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Pergamum reaches LPLV in Phase I/II trial of LL-37 for treatment of hard-to-heal venous leg ulcers

Pergamum AB announced today that the company has reached last-patient-last-visit in a randomized Phase I/II trial of LL-37 for the treatment of hard-to-heal venous leg ulcers. Karolinska Development AB is the majority owner of Pergamum.

23 Apr 2013

Enrollment for Pharmacyclics' Phase III study using ibrutinib in CLL patients completed

Pharmacyclics, Inc. announced today that the enrollment target of 350 patients for its Phase III study using ibrutinib monotherapy versus ofatumumab in patients with relapsed or refractory chronic lymphocytic leukemia / small lymphocytic lymphoma, (RESONATE) was achieved on April 3, 2013.

23 Apr 2013

Alkermes reports topline results from phase 2 study of ALKS 5461 drug for major depressive disorder

Alkermes plc (NASDAQ: ALKS) today announced positive preliminary topline results from a phase 2 study of ALKS 5461, its novel drug compound for major depressive disorder (MDD) in patients who have an inadequate response to standard therapies for clinical depression.

22 Apr 2013

Clinical Research Forum selects sickle cell project among 'Top 10' clinical research achievements of 2012

Pioneering research led by Johns Hopkins scientists on the use of partially matched bone marrow transplants to wipe out sickle cell disease has been selected as one of the Top 10 Clinical Research Achievements of 2012 by the Clinical Research Forum.

22 Apr 2013

Study indentifies unmet medical need for treatment of patients with chronic pain and dysphagia

Collegium Pharmaceutical, Inc., a specialty pharmaceutical company focused on the development of innovative treatments for chronic pain, today announced the completion of a research study, conducted with an independent market research firm, that identified a significant unmet medical need for improved treatments for patients with chronic pain and dysphagia/odynophagia. In clinical practice, dysphagia is most often defined as difficulty in swallowing and odynophagia is defined as pain upon swallowing.

22 Apr 2013

Time dwindling to meet IDSA goal of 10 new antibiotics by 2020

Despite the desperate need for new antibiotics to combat increasingly deadly resistant bacteria, the U.S. Food and Drug Administration (FDA) has approved only one new systemic antibiotic since the Infectious Diseases Society of America (IDSA) launched its 10 x '20 Initiative in 2010 - and that drug was approved two and a half years ago.

22 Apr 2013

Non-invasive brain surgery: an interview with Dr Andres Lozano, University of Toronto

MR-guided focused ultrasound is a new technique that involves focusing 1024 beams of ultrasound through the skull to a focal point in the brain, very much like using the sun and a magnifying glass to burn a hole in a sheet of paper.

22 Apr 2013

Despite public health efforts, sodium intake continues to rise.

Sodium intake around the world is well in excess of physiological needs and public health authorities agree that chronic excess sodium intake can increase blood pressure and the risk of heart attack and stroke. However, despite recommendations to lower sodium consumption over the last decade, actual intake continues to rise.

22 Apr 2013

Young asthmatic patients have lowest levels of health insurance coverage

It is widely accepted that medical insurance helps older adults with chronic health problems to receive better care. But what about young adults between the ages of 18 and 25, a demographic that also tends to have the lowest levels of health insurance coverage?

22 Apr 2013

DecImmune and DSM to develop proprietary antibody therapeutic

DSM Pharmaceutical Products, the custom manufacturing and technology business of Royal DSM (NYSE, Euronext: DSM KON), announced today that it has signed an agreement with venture capital funded DecImmune Therapeutics of Cambridge, Massachusetts, USA.

22 Apr 2013

Sleep related breathing disorders associated with cognitive and behavioral impairment in children

People lobbying for gun control may want to consider another culprit in the post-Newtown search for the answer to our unfathomable questions.

22 Apr 2013

Genetic study defines link between primary sclerosing cholangitis and other autoimmune diseases

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.

22 Apr 2013

Research findings describe specific profile of patients with ACLF

In this prospective study, led by Dr Richard Moreau, INSERM Research Director (Mixed Research Unit 773 "Centre de Recherche biom-dicale Bichat-Beaujon"; INSERM/Universit- Paris Diderot) who is also a practitioner attached to the Hepatology Department of the Beaujon Hospital (AP-HP), researchers studied a cohort of 1343 patients from 12 European countries.

20 Apr 2013

Researchers map use of alternative treatment among multiple sclerosis patients

A major Nordic research project involving researchers from the University of Copenhagen has, for the first time ever, mapped the use of alternative treatment among multiple sclerosis patients - knowledge which is important for patients with chronic disease and the way in which society meets them.

19 Apr 2013

Drug that targets phosphate does not improve CVD measures in patients with mild kidney disease

High phosphate levels in the blood carry increased heart-related risks, but taking a drug that targets phosphate does not improve cardiovascular measures in patients with mild kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

19 Apr 2013

Study: Mediterranean diet associated with lower risk of hyperuricemia in older adults

According to a study published in the Journals of Gerontology Series A: Biological Sciences and Medical Sciences, a baseline adherence to a Mediterranean diet (MeDiet) is associated with a lower risk of hyperuricemia, defined as a serum uric acid (SUA) concentration higher than 7mg/dl in men and higher than 6mg/dl in women.

19 Apr 2013

BGU, FCCC receive NIH grant to study role of microRNAs in maintaining measles virus persistence

American Associates, Ben-Gurion University of the Negev announces that Ben-Gurion University of the Negev and Fox Chase Cancer Center in Philadelphia have received a two-year National Institutes of Health research grant to observe "the role of host encoded microRNAs in the maintenance of the measles virus persistent state."

19 Apr 2013

Chronic News and Research

Pergamum reaches LPLV in Phase I/II trial of LL-37 for treatment of hard-to-heal venous leg ulcers

Enrollment for Pharmacyclics' Phase III study using ibrutinib in CLL patients completed

Alkermes reports topline results from phase 2 study of ALKS 5461 drug for major depressive disorder

Clinical Research Forum selects sickle cell project among 'Top 10' clinical research achievements of 2012

Study indentifies unmet medical need for treatment of patients with chronic pain and dysphagia

Time dwindling to meet IDSA goal of 10 new antibiotics by 2020

Non-invasive brain surgery: an interview with Dr Andres Lozano, University of Toronto

Despite public health efforts, sodium intake continues to rise.

Young asthmatic patients have lowest levels of health insurance coverage

DecImmune and DSM to develop proprietary antibody therapeutic

Sleep related breathing disorders associated with cognitive and behavioral impairment in children

Genetic study defines link between primary sclerosing cholangitis and other autoimmune diseases

Research findings describe specific profile of patients with ACLF

Researchers map use of alternative treatment among multiple sclerosis patients

Drug that targets phosphate does not improve CVD measures in patients with mild kidney disease

Study: Mediterranean diet associated with lower risk of hyperuricemia in older adults

BGU, FCCC receive NIH grant to study role of microRNAs in maintaining measles virus persistence

First Edition: April 19, 2013

PKC supplies Nano-Impedance Biosensor for detecting VEGF-165

New health MOT-style programme likely to uncover more diabetes, kidney or heart patients

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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