researchers with new tools to prevent hearing loss.

24 Apr 2017

Synchronized voltage rhythms in SCN could play role in maintaining the body’s circadian clock

Cells in the brain's master circadian clock synchronize voltage rhythms despite asynchronous calcium rhythms, which might explain how a tissue-wide rhythm is maintained.

24 Apr 2017

Tiny silica 'cages' could help store and transport vaccines without refrigeration

Vaccines and antibodies could be transported and stored without refrigeration by capturing them in tiny silica 'cages', a discovery which could make getting vital medicines to remote or dangerous places much easier, cheaper and safer.

24 Apr 2017

Researchers discover new cellular mechanism that may cause multiple sclerosis

A new study has made a major new discovery towards finding the cause of multiple sclerosis (MS), potentially paving the way for research to investigate new treatments.

24 Apr 2017

Testing for molecular markers in urine could reveal early signs of kidney transplant failure

Testing for molecular markers in the urine of kidney transplant patients could reveal whether the transplant is failing and why, according to research presented at the 27th European Congress of Clinical Microbiology and Infectious Diseases.

24 Apr 2017

Transgenic fruit flies can shed light on genetic mutations that underlie kidney disease in humans

An off-the-shelf dietary supplement available for pennies per dose demonstrated the ability to reverse cellular damage linked to specific genetic mutations in transgenic fruit flies, an experimental model of genetic mutation-induced renal cell injury that features striking similarities to humans, a Children's National Health System research team reports April 20 in Journal of the American Society of Nephrology.

21 Apr 2017

Researchers show how fish oil component helps in survival of injured retina, brain cells

A team of researchers led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, has shown for the first time that NDP1, a signaling molecule made from DHA, can trigger the production of a protective protein against toxic free radicals and injury in the brain and retina.

21 Apr 2017

Global Kidney Health Atlas highlights huge gaps in CKD care and prevention

Despite one in 10 people worldwide having chronic kidney disease, a new global report - The Global Kidney Health Atlas - presented at this week's World Congress of Nephrology in Mexico City and compiled by the International Society of Nephrology and kidney health experts worldwide and published in JAMA- highlights the huge gaps in kidney disease care and prevention in both developed and developing countries, with many countries not prioritising kidney health.

21 Apr 2017

Research findings pave way for more efficient, protective influenza vaccines

New findings challenge the traditional policy of replacing old strains in existing human influenza vaccines with recent variants with only minimal changes.

21 Apr 2017

Researchers discover how protein aggregation triggers aging

Not only does our way of life determine how long we live but so too does our genetic material. Of particular importance here is a genetic program that is controlled by the insulin receptor. A team of researchers from the Universities of Cologne and Bonn has now discovered how protein aggregation affects this genetic program and thus triggers aging.

21 Apr 2017

Hockey players with multiple concussions may have other injuries in their brains, research reveals

The relationship between head injuries suffered during contact sport and Alzheimer's disease is now being called into question thanks to research by the Sahlgrenska Academy, which has revealed that hockey players with multiple concussions probably have other injuries in their brains.

21 Apr 2017

Protein C News and Research

Study provides new understanding of molecular mechanisms that impact intellectual disability

Research findings shed light on brain’s ability to make split-second decisions

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Low levels of NPTX2 protein in the brain may lead to learning and memory loss in Alzheimer's disease

Novel mechanism of antidepressant action may benefit patients unresponsive to SSRI treatment

Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers

UTSW researchers develop new nanoparticle vaccine immunotherapy that targets multiple tumor types

Scientists receive $2.8 million federal grant for diabetic cardiomyopathy research

Researchers discover gene that may play role in restoring hearing after noise exposure

Synchronized voltage rhythms in SCN could play role in maintaining the body’s circadian clock

Tiny silica 'cages' could help store and transport vaccines without refrigeration

Researchers discover new cellular mechanism that may cause multiple sclerosis

Testing for molecular markers in urine could reveal early signs of kidney transplant failure

Transgenic fruit flies can shed light on genetic mutations that underlie kidney disease in humans

Researchers show how fish oil component helps in survival of injured retina, brain cells

Global Kidney Health Atlas highlights huge gaps in CKD care and prevention

Research findings pave way for more efficient, protective influenza vaccines

Researchers discover how protein aggregation triggers aging

Hockey players with multiple concussions may have other injuries in their brains, research reveals

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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